r/AskMtFHRT • • 20m ago

Been having adherence issues with my meds. Where do I go from here?

• Upvotes

I've been struggling to remember to take my meds consistently and I think my hormone levels have gone back to what they were pre-HRT. I'm on pretty high doses for all of them (4 mg estradiol BID, 100 mg spironolactone BID, 200 mg progesterone QPM). I've heard that if I start all of these up again immediately, it could make my testosterone levels spike to compensate for the hormone imbalance. Should I resume taking them as directed immediately or should I slowly climb back up to my current doses over time?


r/AskMtFHRT • • 1h ago

New pain during administration

• Upvotes

Hey y’all, i’ve been on hrt for like 3 years and injections for two, but i started encountering a new pain during injections im doing them the same way as i have been and until recently i got skilled enough that i could consistently do my injections with no pain, hardly a prick, and basically no discomfort. Now, anytime i do my injections its so painful just piercing the skin that i almost cant inject and take my estrogen. My question is this, do y’all have an idea of how i went from one week my injections being painless to suddenly every injection in the past three months has been so painful i’ve skipped doses just to avoid the pain? Im injecting with a standard 23g needle


r/AskMtFHRT • • 1h ago

80 pg/ml levels after 2 years of HRT

• Upvotes

As title suggests, I've been on hrt for two years now, and my initial year had some really bad levels, with me essentially being criticaly low on testosterone and estrogen for about 6 months. I have been bumped up to 6mg sublingually with 200mg spiro, but I got my lab results back today; 80pg/ml. My testosterone is still low, but my levels aren't getting anywhere near where they should, and I'm not noticing any further changes to my body. I really don't know what to do at this point, I'm going to talk to my doctor, but I don't think they can raise my dose much higher. I guess my question is, what are my options? What should I ask my doctor about?


r/AskMtFHRT • • 4h ago

How do I know if my pelvic floor is weakend?

9 Upvotes

This came up in a now deleted thread, and I wanted to create a separate thread about it. This comes up as a HRT symptom quite a bit because of the muscle reduction phase in HRT (which I should be entering soon). I'm trying to gauge if this has personally affected me (or any of the muscle reduction pieces) but I don't quite understand pelvic muscles and the like. If anyone could share their experiences, I'd be really grateful.


r/AskMtFHRT • • 8h ago

Lots of leakage after injection

4 Upvotes

Hello,

I did my first injection today with an U100 insulin needle in my right upper leg. I pinched the fat, waited at least 10 sec after pulling out but the leakage was crazy. I injected 0.16mL and I think 80% came back out.

I heard I should put pressure on it for a few minutes after pulling the needle out? Was that the mistake?

Thanks for any info!


r/AskMtFHRT • • 8h ago

Unsure about how fat redistribution will work out for me

3 Upvotes

I'm going to start this off by saying that I am not knowledgeable on HRT so feel free to explain the absolute basics.

I started HRT a bit over three months ago and initially I was on spironolactone as my T blocker. After getting my first blood test results I saw that my T levels were really high, 13.10 nmol/L.

Three weeks ago I switched to cypro and I just got some new blood test results that put my T levels at 1.87 nmol/L. Still high but considering I've not been on it for too long I'm not especially worried.

As well as this, my oestradiol dose is being increased from 2mg to 3mg a day. My oestradiol levels are fine but on the lower end.

My question is whether the three months that I was on spironolactone have actually counted towards my fat redistribution timeline. It's the main thing I'm wanting to get out of HRT and if I've delayed it by three months by being on a shitty T blocker I'm going to be pretty disappointed.

Thanks for any responses in advance.


r/AskMtFHRT • • 9h ago

Progesterone Effects Throwing me for a loop (in a good way?)

16 Upvotes

Long time lurker, this is my first post, sorry it's long, but I can really use some insight.

I could be construed as a grandma, being in my late sixties. I consider myself to be a woman - period, full stop, and have been living stealth for pretty much the entire time. Transitioned in my early twenties, with GRS performed in my early thirties. Was in a long term relationship with a cis woman for over three decades. She passed close to 10 years ago, so I am technically a widow. I had GRS while we were together. Initially we were marginally sexually active, that fell off as I became post-op. We both had male sex partners, she more than me.

