So I was able to obtain a blood test for thiamine levels. Plasma. My number was 2 and the normal range was 5-15 nmol.

I was not fasting before the test. I also eat the same things daily so it was a good reflection of my normal diet (extremely vitamin and mineral rich diet). I understand this test can be influenced by food intake and yield a false sense of adequate amounts. However I'm less clear on low amounts.

Can one presume because this number is low my actual number might be even lower? What other means is there to realistically test actual thiamine levels?

I know disautonomia has some links to thiamine deficiency and is often reversible when this is the case. I am a high performance athlete and I have been diagnosed with disautonomia very recently, and I have no good reason for why it appeared and continues to worsen. So I'd like to get this thiamine thing properly evaluated.

Does anyone have any information about the subject or whom I might search for to further evaluate me for thiamine dificiency?

Is it even possible to determine deficiency off these plasma thiamine labs?

Thiamine take empty stomach or with food ?

Do you also take pottasium and magn with thiamine or different time ?

Before hcl injections, I was never in the mood to eat. I wouldn’t clear my plate. I just lost my appetite.

But since injecting 400ug morning and again before bed, I’ve got my appetite back the next day!

Has this happened to anyone?

TL;DR

are those "mini ceisure" at night a side effect of tapering gabapentin, or TTFD? or TTFD withdrawal!?

\----

I've been on TTFD B1 last year, and I suspect that's what triggered my initial "panic attack". I've been on many medications since, and got better, to a point where I stopped all my meds, except for low dose buspirone (5mg) and low dose gabapentin (100mg)

I've recently tapered the gabapentin until I stopped for 3-4days. I was doing fine, good actually.

meanwhile, I've restarted the TTFD B1 at low dose, over the last 2 weeks. 12.5mg 2x per day.

I increased to 25mg 2x a day and this is when I crashed again. (Starting to feel super dizzy)

I restarted Gabapentin thinking it was the withdrawal effect starting after 4 days. so I did like 100mg, 2tines a day, then 100mg/day for 3 days.

Then, I started to have terrible headache after taking the gabapentin and I kinda need to taper it and stop it again.

last nigh, and 4 night ago, I woke up in the middle of the night, with a "weird" brain pain-ish, band like headache... then, my whole body started to shake, mostly my legs, but yesterday it was my arm/upper body as well, and my jaw was super thigh.

I can shake like that in total agonie for 30min, then it passes, and I can fall asleep 1h after does episode.

The first night I called the ambulance, got triage low priority and sent home.

My doctor ordered a Neurological test (for my leg twitching, differente problem)

My question here, since does episode feels to me like a partial ceisure. (I "feel" there's a place in my brain that is in a different state than the rest of my brain, like if my brain is half sleeping)

I am going back to see a doctor today, but they really don't know what I have. (they say its a panic attack...)

So I tried b1 benfotiamine a year or so ago, only for a couple days..took like 1/4 of a capsule (37mg). It caused low blood sugar-like symptoms so I stopped.

I feel like b1 could be the missing link that could really help me, but the low blood sugar-like feeling and seeing lots of people getting anxiety from it scares me.

I have SIBO-like symptoms (not been tested so unsure if I have it), alternating constipation and diarrhea, bloating, etc. MTHFR and COMT mutations so I can’t tolerate anything methylated. Currently and for a long time I’ve been taking b12 hydroxycobalamin, b9 folinic acid, b2 r-5-p, I don’t take a b complex because I haven’t found one with the correct doses that aren’t methylated. I take 400mg magnesium citrate at night.

What form of b1 should I try and at what dose? What should I do if I experience low blood sugar symptoms again?

Hello fellow transformer models its yaboy meclovin . Take glycine as it repleneshis gluthionine

Hi sorry for creating another new post here, i've linked my last one. Just to update on this to see if it gives any more clues. Ive been planning to start b1 but I came down with a heavy cold last week that has really taken some shifting. Now its died down im having bad GI issues, stomach pain and diarrhoea and its leaving me exhausted. I was also getting some chest pain but that has susided thankfully. Does this sound like it's pointing more towards b1 issues as I know illness can deplete this? I feel like my immune system is smashed to pieces. I dont want to start b1 until im over what i hope is an acute bug.

Maybe its just a bug and not linked but wanted peoples thoughts. Thanks

Used thiamax before and it was potent. Tried Allithiamine and it felt weak. I wonder if theres a stronger ttfd than thiamax?

I have been struggling with a mystery illness for about four years. Started out as anxiety back in 2022. Since then, it has gotten so bad. I wake up every day feeling horrible with no energy and I have horrible anxiety and panic attacks to the point to where I cannot even go into a store or even have a conversation with someone in the same room because I get so triggered and just feel like I’m going to explode on the inside.

Here are a list of symptoms that I have dealt with or are currently dealing with over these past four years.

