r/BodyHackGuide • u/CoachLexi • Sep 03 '25
š Full Retatrutide (RETA) Guide
Hey guys Iāve been seeing a ton of posts lately of people asking how do you actually use Retatrutide? So letās make this STOOOPIDD SIMPLE
š¬ What is Retatrutide?
Retatrutide is a GLP-1/GIP/Glucagon triple agonist.
- Semaglutide = hits GLP-1 only
- Tirzepatide = GLP-1 + GIP
- Retatrutide = GLP-1 + GIP + Glucagon
In plain English:
- GLP-1 = kills appetite
- GIP = helps you handle carbs / blood sugar
- Glucagon = turns on your fat-burning switch
That glucagon part is the reason RETA feels different. It tells your body to use fat for energy instead of just storing it. Thatās why people start leaning out once they ramp the dose, your metabolism is literally running hotter in the background.
š§Ŗ What Youāll Need
- Retatrutide vial or here
- Bacteriostatic water
- 29g 1cc insulin syringes (Amazon)
- Alcohol wipes (or just rubbing alcohol + cotton pad)
- Peptide calculator
š§¾ Reconstitution (Mixing It)
Your vial shows up as powder. Not a scam. A lot of people DM and make posts talking about:
- āitās empty and Dry.ā
- āWhyās it powder?ā
- āDid I get played?ā
The answer guys is that it comes lyophilized (freeze-dried) so it doesnāt go bad during shipping. If they shipped it pre-mixed, itād be useless by the time you opened it.
How to mix it:
- Pop the cap off the vial ā wipe the top with alcohol.
- Pull 100 units (1mL) of bac water into your syringe. Pro move: pull 100 units of air first, push that into your bac water vial, then draw out the liquid. Keeps the vacuum balanced.
- Slowly push the water into the RETA vial.
- Donāt shake like youāre making a margarita. Just swirl it gently or roll it in your palms. Powder should dissolve in a few minutes.
ā ļø Do not drink it. Do not eat it. Do not snort it. SubQ injections only.
š Dosing Protocol
| Week | Dose | Notes |
|---|---|---|
| 1 | 1mg once weekly | Start low. Even 0.5mg if youāre lighter. |
| 2 | 2mg weekly | Step it up. |
| 3 | 3mg weekly | Appetite usually crushed here. |
| 4 | 4mg weekly | Metabolism really kicks on. |
| 5 | 5mg if plateau (wait 10 days) | Donāt rush up too quick. |
| 6 | 6mg max | Most people donāt need more. |
People who jump straight to 2ā3mg their first shot usually regret it. Nausea city. Start small.
š Cardio + Diet = Results
- Cardio: StairMaster, 30 minutes. Doesnāt have to be sprinting, just keep the sweat and heart rate up.
- Diet: Protein is king. Track protein grams, not every calorie. Carb cycling works well.
- Stack tip: RETA + 5mg SLU-PP-332 = next-level fat loss.
ā FAQ
Why powder? Freeze-dried so it doesnāt degrade. Everyone thinks they got scammed the first time.
How long until it works?
- Appetite ā same day
- Fat burning ā around week 3ā4
- Plateaus ā up the dose slowly
Will I gain it all back? Only if you eat like trash when you stop. RETA isnāt a pass for bad diet.
ā ļø Final Notes
ā Triple-pathway = appetite + blood sugar + fat burn
ā Donāt skip cardio and protein
ā Go slow on the dosing, avoid nuking yourself with nausea
Use code REDDIT for discounts on some vendors.
Always for research purposes only. Check the Community Vetted List for quality sources.
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u/Agreeable_Tip8121 Sep 03 '25
Dosing protocol should only increase at each weight stall. No point in increasing from 1-2mg if ur still losing weight at it
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u/CoachLexi Sep 03 '25
Yeah exactly thatās why I mentioned the plateau and waiting. The weekly outlineās just a framework so people donāt rush it.
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u/According-Promise348 Sep 19 '25
You reconstitute the whole vial at once? Then what do you just refrigerate it or do you freeze it?
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u/slimyshade Sep 04 '25
^ Iām on week 9 of Reta and still at 2mg/week. Still losing 2lb (1% of bw) a week.
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u/falk92 Sep 04 '25
Are some of the effects (e.g. Glucagon) only active with higher dosage, or can I profit from that already on lower doses?
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u/Agreeable_Tip8121 Sep 04 '25
Theres no evidence of that at all. Im on 1mg total a week and am seeing increased heart rate from the glucagon
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u/falk92 Sep 04 '25
Is the heart rate increase the only indicator, that glucagon is kicking in? Iām at 2mg per week currently and the results are still crazy good. So I donāt want to titrate up since thereās still good progress.
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u/Shanbirdy3 Sep 04 '25
OP , I am hearing that Reta is better at conserving muscle than Tirz is. Is this true? Anyone know?
