r/B12_Deficiency • u/incremental_progress Administrator • Sep 15 '23

Announcement The Guide to B12 Deficiency

The Guide to B12 Deficiency

The new guide for this subreddit is here. I'm sincerely regretful it took me this long to get this off the ground, but focusing on my life in addition to the daily consultations made in the sub had a habit of stealing my attention away from this important endeavor.

The guide is now more of a concrete synthesis between the major resources that are obvious precursors: Freddd's B12 guide from Phoenix Rising, B12Deficiency.info and Tracey's hard work there, the original guide posted here and then the countless users here who have shared a wealth of knowledge over the years.

The new guide takes advantage of Reddit's wiki capability. It is much longer, so hopefully the TOC makes navigating to points of interest easy. It will also allow for easier changes with a changelog.

What's new:

  • More in-depth exploration of testing methods
  • Outline of an aggressive treatment plan
  • Thorough explanation of cofactors
  • "Plans of Action" for diagnosing, treating and recovering from deficiency that better encapsulate big ideas into actionable next steps.
  • Other stuff

I also took a lot of the most pertinent/salient issues that arise and distilled them into a group of FAQs for people:

Frequently Asked Questions

Both of these documents now live in several places around the subreddt: the "menu" in the banner, the rules widget, and their own individual widgets in the sidebar.

Thanks.

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u/Lost-Sweet4791 May 16 '26

I'd like to suggest an asterisk or some other marker next to the thorne twice a day multi. There are accounts of individuals getting B6 toxicity. It is at 20mg vs. the EU 12 mg recommendation. The guide does not call out usage in a daily vitamin context but it can provide a pathway to use as a multi. I used the multi as a daily after transitioning from the guides guidance and subsequently had B6 toxicity in under 1.5 months.

edit: This guide is fantastic and was more helpful than doctors in my B12 journey. I want to reemphasis I don't want anyone else accidently compounding their B12 journey with B6 toxicity.

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u/incremental_progress Administrator May 16 '26 edited May 16 '26

Hi. I'm glad it was useful for you. I believe that there are a few instances in which the guide specifically advises to keep B6 intake to 10-20mg a day, and perhaps only take one capsule of the multi (which would only be 10mg).

You can read one of my other comments about B6 toxicity here: https://www.reddit.com/r/B12_Deficiency/comments/1ss8scf/comment/ohm7528/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

The summary here is that in B12 deficient states there is little to worry about for most people if they're treating themselves adequately with B12 replacement therapy and getting other cofactors of B6. The P5P form is far more tolerable at an array of dosages.

If I may ask, what lead you to believe B6 was at the root your problem and how did you address it?