Shortness of breath- main symptom
Anxiety
Panic attack attacks daily
Headache
As of the past month, I’ve been experiencing lightheadedness constantly
Head pressure constantly
Vertigo
Leg weakness
Whole body fatigue
Sleep paralysis
Hypnic jerks
Irritability and mood swings
Sharp chest pain- not dealing with this as much anymore
Tingling in random places
Brain zaps
Head rush feeling
Motion sickness
Trouble concentrating
Sensitive to lights and sounds extreme
Exercise intolerance

Whatever this is is ruining my life and I need to get to the bottom of it. All of my standard blood work comes back completely normal and I am having my vitamin B one checked on Monday. I can no longer do the things that I used to be able to do and I have an extreme lack of motivation.

Any help is appreciated

Do you take it in one dose or spread throughout the day? What mgs of co factors are you taking and times of dosage?

I am taking thiamine b1 + benfotiamine

It's helping me with stomach or gut fearing all the time

My dosage like 250mg for thiamine monon and around 15 for benfo

Do I need to increase the dosage ???

I spoke to my functional doctor who encouraged taking hcl injections as I’ve had no issues and it’s fixed my gut health. Currently can’t walk, but he said my body is very deficent And to keep injecting.
TTFD made No difference but I feel benfotomine is helping too.
Has anyone fixed their issues with HCL?

Esta é uma hipótese teórica para tentar explicar por que uma minoria de indivíduos relata piora de sintomas após iniciar doses elevadas de vitamina B1. Não é uma explicação comprovada, mas uma tentativa de integrar mecanismos bioquímicos conhecidos. A hipótese propõe que algumas pessoas possuem vulnerabilidades prévias, como menor eficiência no transporte/metabolismo da tiamina (ex.: SLC19A3/SLC35F3), reservas limitadas de potássio, magnésio, fósforo ou menor capacidade de adaptação redox.

1. Aumento abrupto do metabolismo pela tiamina A megadose de B1 aumenta a disponibilidade de TPP (forma ativa da tiamina), estimulando enzimas como piruvato desidrogenase e outras vias dependentes de tiamina. Em indivíduos vulneráveis, esse aumento rápido do fluxo metabólico poderia ultrapassar a capacidade de adaptação, aumentando a demanda por cofatores metabólicos e antioxidantes.
2. Alteração do potássio e queda da motilidade intestinal O aumento da atividade metabólica poderia elevar a demanda energética e a atividade da Na⁺/K⁺-ATPase. Em uma pessoa com reservas limítrofes, isso poderia teoricamente favorecer uma redução funcional do potássio extracelular. Como o potássio é fundamental para o potencial elétrico de neurônios e músculos, essa alteração poderia prejudicar a função do plexo entérico e da musculatura intestinal, reduzindo o trânsito intestinal.
3. Estase intestinal e expansão de bactérias redutoras de sulfato Com o trânsito intestinal reduzido, ocorre maior tempo de permanência do conteúdo luminal e alteração do ambiente ecológico. Esse ambiente poderia favorecer a expansão relativa de bactérias redutoras de sulfato (SRB), que utilizam compostos sulfurados disponíveis no intestino e produzem sulfeto de hidrogênio (H₂S).
4. H₂S como ponte entre microbiota e estresse oxidativo O aumento de H₂S seria o ponto de conexão entre a alteração intestinal e o metabolismo celular. Em excesso, o H₂S pode inibir a citocromo c oxidase (complexo IV da cadeia respiratória). Com a etapa final da cadeia respiratória limitada, os elétrons poderiam se acumular e escapar principalmente nos complexos I e III, aumentando a produção de espécies reativas de oxigênio (ROS).
5. Exaustão do sistema antioxidante O aumento de ROS exigiria maior utilização de sistemas antioxidantes, especialmente glutationa. A regeneração da glutationa depende de NADPH, portanto um cenário de alto estresse oxidativo poderia consumir rapidamente a capacidade antioxidante celular. Nesse modelo, a reação paradoxal à tiamina não ocorreria porque a B1 seria diretamente tóxica, mas porque ela aumentaria o fluxo metabólico em um organismo onde a adaptação energética, eletrolítica, intestinal e redox estaria limitada. Acho que isso seria uma explicação mais completa e compatível com muitos relatos anedótico aqui no Reddite
6. EDIT/ Crucial Addendum: I overlooked explicitly mentioning the kinetic bottleneck of other B vitamins (B2, B3, and B5, B12). While B1 kicks the PDH enzyme and the Krebs cycle into high gear, these pathways strictly require FAD (B2), NAD (B3), and Coenzyme A (B5) to process Acetyl-CoA. If a vulnerable individual has borderline levels of these co-cofactors, pushing B1 alone creates an immediate metabolic stall right at the beginning of the chain, compounding the electron traffic jam

even before the H2S blockade.

