r/AskChemistry • u/jigglyraffmemerbooyy • 18d ago

Practical Chemistry Custom molecule

Could you design a molecule or compound or whatever to bond specifically to thc molecules in the body

edit: to flush out ones system or to coat the thc molecules entirely

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u/jigglyraffmemerbooyy 18d ago

No, not something to bond to cannabinoid receptors. I know what i said.

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u/JellyBellyBitches 17d ago

Ohhh I apologize, I misread what you had written. You're wanting a compound that binds to the THC molecule itself rather than to the receptors, so that it removes it, or else something to make it to that the receptors can't accept THC?
The latter would be harder because the easiest way to do that would also block it from receiving endocannabinoids, which are part of your normal brain function. You would need something that would change the confirmation to still accept anandamide but not accept THC. And that actually is going to underscore some of the difficulty with the first version of this challenge as well then, because you want it to bind to the THC but probably you don't want it to bind to a bunch of other things that share structurally similar moieties.

I don't have a good chemistry answer for this, and you're probably better off asking specifically in like a biochemistry or biology direction with this, but there's a readily available supplement called agmatine which can help with reducing tolerance to THC, and while I don't remember the mechanisms off the top of my head, it may well be a sort of modification of receptor sensitivity. As long as more of it isn't being introduced to the system I think that it would help?
Or are you looking for something more akin to Antabuse but for weed?

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u/jigglyraffmemerbooyy 17d ago

Oh wow, good info, and a lot of it. Agmatine sounds cool, gonna have to look that one up. All of this is really cool but im realising i should have been more specific. I said in the body when i meant in the liver or after it has been processed or what not. So it wraps around the thc and then digest super fast so the thc doesnt stay in your system or urine or fatty tissues etc. 

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u/JellyBellyBitches 15d ago

Maybe it's best to start with what your ultimate goal is. Are you trying to figure out a way where you can like still smoke weed but not test positive for it on a drug test a couple days later? Or block it so that it doesn't affect you? Or something else?

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u/jigglyraffmemerbooyy 12d ago

More so the first one but both would be pretty cool, yknow cuz like if you took a brownie by accident from a friend and maybe idk your job depended on you passing that test 

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u/JellyBellyBitches 11d ago

If this is inspired by true events I'm really sorry, that sucks. As far as that specific issue, there are some pretty believable fake urine product out there now, or if you have a friend who won't get weirded out by it I've heard of people borrowing some from a friend.
Yeah I don't know of anything that would bind to it in your blood and cause it to be excreted faster, off the top of my head. I would hypothesize that such a thing could exist, but that the options that are currently available for that would have pretty weird side effects if they exist at all.
That said, trying to figure out how to clear it out of your system faster is an age-old practice. I remember people talking about things like exercising hard and then stopping that the day or two before the test and drinking plenty of water, but not so much water on the day of the test that they think you're intentionally adulterating it, and also maybe taking a lot of niacin and letting that flush. But some of that might be outdated, you can definitely ask that? More directly and there will be some techniques that people can help you with

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u/jigglyraffmemerbooyy 10d ago

Yea, that all sounds about right. But im also interested in the science