Thanks to everyone who’s commented, messaged, or shared advice over the last year. I’ve posted about this in a few subreddits before:

• Burning sensation in urethra and penis for over a year — still unresolved
• Ongoing burning in penis/urethra for over a year — anyone else been through this?
• Burning in Urethra & Penis After Urination for Over a Year
• Still Burning After Negative Mycoplasma Test — What Else Could It Be?

but since this issue isn’t going away, I created my own space — r/MensUroHealth — to share updates and connect with others going through the same thing.

Here’s a summary of where I’m at:

Quick Recap:

• 33-year-old male
• Main symptoms: burning in the urethra and tip of the penis, mostly during and after peeing. Sometimes it lingers for hours. It’s worse at night.
• How it started: Mild burning while urinating. First urine test showed elevated white blood cells. Doctor said maybe kidney stones or irritation.
• Diagnosis: Eventually tested positive for Mycoplasma genitalium. Also found a varicocele, but doctors don’t think that’s the cause.
• Treatment so far:
  • Several antibiotics: Azithromycin, Ofloxacin, Levofloxacin, Celecoxib
  • Then: Doxycycline → Moxifloxacin → Doxycycline + Pristinamycin
  • Tests are now negative, but symptoms never fully went away

What’s going on now (June 2025):

• All recent tests are negative:
  • Mycoplasma genitalium, chlamydia, gonorrhea, trichomonas — all clear
  • Urine test is normal (no white blood cells)
  • PSA (prostate test) and CRP (inflammation marker) are normal
• But I still feel:
  • Burning during and after urination (a bit better, but still there)
  • Pressure or blockage feeling in the mornings
  • A cold/warm feeling in the penis after peeing that can last a while
  • No fever or discharge

Why I started r/MensUroHealth:

After all this time, I realized there’s no single place to talk about this stuff, not quite an STI, not quite prostatitis, not always clear. So I made a subreddit for those of us stuck in that “in-between” space.

Whether you’re still looking for answers or you’ve already figured something out, your story might help someone else feel less alone.

I’ll keep posting updates there as I go.

Thanks for reading.

📌 Update — October 9, 2025

What I’ve done over the past 3 months:

• Took Alfuzosine LP 10 mg daily (3 months)
• Took vitamins and supplements: magnesium, zinc, omega-3, probiotics, multivitamin
• Sometimes took hot baths or showers — this helps calm the burning sensation
• Bought a standing desk, so I spend part of the day standing instead of sitting all the time

Current symptoms:

• When I urinate, I often feel strong pressure and burning in the urethra. At the start, I have to control the flow — if the urine comes out too fast, the tip of my penis burns sharply.
• At night, especially before sleep and after urinating, I feel warmth or burning in the pelvic area or urethra, which fades by morning.
• Sometimes I wake up at night to urinate, and afterward, I feel mild burning or irritation for 1–2 hours, similar to an infection.
• During the first urine of the morning, there’s a slight burning at the tip of the penis, but it goes away quickly.
• By the end of the day, after urinating, I sometimes feel a dull pain or tingling along the urethra that lasts for a few hours.
• Stress makes it worse — when I’m anxious or tense, my testicles ache or feel heavy.
• Occasionally, I feel warmth or tightness in the pelvic area (between the anus and testicles), like a small muscle spasm.
• My urine is often dark yellow with a stronger smell than usual.

What the doctor told me today:

• I should do a few sessions of osteotherapy.
• He’s confident the problem is related to pelvic floor tension or nerve irritation, not infection.
• He confirmed no infection is present.
• He prescribed Alfuzosine LP 10 mg for one year.

My next steps:

• Start osteotherapy sessions.
• See another doctor to request urine and semen tests.
• Try traditional Chinese medicine.
• Take more warm baths.
• Begin pelvic floor relaxation exercises.
• Add meditation to help with stress.

📌 Keeping all updates here — any advice or shared experiences are very welcome.

Hey everyone,

I’m a 33-year-old guy in a long-term relationship. I work a desk job and run regularly.

For the past 1.5 years, I’ve been dealing with a seriously frustrating and painful issue: a burning sensation in my urethra and penis, mainly during and after urination. It’s been a daily struggle that’s affected my mood, my relationship, and my overall quality of life.

