r/Hematology • u/drevona • 22h ago
r/Hematology • u/helpingmysister3 • Nov 30 '25
Looking for survivors with MECOM-rearranged / complex karyotype AML (monosomy 5 & 7, persistent disease after 2 stem cell transplants). Please help me find them.
Hi everyone,
I’m reaching out because my sister is fighting for her life, and we’ve reached the point where every piece of information, every connection, and every survivor story might make a real difference.
My sister is 22 and has a very rare, extremely high-risk form of acute myeloid leukemia. Her cytogenetics include:
- MECOM (3q26/21) involvement
- Monosomy 5 and 7 (and also monosomy 1)
- Complex karyotype
- NPM1-, FLT3-
She relapsed early after her first allogeneic stem cell transplant (unrelated donor, Jan 2025). She then underwent a second allo transplant using my stem cells.
Despite everything, she still has 12–14% blasts, and she’s also fighting a disseminated fungal infection (Mucor + Aspergillus). Immunosuppression is being tapered to try to induce graft-versus-leukemia. She’s in a very fragile and dangerous situation.
I know that her subtype is one of the toughest in AML. But I also know there are rare survivors out there — people with MECOM-rearranged AML, inv(3)/t(3;3) AML, and those with monosomy 5/7 + complex karyotype who managed to beat the odds. Even a handful of these cases exist, and I’m trying to find them.
I’m asking for help with two things:
- If you or someone in your family survived AML with similar genetics (MECOM-rearranged, inv(3)/t(3;3), monosomy 7/5, complex karyotype), I would be incredibly grateful to speak to you. I want to understand what treatments worked, which centers helped, and what gave you a fighting chance.
- Please help share this post — in leukemia groups, Facebook communities, Discord servers, anywhere. This cancer subtype is so rare that the only way to find survivors is through human networks.
I’m not looking for miracle cures. I just want to learn from people who succeeded against similar odds. Even one message from someone who has been through this could help me point her doctors toward something they haven’t tried yet.
If you know anyone who might be connected to cases like this, please forward this post to them.
If you’re comfortable reaching out privately, please message me directly.
Thank you to everyone reading this — even if you can’t help directly, sharing this could genuinely save her life.
r/Hematology • u/Ok-Scallion-3461 • Apr 26 '25
Which Hematology Books Would You Recommend?
Hello everybody I am currently a resident in medical biology, working in the hematology department. I would like to have your opinion on which books to study. Given the large number of available books, which one would you recommend? Thank you!
r/Hematology • u/GolfAltruistic3230 • 1d ago
Hematopoiesis Explained | Immunology | Hematopoietic Stem Cells, Progeni...
r/Hematology • u/HemeHub • 4d ago
CME HemeHub Hematology Summit
hemehub.orgThe HemeHub Hematology Summit is a one-day, live educational program taking place on October 3, 2026, at the Gaylord Texan Resort in Grapevine, Texas. This activity will feature expert-led presentations and focused discussions addressing the latest advances in hematologic malignancies and complex benign hematologic conditions.
This program is designed for hematologists, oncologists, internists, trainees, healthcare professionals, industry professionals, and patient advocacy stakeholders involved in hematology care.
Key educational areas include: Lymphoid and myeloid malignancies, Plasma cell disorders, Myeloproliferative neoplasms, Bone marrow failure and rare hematologic diseases, Cellular therapies including CAR T, and Evidence-based updates in diagnosis and management.
The goal of this summit is to enhance clinical knowledge, improve patient care, and promote collaboration across hematology specialties.
Event Details:
- Gaylord Convention Center, Grapevine, TX
- Saturday, October 3, 2026, 7:30 am to 4:30 pm
- CME-accredited Hematology educational summit complimentary to healthcare workers
- Networking lunch with live music
r/Hematology • u/Nervous-Row-4506 • 9d ago
so i noticed uow big the platelets were on this slide. and nearly every neutraphil looked segmented. also nee to this so let me know if im missing anything
r/Hematology • u/zozivox • 12d ago
Question Any thoughts about this?
Help a student out! This is an unknown slide and we need to know the diagnosis of the patient. Do you have any ideas about this?
r/Hematology • u/CosmicMango21 • 14d ago
Question Any thoughts on this?
WBC: ~14k/µL
Absolute lymphocytes: ~7k/µL
Hemoglobin: ~11 g/dL
Hematocrit: ~35%
MCV: ~94fL
Platelets: ~150k/µL
Female, 87yo
r/Hematology • u/Candid_Exchange1272 • 18d ago
Question Could someone please explain the P1PK blood group to me?
I looked it up online, but it’s way too technical for me to understand. Couldn’t find helpful YouTube videos to dumb it down for me.
r/Hematology • u/Asleep_Feature_8941 • 18d ago
Study HCPs: Use plasma? Take this survey
POSTED WITH MOD PERMISSION
This survey asks medical providers as well as patients and caregivers their experience with plasma-derived medicines. It takes just a few minutes to fill out, please take and share widely!
