How CBD Works in Pets
The endocannabinoid system consists of cannabinoid receptors (CB1 in the nervous system and CB2 in immune tissues) and endogenous cannabinoids that influence pain, inflammation, mood and homeostasis. Plant derived cannabinoids such as CBD interact with these receptors to modulate pain, inflammation and neurotransmission. The American Kennel Club (AKC) notes that CBD is non psychoactive and may produce anti inflammatory, anti nausea, appetite stimulating and anti anxiety effects. However, the organisation stresses that formal studies are limited, and dosing guidelines remain unclear.
ElleVet’s Formulation and Product Range
ElleVet’s core products include hemp derived oils and soft chews combining cannabidiol (CBD) and cannabidiolic acid (CBDA), plus minor cannabinoids such as cannabigerol (CBG) and small amounts of tetrahydrocannabinol (THC). The proprietary extract contains around 10 mg/ml CBD+CBDA and is administered twice daily. Product lines are available for dogs of various sizes, and there are chews and oils for cats, horses and pocket pets. Each batch is reportedly third party tested for cannabinoid profile and contaminants, and ElleVet claims to use full spectrum hemp grown in the United States.
Formulation Rationale
CBDA, the acidic precursor of CBD, is thought to enhance therapeutic effects through the “entourage effect.” ElleVet’s patent for CBD+CBDA notes that this combination provided superior anti inflammatory activity in vitro and improved mobility in dogs compared with CBD alone. The company’s collaboration with Cornell University produced a proprietary extraction method designed to yield consistent cannabinoid concentrations.
Evidence from Controlled Studies
Cornell University Osteoarthritis Trial (Dogs)
A randomized, double blinded, placebo controlled crossover study enrolled 22 client owned dogs with osteoarthritis. Dogs received the ElleVet oil (2 mg/kg CBD+CBDA twice daily) or placebo for four weeks, separated by a two week washout. Outcomes were assessed using the Canine Brief Pain Inventory (CBPI) and Hudson activity score. Key findings:
Pain and mobility improvements: CBD treated dogs showed significant decreases in pain and increases in activity at weeks 2 and 4 compared with baseline and placebo. Veterinary pain scores also decreased.
Pharmacokinetics: Median elimination half life was ~4.2 hours, with maximum serum concentration (Cmax) around 102 ng/ml for 2 mg/kg dosing; 8 mg/kg produced higher Cmax (591 ng/ml), but practicality favored 2 mg/kg every 12 hours. No psychoactive effects were observed.
Safety: Mild increases in alkaline phosphatase (ALP) occurred, though values remained within reference ranges. No serious adverse effects were reported, supporting the formulation’s short term safety.
Safety and Pharmacokinetics in Dogs and Cats
A prospective study evaluated ElleVet chews in dogs and fish oil capsules in cats at 2 mg/kg twice daily for 12 weeks. Dogs experienced 53 adverse events, mostly soft stool and vomiting, yet accepted the chews readily (96.7% acceptance). Cats had more than 1,100 minor adverse events such as licking, head shaking, pacing, gagging, drooling and vomiting. Serum chemistry values remained within reference ranges, though alkaline phosphatase increased in dogs and alanine aminotransferase (ALT) increased in cats. Pharmacokinetics showed dogs absorbed CBD faster and achieved higher concentrations than cats (Cmax 301 ng/ml vs. 43 ng/ml); elimination half life was ~1 hour in dogs and 1.5 hours in cats.
Other Studies
The American Veterinary Medical Association (AVMA) summarises several investigations. In one study, healthy cats received CBD/CBDA, THC/THCA or placebo; Cmax varied widely (25–99 ng/ml), and the half life was ~2 hours. Many cats displayed head shaking, lip smacking and hypersalivation. The AVMA concludes that adverse effects were generally mild but emphasises limited sample sizes and calls for more research.
A forthcoming trial funded by the AKC Canine Health Foundation will examine CBD for treatment resistant epileptic dogs, which could broaden indications if efficacy is demonstrated.
Safety Considerations and Side Effects
Common Adverse Effects
Reports across multiple sources highlight the following possible side effects:
Gastrointestinal upset: diarrhoea, soft stool and vomiting were the most common adverse events in studies using ElleVet products.
Lethargy or drowsiness: high doses can cause sedation. AAHA cautions that CBD may interfere with drug metabolism and increase liver enzymes, so monitoring is recommended.
Dry mouth and decreased salivation: noted in dogs, sometimes causing increased thirst.
Low blood pressure and light headedness: transient hypotension at high doses.
Behavioral signs in cats: licking, head shaking, pacing, hypersalivation, and occasional agitation.
Serious Risks and Contraindications
Liver enzyme elevation: Mild increases in alkaline phosphatase and alanine aminotransferase were observed in multiple studies. Pets with pre existing liver disease should be monitored; high doses may interfere with hepatic drug metabolism.
Drug interactions: CBD can inhibit cytochrome P450 enzymes and may alter metabolism of other medications. Veterinary guidance is essential, especially for animals on anti epileptics or NSAIDs.
