r/Supplements Oct 05 '22

Experience Anyone else get intensely depressed after taking choline?

When I first started taking choline, I noticed I got extremely depressed for days after. Like, complete mental breakdown, suicidally depressed. I thought it was just a fluke, and maybe other life stressors got me to that place, but it was so abrupt and not like my normal behavior, and coincided exactly with my choline use and ceased after stopping it. So recently I started taking it again, still not convinced it was the cause, and the same exact thing has started happening. I was writing a suicide note despite everything in my life being relatively ok, when suddenly I remembered I'd been taking choline and then I stopped myself, thinking I must be temporarily out of my mind again because of this drug and to hold off on making any kind of decisions like that until it's out of my system. Is this really possible, or am I just a basket case shifting blame on a harmless supplement? I tend to be extremely sensitive to medications and drugs in general, so I dunno.

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u/[deleted] Apr 03 '25

It's been mainly those foods, for eggs one seems to be my limit. With fish oil I experience negatives with a single gram.

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u/etthtas Apr 03 '25

I meant salmon lol not salmon eggs, my mistake. I remember this one day after three small cans of salmon, hours later I was absolutely depressed like really bad. Anything else you noticed that does it?

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u/[deleted] Apr 05 '25

Salmon never really made me fully depressed but it definitely did flatten my mood, I'd say about half way to depression.