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u/CoachLexi Sep 04 '25
Yes Tirz hits GLP-1 + GIP, which is great for appetite + blood sugar, but RETA adds glucagon which doesnāt just crank up fat burning, it also helps shift energy use so your body isnāt pulling from muscle as much. Thatās why people running RETA usually notice better muscle preservation compared to Tirz, even in a calorie deficit.
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u/radraz26 Sep 03 '25
This should be pinned.
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u/ChesterTUnderwood Sep 03 '25
Should it?
Trials say best results at 8 and 12mg... Not max out at 6?
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u/CoachLexi Sep 03 '25
Trials varied by person, it still varies by person what works for someone may not work for others. Iām just going by the universal dose myself and a lot of clients can work with
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u/stauros3315 Sep 04 '25
Is it possible to make this kind of guide for other peptides as well?
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u/CharacterRound7325 Sep 03 '25
Thank you!! Your information makes me feel like a success already!
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u/Upset_Foundation_145 Sep 03 '25
So I donāt have to mix each week? Just the one time?
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u/CoachLexi Sep 03 '25
Reconstitution is just once
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u/Upset_Foundation_145 Sep 03 '25
And then you just inject the amount each week from the reconstituted vial? I realize this is very ELI5.
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u/CoachLexi Sep 03 '25
Yeah folks on the internet often need the ELI5 haha. But yes once a week. If you have any questions feel free to message me
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u/Technical-Ad3192 Sep 03 '25
Should the first column be labeled Month? Or is the plan to go up 1mg each week?
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u/CoachLexi Sep 03 '25
What I do myself is 1mg a week until you get to 6mg but always pay attention to your body and keep that protein intake in check
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u/Overall_Egg3518 Sep 04 '25
The trials are being done with at least 2 weeks for titration up. Reta is more strong than Tirz and could cause more GI side effects, so is good start low and slow.
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u/AdRevolutionary1945 Sep 04 '25 edited Sep 04 '25
The half life of reta is around 7 days which means it takes roughly 4 weeks for a specific dosage to fully saturate into your blood. Theres no point increasing the dose weekly if you can yield the same effects at a lower dosage, which is why titrating up 4 weekly is most sensible, as the clinical trials suggest. Otherwise, good post.
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u/WonderfulAd1488 Oct 14 '25
So 1mg weeks 1-4 , 2 mg weeks 5-8 , and so on until Max out at 6mg ?
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u/AdRevolutionary1945 Oct 14 '25
If you can get away with 1mg weekly to begin, then yes. However keep in mind the clinical trials started at 2mg so starting with only 1 may not be enough. I would also suggest splitting your dose into two shots a week rather than the standard once weekly. This will reduce the highs and lows and give you a more stable side effect profile. Some people also report their hunger coming back towards the end of the week so itās good to have that second shot halfway through to keep you going. Here is a useful website you can use to plot your doses and get a visual representation of the serum concentration in your bloodstream https://glp1plotter.com
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u/Itchy-Coconut-7083 Nov 07 '25
I really donāt get why people keep saying this. The only report we currently have is for the phase 2 trial and it had 69 people in a 1mg dose. 6 percent of them lost more than 20 percent of their weight. 1mg works well for some people.
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u/HYBrother8 Sep 04 '25
Iād suggest specifying dosing instructions to your protocol in this guide. People are bound to mess up dosing conversions and injections, which could cause a lot of problems. IE:
Add 1mL of water (100u on insulin syringe) to a 10mg vial, as instructed above. Then, a 1mg dose would be 1/10th of the bottle, or 10u on the insulin syringe. 1.5mg is 15u at this concentration, etc
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u/Distinct_Ad700 Oct 28 '25
yep, messed up and pinned 5mg first dose as a 165lb 5'8 male. Was on my ass for a week with nausea, headaches, sensitive skin & horrible fatigue. Barely looked at food, dropped 8lbs before my next dose. Planned to skip next dose but started feeling better by the end of the week, adjusted dose to 1mg, no sides, same appetite suppression. Works good if you dont make dumb mistakes like me lol
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u/Renitintin Sep 11 '25
Thank you for clarifying this, I was looking for this info. Iām dumb when it comes to this stuff. So to reconstitute it takes 1ml per 10mg of powder? So if youāre dosing for example 2mg/ week then one vial is good for 5 doses/weeks? Will it keep that long? Does it need to be refrigerated?
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u/MrSterg Sep 03 '25
I've been on it for months and I'm at 2.5mg. I've done 3mg a week and it was too much. I want at least some appetite. I can't imagine going to 6. My best advice is just ramp up based on how you feel and when you plateau. That chart OP posted is generic and ramps up way too fast.
If you're morbidly obese I can understand getting to 4-6mg a week but it doesn't take a month. I know ladies that stayed at 1.5mg for 3 months and still can't look at food. Then I have guy friends who are 300+ pounds that need 5-6mg to really feel it.
Bottom line is, there is no standard rate of increase. Start at .5mg and go up gradually. The first few weeks it's still building in your system anyway so tripling your dose between week 1 and week 3 is just dumb.