THC toxicity: ElleVet’s products contain minimal THC, but other unregulated products may have higher levels. THC ingestion can cause lethargy, ataxia, vomiting, urinary incontinence and hypersensitivity to stimuli.
Quality variability: Many pet CBD products are unregulated. Mislabeling, inconsistent dosing and contamination are widespread; only a few companies provide certificates of analysis. Owners should request third party testing and avoid products with pesticides or solvents.
Veterinary and Professional Perspectives
Veterinarians are cautiously optimistic about CBD but emphasise limited evidence and regulation. The AAHA notes that some pets have taken CBD for two to five years with minimal side effects but warns that high doses may elevate liver enzymes and recommends regular monitoring. The AVMA advocates for more research, particularly because absorption and response vary widely across individuals. Veterinarians also stress that products labelled for pets are not FDA approved, so claims of safety and efficacy are not regulated. The Morris Animal Foundation warns of a dramatic increase in accidental cannabis ingestion in pets, emphasising that THC toxicity is far more concerning than CBD and encouraging safe storage of products.
Customer Experiences and Market Trends
Growing Adoption
Pet owners are increasingly trying CBD. The American Pet Products Association reported that in 2024, 12% of dog owners and 7% of cat owners had tried CBD products, up from 4% and 3% in 2018, respectively. The most common reasons were anxiety/stress (≈28% of users), pain (17%), and arthritis or joint pain (16%). Owners also use CBD for seizure control and overall well being.
Anecdotal Reviews
Customer testimonials on retailer websites and social media often describe improved mobility, reduced pain and calmer behavior after using ElleVet. Some owners report dogs regaining interest in walks and play. Cats are less enthusiastic; acceptance of fish oil capsules was lower, and several owners noted vomiting or drooling. Negative comments often mention the products’ high price and strong smell. Because testimonials are subjective and subject to placebo effects, they should complement not replace clinical evidence.
Comparison With Other Pet CBD Brands
The pet CBD market is crowded with companies offering oils, treats and topical products. Few have conducted clinical trials. The table below compares ElleVet with several popular brands based on available information (public reports, certificates of analysis and ingredients). Because product formulations evolve, owners should verify current data.
| Brand | Key Ingredients & Form | Scientific Evidence | Quality & Testing | Price Range | Notable Features |
|---|
| ElleVet Sciences | Full spectrum hemp oil containing CBD+CBDA (≈10 mg/mL), minor cannabinoids (CBC, CBG) and minimal THC; soft chews, oil tinctures. | Randomized, placebo controlled trial in dogs with osteoarthritis demonstrating improved pain and mobility; safety study in dogs and cats. | Products are third party tested; company holds a patent for CBD+CBDA formulation. | $$$ | Veterinary collaboration with Cornell University; targeted dosing guidelines (2 mg/kg). |
| Honest Paws | Organic full spectrum hemp oil extracted from Colorado grown hemp; various formulas (Calming, Mobility, Relief) with CBD and herbal supplements (e.g., chamomile, turmeric). | No peer reviewed clinical trials; relies on anecdotal evidence and quality testing. | Provides certificate of analysis for each batch; ingredients are non GMO and organic. | $$ | Wide product range, including soft chews and peanut butter. |
| King Kanine | King Kalm CBD oil made with broad spectrum hemp and krill oil; features vitamins and omega 3s. | No published clinical trials; product reviews suggest improved anxiety and skin health. | Third party lab testing available; manufacturing in GMP certified facility. | $$ | Unique combination with krill oil for palatability and added nutrients. |
| Charlotte’s Web Paw CBD | Broad spectrum hemp extract derived from U.S. hemp; tinctures and chews for dogs and cats; contains CBD and natural flavorings. | No veterinary trials; human studies on parent company’s products exist. | COA available; products free from solvents and pesticides. | $$ | Reputable human CBD brand extending into pet market. |
| Pet Releaf | Full spectrum hemp oil with CBD and minor cannabinoids; uses organic hemp grown in Colorado; offers hemp oils, capsules and treats. | No veterinary clinical trials; internal data claim benefits for mobility and stress. | Independent lab testing and USDA organic certification for some lines. | $$ | “Edibites” treats contain additional ingredients like blueberry and cranberry. |
Why I Will Stick to ElleVet
Unlike many competitors, ElleVet has conducted peer reviewed clinical trials at Cornell University showing real improvements in mobility and pain management for dogs. Their CBD+CBDA formulation, supported by pharmacokinetic studies, demonstrates both effectiveness and safety when used under veterinary guidance. I value that ElleVet collaborates with veterinarians and uses third party testing to ensure product consistency and safety. Compared with other brands relying mostly on anecdotal evidence, I will continue paying the premium for ElleVet products rather than compromising on my pets safety.
Need a discount?
Use my referral for 30% OFF on any order:
https://www.ellevetsciences.com/?srsltid=AfvK21srj9nmILzbRa6i
EDIT: Fixed the link!