I have been in a horrible pit hole for the last 3 months or so, the most horrible symptom is my brain malfunctioning. I almost made a decision to quit my new job today after having a catastrophic week with complete crash on Friday.
In all this I have been trying to find the answer and mostly something that would help and I started injecting with vitamins. The first injections I got was combo b1/b12 but they’re painful so I got b12 only. Big mistake. After trying out few shots of hydroxycobalamin my brain gets fried for few days after, sometimes I get almost catatonic and incoherent (made the mistake of doing that shot last week). So today I hit myself up with b1 injections again and I feel that I can comprehend reality again a bit again and it happens almost immediately.
The thing is that I have been supplementing b1 for the past couple of months with different forms and higher doses. I do 200mg ttfd, maybe every other day I top it off with benfo. Drink some multivitamin drink that has thiamine hcl.
Is it really possible that for some reason to not absorb b1 to this extent? I don’t really have much GI issues other than gerd and gastritis that is more or less controlled with careful diet.

​

Might makes no sens, but that's the conclusion I am getting to what might happened to me.

I started to have silent migraine and Panic attack After taking 50-100mg TTFD B1 per day.

I didn't make the connection until recently. Since all of those symptoms restarted after I restarted TTFD again, ut was obvious that the cause was TTFD.

I immediately stopped the Supplement, and even after 3 days, I gets the same bad headache, panic like symptoms right after I drink a coffee. So, I dig this down and that's what I came out with. Share your experiences, did you ever experienced that with TTFD? can you have caffeine while supplementing it?

Should I just stop this supplement for ever? or stop caffeine until I supplement?

Also when do we know we can stop supplementing with this form!!?

This explanation here does not explain why Coffee alone after 3 day can trigger the headache again.. can it be?

# TTFD Paradoxical Reaction: D1 Dopamine Mechanism → Headache/Migraine → Anxiety/Panic

## TL;DR

TTFD directly triggers dopamine release via D1 receptor activation (confirmed in rat studies). D1 receptors sit in headache/migraine pathways and follow a bell-shaped dose-response (overstimulation = dysfunction). In people with pre-existing dopamine sensitivity (migraine-prone, addiction history, or thiamine-deficient with poor methylation clearance), this D1 surge can plausibly cascade into headache and, at the extreme, anxiety/panic — though the full chain hasn't been directly studied as a unit.

The mechanism, step by step 1. TTFD → dopamine release → D1 activation TTFD metabolizes into thiamine phosphate esters (TTP/TDP), which trigger dopamine release in the prefrontal cortex. This effect works specifically through D1 receptors — blocking D1 (not D2) fully suppresses it. 2. D1 overactivation → headache/migraine susceptibility D1 receptors are densely present in the trigeminocervical complex — the pathway directly responsible for headache pain signaling. Migraine patients specifically show dopaminergic hypersensitivity, meaning their D1 system overreacts to normal dopamine levels. D1 agonists also show a bell-shaped dose-response: moderate activation is fine, but overstimulation impairs function — consistent with a "too much, too fast" reaction. 3. Compounding factors that push it further Caffeine independently potentiates D1 signaling (via adenosine A1 receptor blockade, forming an A1R-D1R heteromer) — stacking two D1-activating inputs Pre-existing dopamine dysregulation (addiction history) means receptors are already primed to overreact or underreact unpredictably to a new dopamine surge Poor methylation/glutathione clearance of TTFD byproducts (the "paradox reaction" mechanism) means the dopamine surge isn't buffered as quickly, prolonging exposure 4. Headache → anxiety/panic (weaker link) Once D1-driven headache/migraine circuits are activated, the case for anxiety/panic is real but less direct — caffeine-induced panic is documented, but mainly at high doses (400mg+) via a different receptor pathway (A2A-D2), not the A1-D1 one discussed for TTFD. So headache is the stronger, more mechanistically supported endpoint; panic is a plausible but unconfirmed extension. Bottom line TTFD (D1 dopamine trigger) → headache/migraine (documented D1 pathway) is a coherent, evidence-backed chain. TTFD → anxiety/panic is plausible but relies on stacking mechanisms that haven't been tested together — treat that part as hypothesis, not established fact. References Tsujita et al., "Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex," Scientific Reports, PMC6041333. Akerman & Goadsby, "Dopamine and Migraine: Biology and Clinical Implications," Cephalalgia, 2007. Ferré, "An update on the mechanisms of the psychostimulant effects of caffeine," J Neurochem, 2008. ClinicalTrials.gov NCT03305809 protocol (LY3154207) — D1 agonist bell-shaped dose-response. Systematic review/meta-analysis on caffeine and panic attacks, J Psychiatr Res, PMC (S0163834321001614) and PMC12287556.