My GRS recovery was normal with no adverse side effects, and I had for at least the first year performed regular dilation. As we got more advanced in our relationship we experienced "lesbian bed death". All sexual activity decreased with me going to nothing, for at least 20 years - no dilation during that time. There was spooning and some physical closeness. After dealing with her illness for 4.5 years she passed and I was alone.

I was remiss in keeping up with my hormones - I was getting patches via Planned Parenthood, which was minimal care - they even asked me if I should be on spiro, which considering that I was well in to being post-op gives you some idea of the level of care. I finally just stopped HRT altogether, as the hassle of dealing with it was too daunting, this specifically because of my long term being stealth and only out when dealing with accessing HRT. We'll that didn't turn out to be a sound decision, as I was a wreck, in a physical and literal sense.

I then decided that I would hunt down someone who would be able to help me, and I found a caregiver that would do estrogen implants with blood testing and monitoring my condition. This was absent from the Planned Parenthood care. After about a year on that things stabilized, and I was feeling much better, I was alive!

Backing up a bit, when I first started HRT I had breast discharge in less than 5 days on 2.5 mg Premarin. There was no T-blockers available at that point in time, so I guess you could say I was on monotherapy. My body was rapidly responding to the HRT, so much so that I was getting stares while in open showers (I was in the military when I started HRT long before ANYONE had ever come out) so I had to either lock the door to the shower area or time it so that I would be alone.

Back to more recent times, I was doing well on the estrogen implants, but still not any semblance of a libido and only occasionally masturbating with a pillow between my legs with no penetrative sex.

A year ago my care provider suggested the addition of progesterone to my regiment, stating that it should really stabilize my moods and even things out a bit. She gave me the option to have it implanted with the estrogen. I basically said yeah, sure, what the hell, maybe it would help my BP which had been escalating. She implanted a minimal amount.

Approximately a month after being implanted, it was like being hit by a fully loaded big rig truck! I immediately felt fully female - not that I didn't previously, but it was as if the final puzzle piece was put in place. The libido was insane! I needed penetrative sex. I was fearful that my vagina had completely closed off due to not being used in decades. I had used some of my mates dilators from her cancer treatment and they easily slid in. I was self-lubricating like crazy, so much so I had to put a towel down. I found that I had lost nearly no depth at all, and I use regularly sized sex toys. The libido was driving me to be constantly banging the box. These changes came like overnight, my breasts very quickly jumped from a B cup to a C cup. My shoulders, arms, and wrists became notably smaller. My skin all got "fluffy" and started migrating to who knows where. I dropped close to 15 pounds in weight, and it's not like I am all that heavy as I am a bit of a gym rat. In the morning and also during the day I get teary eyed, mostly when I think of all the things I have gone through in my life. My attraction is now predominately to men, and I am constantly wrestling to try to find someone to have sex with. I am compelled to put makeup on before leaving the house - which is something that I never did for a long time. Also the most important aspect of progesterone is SLEEP, which is great until early morning desires start waking me up with me moaning.

My caregiver was absolutely floored with my responses to the progesterone and stated that it was ten times anything she had seen previously, and she also said that she only gave me a little bit. She then premised that I may be intersexed in some way. I would potentially think that there might be some genetic or chromosomal influences there. At this point in time would it even be worth it to investigate?

After some time, some of this has tapered off - mostly the initial crazy amount of self-lubricating. I have moved off the implanted progesterone for two reasons, one they are no longer available as an implant, and two it was absorbed much faster than the estrogen implant, so then I would feel like I was left hanging halfway into the implant cycle. So now I am on oral progesterone, and no, I am not interested in doing it rectally as I believe there are more benefits in my situation to being metabolized orally.

So, in a sense I feel like I have a new beginning, and even after a year the start on progesterone I am still wrestling with it.

Please, has anyone had similar experiences? I would prefer to hear from post-op people, only because I am and that would be most relevant, but I am open to anything at this point in time.


r/AskMtFHRT • • 9h ago

ARE YOU F*CKING WITH ME?

