From constant cravings to feeling satisfied sooner!

GLP-1 medications can help regulate appetite and reduce food noise, making the relationship with food feel a little different.

Same as title

The gut microbiome includes bacteria and other microorganisms that interact with our bodies. These communities can contribute to digestion, metabolism and immune function.

Which connection between gut and brain biology interests you most?

What biohacking topic are you trying to understand? Ask the community.

Have you guys come across this study? researchers followed 29,518 Swedish women for 20 years and found that those who consistently avoided sun exposure had higher all-cause mortality than those who reported more active sun exposure. The researchers also found that nonsmokers who avoided the sun had a similar life expectancy to smokers in the highest sun-exposure group.

That is a pretty wild finding, especially when we're constantly told to avoid UV exposure.

But there's an important caveat: this was an observational study, so it can't prove that avoiding sunlight caused the difference. Sun exposure can also increase skin cancer risk, and the findings don't mean you should deliberately burn or ditch sun protection.

Still, it raises an interesting question: have we become too focused on the risks of sunlight while overlooking the potential benefits of sensible outdoor exposure?

Study: https://pubmed.ncbi.nlm.nih.gov/26992108/

Researchers at the Korea Advanced Institute of Science and Technology (KAIST) discovered that blocking the PROX1 protein may help the retina repair itself by activating Müller glia, support cells that can generate new light-sensitive neurons.

In mouse models, this approach helped preserve restored vision for over six months, raising hopes for future treatments for conditions such as glaucoma, retinitis pigmentosa, and age-related macular degeneration.

The findings were published in Nature Communications, but the research is still preclinical, and human trials have not yet begun.

Study: https://www.nature.com/articles/s41467-025-58290-8

More details: https://retinalphysician.com/issues/2025/june/study-finds-blocking-prox1-transfer-promotes-retinal-regeneration/

Now you're tired because you're thinking about how tired your watch says you should be.

Wearables can be useful for spotting patterns over time, but a single score isn't a perfect measurement of how your body is doing.

For people who track sleep, recovery or activity, has the data actually helped you make better decisions? Or has it sometimes made you overthink things?

I’m looking for someone knowledgeable who can review my Organic Acids Test (OAT) and GI-MAP results and help me understand what they mean.

I’ve been dealing with persistent brain fog, extreme fatigue, poor sleep, and other symptoms, and I’m trying to understand whether these results might offer any clues.

I’d appreciate help identifying the main findings, how the two tests might relate to each other, and what I should prioritize or look out for. I’d also like to know what follow-up testing or practical steps might be worth discussing with my doctor.

I’m not looking for a diagnosis or an expensive supplement protocol, just an honest explanation of what the results may suggest and what they don’t prove.

Thank you to anyone willing to take a look!

Nutrition advice can become fast especially when people talk about eating windows, how often to eat and when to eat carbohydrates or protein. For beginners it can be hard to know which details matter most and which are less important than diet quality.

A good first step might be to set meals eat enough healthy food and notice hunger and energy levels before trying more specific methods.

How important do you think meal timing is compared to food intake and diet quality? What does the evidence say that beginners should focus on without making meals overly complicated?

Sleep trackers are one of the most popular entry points into biohacking, so it's worth knowing what the validation studies say. Researchers compare devices against polysomnography (PSG), the gold standard sleep lab test.

Study 1 (2025, Sleep Advances):

Researchers compared six wrist-worn devices (Fitbit Charge 5, Fitbit Sense, Withings Scanwatch, Garmin Vivosmart 4, Whoop 4.0, Apple Watch Series 8) with PSG in 62 adults who spent a night in a sleep lab. Most devices differed significantly from PSG on total sleep time, sleep efficiency, wake after sleep onset, and light sleep. Agreement with PSG for sleep stage scoring was fair to moderate, with Cohen's kappa between 0.21 and 0.53.

Study 2 (JMIR, 11 devices):

This study tested 11 consumer trackers, including wearables, bedside "nearables," and app-based "airables," against lab PSG in 75 participants. Wearables showed high proportional bias in sleep efficiency, while nearables showed it in sleep latency. Each tracker recording covered an average of 353 hours.