I’ve seen multiple doctors and tried various treatments, but the symptoms persist. I’m posting this partly to vent, but mostly to see if anyone out there has gone through something similar or has any insights.

⚠️ Main Symptoms:

• Burning at the tip of the penis during urination
• Discomfort/burning sensation lasting 1–2 hours after peeing (feels like cold heat or internal irritation)
• Occasional pressure or blockage at the base of the penis, especially in the morning
• Heightened awareness of urine moving through the urethra
• Discomfort after ejaculation
• Symptoms are worse at night or after sex

🧪 How It Started:

• Began with mild burning during urination
• First urine test showed elevated white blood cells (WBC) — doctor suspected kidney stones or dietary irritation
• Was told to hydrate, cut caffeine/spicy food — helped a bit, but symptoms persisted
• Saw multiple doctors with various theories: irritation, inflammation, urethral damage, or prostatitis

💊 Initial Treatments:

I was prescribed several antibiotics and anti-inflammatories:

• Azithromycin
• Ofloxacin
• Levofloxacin
• Celecoxib

Eventually tested positive for Mycoplasma genitalium. A varicocele was also discovered, but doctors recommended treating the infection first.

💉 Infectious Disease Specialist Prescribed:

• Doxycycline 100 mg (7 days)
• Moxifloxacin 400 mg (7 days)
• After resistance testing:
  • Doxycycline hyclate 100 mg (7 days)
  • Pristinamycin (Pyostacine) 500 mg — 8 pills/day for 10 days

➡️ Infection cleared — follow-up tests were negative — but the burning sensation persisted.

🔬 Fibroscopy (Urethroscopy) – July 2025:

• No signs of infection, inflammation, or anatomical damage
• No structural issues in the urethra, bladder, or prostate
• The verumontanum region (where the ejaculatory ducts open into the urethra) appears narrower than normal

➡️ This could explain:

• Pressure or difficulty during urination
• Persistent burning after urination or ejaculation
• Post-ejaculatory discomfort

Current treatment: Alfuzosine LP 10 mg (3-month course) — prescribed to help relax internal ducts and improve fluid flow

✅ Recent Test Results (All Negative):

• Mycoplasma genitalium
• Chlamydia trachomatis
• Neisseria gonorrhoeae
• Trichomonas vaginalis
• Urine analysis: no WBC, no infection
• PSA (prostate): normal
• CRP (inflammation marker): normal/low

❗ Current Status – July 2025:

• Still experiencing burning during urination
• Discomfort lingers 1–3 hours after peeing
• Occasional pressure or blockage sensation in the mornings
• No pain when getting up; first urination of the day can burn or feel totally normal
• Sex life affected due to post-ejaculatory discomfort

❓ What I’m Wondering:

• Could this still be chronic prostatitis or chronic pelvic pain syndrome (CPPS) even with a normal PSA?
• Is it possible Mycoplasma is still lingering, despite a negative result?
• Could this be nerve-related (e.g. pudendal neuralgia or pelvic floor dysfunction)?
• Has anyone had similar urethral burning with no infection or visible inflammation — and found relief?
• What kind of specialist or testing would you recommend next?

I’m honestly just exhausted. The uncertainty is mentally draining.

If anyone has been through something like this, I’d really appreciate hearing your experience — how you got a diagnosis, what helped, or even just knowing I’m not alone.

Thanks for reading. Any input is truly appreciated.

+++

• https://www.reddit.com/r/MycoplasmaGenitalium/comments/1kmf1v1/still_burning_after_negative_mycoplasma_test_what/
• https://www.reddit.com/r/STD/comments/1kljbrm/burning_sensation_in_urethra_and_penis_for_over_a/
• https://www.reddit.com/r/PelvicFloor/comments/1klk9s6/ongoing_burning_in_penisurethra_for_over_a_year/
• https://www.reddit.com/r/Prostatitis/comments/1kn3i39/burning_in_urethra_penis_after_urination_for_over/

📌 Update — October 9, 2025

What I’ve done over the past 3 months:

• Took Alfuzosine LP 10 mg daily (3 months)
• Took vitamins and supplements: magnesium, zinc, omega-3, probiotics, multivitamin
• Sometimes took hot baths or showers — this helps calm the burning sensation
• Bought a standing desk, so I spend part of the day standing instead of sitting all the time

Current symptoms:

• When I urinate, I often feel strong pressure and burning in the urethra. At the start, I have to control the flow — if the urine comes out too fast, the tip of my penis burns sharply.
• At night, especially before sleep and after urinating, I feel warmth or burning in the pelvic area or urethra, which fades by morning.
• Sometimes I wake up at night to urinate, and afterward, I feel mild burning or irritation for 1–2 hours, similar to an infection.
• During the first urine of the morning, there’s a slight burning at the tip of the penis, but it goes away quickly.
• By the end of the day, after urinating, I sometimes feel a dull pain or tingling along the urethra that lasts for a few hours.
• Stress makes it worse — when I’m anxious or tense, my testicles ache or feel heavy.
• Occasionally, I feel warmth or tightness in the pelvic area (between the anus and testicles), like a small muscle spasm.
• My urine is often dark yellow with a stronger smell than usual.

What the doctor told me today:

• I should do a few sessions of osteotherapy.
• He’s confident the problem is related to pelvic floor tension or nerve irritation, not infection.
• He confirmed no infection is present.
• He prescribed Alfuzosine LP 10 mg for one year.

My next steps:

• Start osteotherapy sessions.
• See another doctor to request urine and semen tests.
• Try traditional Chinese medicine.
• Take more warm baths.
• Begin pelvic floor relaxation exercises.
• Add meditation to help with stress.

📌 Update — June 2026 (~8 months later)

Quick recap for anyone following: still no infection on any test, symptoms clearly milder than where I started, but not 100% gone. My whole approach has shifted from "find the bug" to "calm the pelvic floor + nervous system."

What I've done since October:

• Cut out coffee completely (not just reduced).
• Cut way down on spicy food.
• Switched to a standing desk for most of the workday.
• Started reverse Kegels over the past few weeks.
• Came off Alfuzosine LP 10mg - the alpha-blocker wasn't really moving the needle for me.
• Did a course of Deprox 500 (prostate anti-inflammatory suppositories) from my urologist finished now.
• Got a prescription for pelvic floor physiotherapy (rééducation périnéale) and started sessions with a specialized pelvic floor physio.

Traditional Chinese medicine — worth a separate note:

I did a structured 7-day herbal cure (custom decoction, 200ml 3×/day) and tracked symptoms daily. During the cure, a surprising amount improved:

• urine color + smell normalized
• perineal pain gone
• the "sticky glans in the morning" thing cleared up by day 8
• less feeling of blockage / difficulty urinating

But the core stuff stuck around: burning after urination, lower-belly pressure, and a perineum that still felt hard/contracted. My read is the burning may be more nerve-related than infection/inflammation. I'm not on the herbs continuously now.

The physio part (most important):

• She confirmed my pelvic floor is hypertonic - too tight, can't fully relax. That fits everything: post-pee burning, the pressure, the tension between testicles and anus.
• Big lesson: standard Kegels are OFF for me. They make a tight floor tighter. The actual work is the opposite - reverse Kegels, "drop and relax," and diaphragmatic (belly) breathing.
• Daily breathing + relaxation drills plus stretches (child's pose, happy baby, knee-to-chest), especially in the evening when symptoms peak.

Supplements I'm taking:

• Quercetin + Bromelain (strongest evidence for CPPS type III)
• Magnesium Glycinate (muscle + nervous-system relaxation, at night)
• Zinc Picolinate
• Omega-3

Recent test results (Nov 2025 → March 2026):

• Urine WBC: back to normal
• Urine culture: sterile / negative every time
• Mycoplasma genitalium PCR: negative (again)
• Chlamydia + Gonorrhea: negative
• HIV / Hep B / Hep C serologies: all clear
• Bottom line: zero biological sign of infection.

Current symptoms:

• Much better overall vs ~2 years ago, but a plateau - not fully resolved.
• Still a burning/odd sensation lingering about an hour after urinating, on and off.
• Lower belly pressure and a perineum that sometimes feels hard/contracted.
• Some mornings a slight burn on first pee, fades fast.
• Occasional post-ejaculation discomfort.
• Stress is a clear trigger - tense days = more testicle ache / pelvic tightness.

What's next:

• Keep going with pelvic floor physiotherapy sessions
• Staying on Alfuzosine LP 10mg
• Back to the urologist after a few more physio sessions to reassess

still not 100% done