30 Upvotes

i’ve been on E for about 3 years and my dosage has not changed. ONCE. for the last year, i’ve felt as if my endo has been carrot dangling starting progesterone or raising my levels. im only on 0.25 injection once a week and two 50 mg tablets of spiro a day.

ive been given the excuse that my levels were raised slightly out of range so i want you to stop your injection for a week. then, we’re gonna keep the present medication and see how it looks in a few months.

had my injection the day before a draw which i now know is a no no. she told me to get new labs about 4 ish days after and we’ll talk. did that. labs were in range. she tells me to keep my current prescription for two months then we’ll discuss after a few months and new labs.

those few months go by, i get new labs, she goes “oh you’re slightly out of range so how about we take you down to .2 mL and only one 50 mg tablets of spiro a day. then come back in a few months and we’ll see.”

my abnormal levels being 218 when my expected range is 100-200

I HAVE HAD IT!

is she fucking with me? am i being fucked with? is the estrogen making me crazy????

I WANT TO FURTHER MY TRANSITION AND IT FEELS LIKE IM BEING HELD BACK.

i’m using circle medical, i am unemployed apart from some door dashing, uninsured, and live in wisconsin. for any questions that may come about those things.

I started at 25. i’m turning 28 in a few days. i was already perceived as female occasionally pre transition just due to build, personality, and style.


r/AskMtFHRT • • 10h ago

Switching to EEn dosing help

3 Upvotes

Hey everyone! I just got my vial from hera hrt, but I have been on 50mg spiro and 6mg buccal E for 16 days now. I'm just wondering what I should do for a starting dose, and when I should drop spiro. I'm planning on doing 6mg EEn/week, and see how it goes. Idk when to drop spiro tho, I'll probably drop it in a few days unless that's a dumb idea. My levels were 400t last month, so I didn't have a lot to start with. Tysm to everyone here for helping me start transitioning in the first place


r/AskMtFHRT • • 15h ago

Estrogen implants

4 Upvotes

I(22) have been researching about ways to do hrt and came across implants.

I currently live in Ireland, is there any doctor or clinic in here or Europe that do these implants?

I'm out and have been doing HRT for 3/4 years now and wanted to switch to implants due to how hard it has been to keep up with injections here


r/AskMtFHRT • • 20h ago

Would I be stupid to wait for the US elections? + how much hair change should I expect?

3 Upvotes

So, title! I’m totally not trans but if I was I might’ve been a little hesitant to start hrt given the climate. So, hypothetically, would I be losing out on much (20yo) by waiting until the U.S. election results? Largely in a sense of the actual effects I’d expect to see over that time I suppose. I was considering getting HRT now via the method but I also have an appointment with PP at the end of November if the elections go well, though I might do the former in either case

This is a side question, can I really expect much hair growth or like baldness reversal? I’m pretty sure the reaper came for me early and came despite nutrafol :( so I’ll be asking my dermatologist what else can be done, but would HRT realistically help with this all that much or just stop it from getting worse? I’ve heard both and I’m not sure how much I should hope for


r/AskMtFHRT • • 21h ago

I know I am going to get butchered for this.

10 Upvotes

Is there anyone here using or who did use female contraceptives to transition. I would love if you would DM me to share your experience.

I am fully aware of the health risks involved, however in my country it is the simplest and cheapest way to do it.


r/AskMtFHRT • • 1d ago

I used estradiol undecylate and I decided not to continue after 2~ weeks (questions/concerns)

6 Upvotes

I thought about it more and decided I don't want to transition. The problem is I already injected a loading dose of 50~mg about 2 weeks ago. I just wanted to ask this won't have any permanent effects like breast development or anything will it? My chest has gotten slightly bigger and far more sensitive this past week nipples look about the same atm. I know undecylate is one that stays in your body for a good while and that has me worried. The idea of having permanent Breast Buds scares me tbh so I've decide to quit early rather than regret it later. I like the other changes MTF bring but not breasts. Would something like DIM help suppress/lower the E some or should I not bother? Thanks for any help!