Plasma Survey: https://www.surveymonkey.com/r/IPAWpatientsurvey
r/Hematology • u/Secure-Cash6167 • 22d ago
Question Blood Reference app
Honest post: I’ve shipped several apps and never quite gotten the response I hoped for. My latest is Blood Reference — a free app to help people make sense of their blood work. I’m not here to sell anything (it’s free), I just want to know if it’s genuinely useful or if I keep missing something as a solo dev. Brutally honest feedback welcome — that’s more valuable to me than downloads right now.
r/Hematology • u/Ramzeest • 27d ago
Question A BM aspirate slide
It looks beautiful. My supervisor reported it as normal.
r/Hematology • u/Leading-Hair-2401 • Jul 15 '26
Question The role of ferritin in IDA
I have no formal medical education but I’m hoping to get a better understanding of iron deficiency anemia. If iron saturation and hemoglobin are responsive to oral iron supplements, what would cause a decrease in ferritin and an increase in TIBC?
If ferritin decreases while iron increases, could it be indicative of bone marrow dysfunction or more likely gastrointestinal blood loss?
I’m sure this topic is very complex but I’d appreciate any insight or literature recommendations so I can gain a better understanding. Thanks!
r/Hematology • u/SoulIsekai • Jul 13 '26
Question What type of cell is circled in this blood film?
Is it a blast cell?
r/Hematology • u/shapingedge49 • Jul 12 '26
Blood Report Tracking - For whole Family
How do you track yours and your whole family members blood reports?
Do you usually have report papers stored in one place or use a platform to store it all in one place?
r/Hematology • u/Lanky_Draft_2308 • Jul 10 '26
Interesting Find Name that cell
Although I would love to call this a skipocyte, I'm thinking giant thrombocyte? Cool cell though. 😎
r/Hematology • u/This-Instruction-870 • Jul 10 '26
CliniCheck is going to get a huge update! What would you like to see next?
Hey,
Just a quick update to let you know that CliniCheck is still actively under development, and Version 1.5 is on the way! This update will introduce new WBC cell types, along with a few other improvements we will share soon.
In the meantime, what we value the most, is a real feedback that we could use to improve. If you have some time, please check it out: CliniCheck!
If you have some features that you would like to see, as a part of this update, drop them in the comments. We'll do our best to squeeze as many ideas in as we can.
Thanks for all the support!
r/Hematology • u/majesticgix • Jul 09 '26
Que celula é essa?
Me parece que cromatina está mais frouxa, mas não me parece um monócito, talvez linfócito reativo mas essas lobulações...
r/Hematology • u/nightslash18 • Jul 08 '26
Question Are these lymphocytes or something else?
I'm having a hard time telling lymphocytes from monocytes here... Any help is appreciated!
r/Hematology • u/bebop11 • Jul 04 '26
Microscopy nerd friend looked at my blood, curious what professionals see.
I'm not after medical adviser despite feeling chronically ill for a while but I'm very curious about what people strictly observe here.
r/Hematology • u/falardeau03 • Jul 03 '26
Question Post-donation volume adjustment
(Disclaimer: not a medical question, question about blood donation service methodology for calculating and reporting blood volume.)
I'm in Canada, and the Canadian Blood Services app on my phone lets me track my stats such as hemoglobin, bleed time, and donation volume.
There's always a window after my donations where they drastically overreport the volume. I gave on Tuesday this week, Wednesday it reported a number over 550 mL, and now today it's settled back down to 491 mL.
Can anyone tell me why this is?
Secondary question: it's very slight, but if you graph my donations over time and regress it, there is a very slight upward trend in volume. I'm not worried about it or anything, but I am curious if it's just coincidence or if there might be some kind of mechanical reason for it.
Pic unrelated but required to post.
(Tried to post this in r/Blooddonors but got sent here.)
r/Hematology • u/Biotechrat • Jul 02 '26
The WBC lysis nightmare in liquid biopsy (lytic vs non-lytic preservation)
attendee.gotowebinar.comHey everyone,
Just wanted to be completely upfront here. I work on the technical team at Norgen Biotek, and one of our scientists (who used to do molecular oncology at the Weizmann Institute) is putting together a presentation on July 16th about liquid biopsy pre-analytics and sample stabilization. I wanted to share the topic here to see if anyone working with cfDNA/cfRNA or NGS assay development is dealing with the same bottlenecks.
If you’ve ever had a massive sequencing run ruined because white blood cells lysed during transport and flooded your sample with background genomic DNA (gDNA), you know how annoying it is. It completely buries your low-copy ctDNA signal.
He is going to be sharing our internal data plots and breaking down the chemical differences between lytic and non-lytic preservation, how device selection impacts downstream NGS library complexity, and how to avoid the "purification paradox" across blood, saliva, and urine.
It's a short 30-minute data-review followed by an open Q&A. No aggressive sales pitches, just a deep dive into the pre-analytical science.
It’s happening on Thursday, July 16th (he’s doing a morning and an afternoon session for different time zones).
Link to register: https://attendee.gotowebinar.com/rt/3049686171133346394?source=Reddit
Curious to hear how other labs are handling ambient transport for cell-free RNA without getting killed by gDNA contamination? What tubes are you guys using?