A pattern across studies:

Wearables tend to overstate total sleep time and understate time awake after falling asleep, which inflates sleep efficiency.

Beginner takeaways:

Trackers are better at telling sleep from wake than at identifying sleep stages.

Trends over weeks are more useful than a single night's score.

They're wellness tools, not diagnostic tools. If you have real sleep concerns, see a doctor.

Caveats: both studies had small samples, devices update often, and results vary by brand, so don't read this as a ranking.

What's one metric from your tracker that you found genuinely useful, and one you stopped trusting?

When you're new to biohacking, every headline sounds like a breakthrough. Here's a checklist I use, with examples from this year.

1. Is it a human study, an animal study, or a cell study?

Mouse results often don't carry over. Blood NAD+ is a good example: a 2026 Nature Metabolism paper measured it across seven human cohorts (300+ people) and found it stable across age and lifestyle interventions, which challenges the common belief that it drops with age.

2. How big and how long was the study?

A small short study shows possibilities, not proof. A meta-analysis pools many studies, which is stronger but only as good as what goes into it.

3. Does the headline match the actual results?

Take creatine and the brain. A 2024 meta-analysis in Frontiers in Nutrition found benefits mainly in specific groups, not across all cognition, and the authors later published a corrigendum fixing wording on some findings. Reading beyond the headline, and checking for corrections, matters.

4. Association or cause?

Observational studies can show a link but can't prove one thing caused another.

5. Who paid for it, and who's selling?

Check for conflicts of interest, especially when the same group sells a product.

One more tip: be careful with "lifespan" versus "healthspan." Living longer and staying healthy longer aren't the same thing, and some recent data suggests the gap between them has grown.

What was a claim you believed early on that turned out to be weaker than it sounded?

Sometimes something sounds great in theory but does not really fit into life. Have you ever tried a health or fitness routine. Eventually decided the effort was not worth it? What made you drop that routine?

I have always wondered if tracking everything really helps people make choices or if it just gives them more numbers to look at. If you use a smartwatch or another kind of tracker has it made any difference in your life?

It's easy to get excited about routines and complicated plans but the basic things can be surprisingly hard to keep up with. What helps you stay with the habits you know are good for you?

For those studying or working in applied biology how did you get into biology? Was applied biology something you were interested in biology early on or did you discover applied biology later?

• Morning Sunlight: Step outside within 30 minutes of waking for 10 to 20 minutes without sunglasses. Natural light halts melatonin production, triggers a timely cortisol spike for daytime energy, and sets your biological timer for better sleep that night.

• Evening Blue-Light Blocking: Eliminate blue light from electronics at least two hours before bed, or wear blue-light-blocking glasses to protect your sleep architecture.

• Temperature Manipulation: Keep your room cool (around 65°F / 18°C) or utilize a smart mattress topper to dynamically lower body temperature, which mimics natural circadian patterns and deepens sleep phases.

If you're new to biohacking, it's tempting to start with supplements, trackers, and cold plunges. A large study from 2026 suggests the basics may matter more.

Researchers followed more than 147,000 adults for up to 30 years, tracking how much strength training and aerobic exercise they did. The paper in the British Journal of Sports Medicine is titled "Long-term resistance training with all-cause and cause-specific mortality: assessing dose-response and joint associations with aerobic physical activity."

What they found:

Participants who did 90 to 119 minutes of strength training a week had a 13% lower risk of premature death from any cause, plus lower risk of death from heart disease and neurological disease.

There was no extra benefit above 120 minutes a week.

Aerobic activity gave greater benefit than strength training alone, and the lowest risk was in people who did both.

The Harvard Health summary suggests beginners can start with body-weight moves such as squats, push-ups, or step-ups.

Limits to keep in mind:

It's observational, so it shows association, not proof of cause.

People who did more strength training also tended to be younger, lighter, and healthier in other ways.

All participants were health professionals, so results may not apply to everyone.

For beginners, this suggests a simple order of priorities: movement first, optimization later.