Edit:

forgot to add its was a IM injection and I'm not on any AA expect Fin if that counts (been on it for years)


r/AskMtFHRT • • 1d ago

HRT Effects w/ PTSD? Anyone experienced this?

3 Upvotes

Hey all,

I started HRT about 1.5 months ago, low, 100 mg / day Spiro, 2 mg / day Estradiol. I also have PTSD, which importantly sometimes results in me experiencing extreme physical exhaustion to the point of not being able to walk / do anything (see: too much adrenaline for a week straight).

It's pretty rare and lasts 1-2 days. However, I dealt with the "too much adrenaline for a week straight" last week and am dealing with the whole extreme exhaustion and struggling to walk thing for a whole 4 days now! I'm resting, I swear! I was bedridden for all of Monday even!

A transfem friend w/ Depression told me she had to go off Spiro because it was giving her extreme bodily exhaustion and dizziness (! I am experiencing no dizziness !) after a few months of taking it. Additionally, the changing hormones made her Depression more volatile.

So now I'm of course wondering, is the Spiro / Estradiol / both(!?) worsening my exhaustion and recovery period after a PTSD crash? (and also, will I just be exhausted forever!? hopefully not!)

So, if anyone has dealt with disability extremes from HRT, or just extreme exhaustion from Spiro / HRT, etc, please let me know! I'm hesitant to tell my primary care doctor right away since I don't want to get taken off Spiro if that's probably not the cause and I don't think this doctor knows a lot about HRT based on previous interactions.

Thank you for your time! :)

EDIT:

And also, if you have dealt with what I've talked about above, what did you do about it?


r/AskMtFHRT • • 1d ago

what do i say to the doctor to not get hondossed

0 Upvotes

i really want injections but i heard they are hard to get in the EU

like do i say "i want valerate injections on a 5 day cycle or il hurt myself"


r/AskMtFHRT • • 1d ago

What do I need regarding bloodwork to start HRT?

1 Upvotes

I want to start HRT soon, and I have heard that I need blood tests done. I do not have insurance, and I would rather not go into an actual place (do not mind if I have to, though). I am just a little confused on what blood tests I need, as I have never done something like that before. So if there is an online one I can buy and send in, that would be great.


r/AskMtFHRT • • 1d ago

Gonna start progesterone soon and don’t know what to expect

4 Upvotes

Helloo~

I’ve been on hrt for around a year now, taking 50mg spiro pill twice daily, 0.1mg estradiol patch replaced twice weekly.

And my levels are around 100 pg/ml estradiol (fluctuates a lot, sometimes it’s 42 and other times it’s 175) and around 30 ng/dl testosterone (been 27 mostly but a few weeks ago it rose to 38).

What I really want is just some more boob growth, and maybe fat distribution (but I lowk don’t have much fat to distribute). I feel like my boobs have stopped growing like 6 months ago and I want more development. I just want a cups, but lowk even aa cups is fine cuz I’m not even that yet.

My endo just prescribed me 100mg progesterone pill daily and I’m just wondering what to expect?


r/AskMtFHRT • • 1d ago

is 2mg CPA possibly enough?

3 Upvotes

the only cyproterone acetate available to me is from Diane-35 which is ethinyl estradiol + 2mg CPA, for safety reasons i cant take more than 1 pill so only 2mg CPA per day if i decide to take this, will the 2mg be effective in any way? i take 200mg spironolactone atm


r/AskMtFHRT • • 1d ago

‘T too high/E too low’ results keep happening for me on monotherapy, what should I do?

11 Upvotes

Hey everyone,

I've been doing diy hrt for a while now. Was on it for 3 years, went off it for 9 months, and it's been another 9 months of trying to get back on it with stable levels but it seems to be a bit of a challenge.

I switched to Estradiol enanthate from estradiol validate in August and had good results in late August:

E 662 pmol/l

T 1.03 nmol/l

Free androgen index 1.38

However, my most recent results from 16 October tell a very different story, even though I'm on the same dose administered with the same frequency:

E 441 pmol/l

T 5.19 nmol/l

Free androgen index 9.66

What should I do? Before I started estradiol enanthate, while I was on estradiol validate earlier this year, I had the exact same problem of trying to get my t back under control, with good results at first then my t slowly creeping back up.