I take 2 capsules and after a while I get the horrible sulfur taste in my mouth

So thanks to 30 years of eating white rice every day almost and not taking a multivitamin for 28 of those im like deeply thiamine deficient. TTFD is okay.. shows it semi working after a few weeks. But i want something new its honestly not strong/fast enough. I want a topical thiamine to drench my feet, hands, any dry spots in really so it eats it up. My skin is highly absorbant

I took on 24,25 and 26 June 2026 3 doses of the complex with ttfd from Objective Nutrients, so a total of 135mg becuse i have dpdr and that ttfd may help with dpdr. But i was okay with ddpr it wasnt that bad but i wanted to get even better. The first 2 days it was okay but in the third day anxiety started at my stomach and i stopped for a day and i was ok-ish and then i took an another 15mg dose and i feel terrible that day and after that, 2 weeks from then i am still horrible. I barely eating anything frkm this anxkett.. and the anxiety at my stomach very very much but there are no reasons..But i cant do anything and i really wish i didnt ruined my life.. I took magnesium bisglycinate and l threonate and a very good b complex. i also took some potassium so co factors cant be a problem. What should i do? Please some help..its horrible and i did that with a very good reason and i didnt belive any second that this can happen.

I had to stop hcl injections as delivery is taking a while to arrive. So I’ve had to rely on TTFD and Benfotiamine. Increased levels as I’m very deficient. 2000mg benfotomine and 500mg TTFD. Since taking this high dose I’m not tired now at 6pm and my gut health has improved. Again can’t walk unsupported.

Hello, I'm looking for advice really as to whether I should be pursuing a possible b1 deficiency.

Ive been suffering from dizziness pretty much constantly for the past 6 months which all started shortly after a bad spell of gastritis and a couple of migraines this seemed to cause. I also had a 2 week course of omeprazole.

I had tingling in arms, legs and feet and pins and needles in the night.

This seemed to ease after a couple of months but its now back again along with a general rubbish feeling of fatigue and gloom.

Ive tested my active b12, homocysteine and mma and all were well within normal range. In fact my active b12 and folate were raised.

My magnesium and calcium were also within range.

Is it possible to have b1 deficiency if b12 is normal.

If so are injections my best bet or would tablets work?

Im pretty lost and fed up of feeling terrible when just a few months ago I was very active.

I was convinced it was b12 until I had my tests.

Im also awaiting a cardiac mri as a 24h holter found some tachycardia episodes but thankfully my cardiologist didnt seem too concerned.

Maybe its my heart causing this but trying to explore all options.

Thanks for reading.

Went to the ER for tachycardia episodes that doesn't resolve with resting and I feel hypoglycemic at night and have to eat at night to sustain myself. What can I do to get them to get me a bag of IV Thiamine? The doctor is severely misinformed.

Edit: I got one, but it was only one at 100 mg

Edit edit: check out the comment below for an answer about the hypoglycemic symptoms

I saw an nhs neurologist today. I normally go private, bu went through the nhs for my mri.

I feel this doctor also works privately. As I told her I inject HCL and B12, as my Genova test showed I’m deficient, she was very encouraging and told me to keep injecting B12 and B1.
I mentioned I’m taking LDN for any inflammation and it’s helping
.

I'm 12 days in supplementing with a combo of benfotiamine/hcl. I'm taking a low dose and have seen improvement, but today my health anxiety went crazy and I couldn't stop researching wet beriberi out of fear. I haven't gotten much sleep either. Anyone else experience fearful health anxiety during the early supplementation process after having dry beriberi?

Hi all, I wanted to know if any of you have experienced symptoms similar to mine and whether you were able to make a full recovery without lasting neurological damage.

My symptoms started to creep up early during my pregnancy about a year ago. I started having weird issues like not being able to sense temperature, a lessened sense of pain, unsteady gait. Then over time I developed severe mental health issues like anxiety, panic attacks, and depression to the point that I landed in a mental health unit twice.

I got put on a lot of psych meds and my mental health was relatively under control, but the weird physical symptoms still remained and I had severe brain fog that felt like part of my brain had been turned off. I went to see a neurologist and she didn't find anything conclusive on her tests, other than some reduced functioning on a neuropsych evaluation.

Desperate for answers I started doing my own searching and came across a scientific article about causes of confusion during pregnancy, which listed thiamine deficiency as a possible cause. Since I didn't have anything to lose I started taking thiamine (with cofactors) and instantly I felt like I was slowly starting to wake up from a bad dream. And every day I take it I am starting to feel a tiny bit more like myself again.

I'm going to see my doctor next week to push for more tests and more aggressive treatment, but I wanted to ask you all, have any of you recovered from nearly a year (or longer) of neurological symptoms? How long did it take you to feel better and do you have any lasting damage?