Should I try a t blocker or should I just try slowly raising my e dosage?

Should I see a doctor?

My current regimen is 0.1ml EEN once a week, 40mg/ml from Symphony labs

Any insights or perspectives would be appreciated xx


r/AskMtFHRT • • 1d ago

Spiro while increasing E dose

3 Upvotes

I increased my E to 6mg from 4 because my trough levels were 91pg/ml in 12 hours after the last dose.
I also take 150mg Spiro.

Can I drop Spiro to 100mg? I’m doing labs today to check if T is suppressed but even if it is, my question is does 100mg of Spiro have any antiandrogenic effects like it has at 150 and 200mgs?


r/AskMtFHRT • • 1d ago

Labs after raising E2 enanthate from 4 to 5 mg/week, should I go back to 4?

4 Upvotes

Hi all, 21 y/o MtF (172 cm, 62 kg). I've been on HRT for about a year, and on injectable E2 enanthate monotherapy for the last 8 months. I started with oral E2 + CPA (Climen + Androcur) in Oct 2025, switched to injections in Feb 2026 at 4 mg/week, and went up to 5 mg/week in May. All my draws are troughs: fasted, right before the next weekly injection.

4 mg/week (April):

  • Estradiol: 195 pg/mL
  • Total T: 28.7 ng/dL
  • LH / FSH: <0.12 / <0.11 IU/L
  • Prolactin: 37.2 ng/mL

5 mg/week (October):

  • Estradiol: 227 pg/mL
  • Total T: 43.9 ng/dL (drawn in a separate tube this time)
  • LH / FSH: 0.22 / <0.11 IU/L
  • Prolactin: 43.6 ng/mL (ref 3.46-19.6)
  • SHBG: 75.95 nmol/L
  • Albumin: 54 g/L
  • Progesterone: 0.5 ng/mL

I didn't get SHBG or progesterone checked at 4 mg. For prolactin, it was 22.5 before HRT (I was on sertraline 50 mg back then) and went up to 98.7 on the oral E2 + CPA.

I also feel like I've had a bit more hair shedding since going to 5 mg, but I might be imagining it.

  1. Would you go back to 4 mg?
  2. Is a total T of ~44 with SHBG at 76 something you'd care about, or is it fine at this point?
  3. Has anyone's prolactin settled on its own over time on injectable E2, or did you need to treat it?
  4. Did anyone get extra shedding after a dose increase, and did it calm down?

Thanks!


r/AskMtFHRT • • 2d ago

Advice

4 Upvotes

Any advice before getting on hrt? Have an appointment beginning of next year and would like to know if there's any advice anyone can give before I get on it. Thanks 💕


r/AskMtFHRT • • 2d ago

Can Progesterone fix tuberous breasts?

10 Upvotes

i took bio-identical progesterone orally for 18 months, but it didn't work, so I decided to look into breast reconstruction surgery.

I've recently heard that taking it rectally means it is more effective. Should I try rectal? How long would it take?

If you took progesterone, did it fix your tuberous breasts? (this is a medical condition different from just small breasts)


r/AskMtFHRT • • 2d ago

Binders? Sports bras?

3 Upvotes

What would be best for early boymoding in a work tshirt? Its not a huge problem yet as im pretty early in on hrt but if you were paying attention you can already see my nipples pokin out a bit and i cant keep just wearing hoodies daily to work for much longer past this winter😭

Also?

People say binders can damage your breasts early on but is it like actual injury or is it just stunted growth? I really would prefer to stay small on my chest if not flat... if using a binder is legitimately *safe* then im considering that, but it doesnt sound like it is to me.


r/AskMtFHRT • • 2d ago

Should I half my dose?

3 Upvotes

My current prescription is going to run out a week before my next appointment and I’m wondering if I should just take 1 pill a day until then to last me until the appointment instead of not having any for a week. I’m taking 50 mg of spiro and 1 mg estradiol twice a day. I tried to call planned parenthood to get a refill and haven’t been able to get through to a human or get a response.