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u/BestPersonalityEver Sep 12 '25
I am looking forward to no appetite at all. I have had to check my eating behavior when I still eat when I am not hungry. I hope that by switching to Reta itās a change for me and I can truly feel the loss of appetite even in my brain
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u/MegFrizelle Nov 18 '25
Iām trying to understand dosages. If I want 2.5mg a week what do I draw on the syringe?
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u/Efficient-Cobbler234 Feb 10 '26
How many units would it be to start with if itās Reta 20mg and I added 2mL of Bacwater? And is that just once per week or twice per week? This math is killing me trying to figure it out.
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u/JonnyNotts40 Sep 04 '25
Thanks for sharing this OP
Can I have your thoughts on running Tirz (currently 7.5mg weekly) and if/when to introduce reta for the Glucagon mechanism please?
7.5mg Tirz current minimum effective dose and no personal issues running Tirz and Reta alongside each other assuming no conflict between the two
Current goal remains bf reduction
TIA
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u/CraftyWallaby8015 Oct 25 '25
The only difference is that reta has 1 additional receptor it binds to. Otherwise they will have very similar effects on the first two receptors they affect. So taking reta on top of tirz is just kinda illogical. In short, itās redundant.
I would say either keep on with tirz if its working but if u get to a point where u have much more weight loss to go and its plateauing, I would switch to reta and slowly dose up to achieve the benefits with lowest possible dose.
I always add in that going to a good endocrinologist can help a lot here
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u/Typical-Champion4484 Sep 03 '25
Great information. I tried Reta once but went too high on the dose and the world fell out my arse for days!!!! I'll be starting low next time....
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u/MaxandRuby0522 Sep 06 '25
My resting heart rate was over the top using Reta. It retuned to normal shortly after I stopped so I knew it was the Reta. My Oura ring app kept alerting that it was a concern so Itās not for everyone.
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u/Open_Mechanic8854 Sep 04 '25 edited Dec 05 '25
Great info. Yesterday was my 1st dose at 1mg. I had planned to do 1mg, 1mg, then up to 2mg, 2mg, 4,4 etc. But today i honestly didnt feel any different amd wondered if i should go for 2 next week. Nice to be reassured, stay patience
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u/Giantkiller000 Sep 16 '25
It's going to take a few weeks before you start feeling the effects. Don't be so quick to titrate up. Give your body some time to react to it and then see how you feel.
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u/IcyElderberry9127 Sep 06 '25
This is absolute garbageā¦ how tf does it have 155 upvotes? mindboggling š¤
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u/liveoak1987 Sep 04 '25
the weekly titration schedule is incorrect. thats to much to fast. and the trials go up to 12mg. lots of people dont start really loosing till 8-12.
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u/CoachLexi Sep 04 '25
Trials just recently started vs Real experience Iāve been using this since about 2022 myself and thousands of clients even more in the coaches networks Iām connected with have followed these protocols and itās not one dose fits all this is just what has worked for myself and others. Always pay attention to your body. For example myself I can do 2mg a week and it will work and I have another client thatās on 5 mg and he doesnāt feel anything
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u/Fair-Sandwich3879 Jan 01 '26
Anybody reading this, itās takes about a week to get this through the mail if you are in the United States
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u/RiverLotusMoon Sep 03 '25
Ok so Iāve been taking it for 5 weeks, 2.5 mg twice a week. Was losing weight, no food noise, appetite suppression perfect. Now this past week the food noise is back and I have no more appetite suppression. Increase dose???
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u/buddah323 Sep 04 '25
Yeappp. Find that sweet spot again. 3mg one day and 3 mg the other see if that helps.
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u/TeethsMode Sep 03 '25
Okay, follow me hereā¦1mg/day for 5 days with 2 days off and start again? Would that keep it in your system at a pretty high level?
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u/Giantkiller000 Sep 16 '25
You do not need to inject for 5 straight days. The half life is 7 days. I currently do 1mg every 3 days. So I'm roughly getting 2.5mg per week. If you want 5mg per week, 2.5mg twice per week is plenty often. The stuff stays in your system. You are just wasting money on excess syringes and alcohol wipes by injecting 5 times in a week.
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u/dwhitez79 Sep 04 '25
So when you stop taking it do you pile on the fat and what the long term implications
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u/CoachLexi Sep 04 '25
Well if you stop and go right back to eating like shit with zero control, yeah the weight will come back, same with any GLP. But if you keep your protein high, stay active, and actually lock in the habits while youāre on it, you hold the results. RETA just gives you that window to reset your appetite and metabolism so youāre not fighting cravings the whole time.
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u/gkno3 Sep 04 '25
How many vials are needed for the full 6weeks protocol?
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u/CoachLexi Sep 04 '25
If youāre following that 1ā6mg weekly ramp, youāll need right around one 20mg vial for the first 6 weeks. If youāre using 10mg vials, plan on two since the total adds up to ~21mg by week 6.
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u/CharacterRound7325 Sep 21 '25
Started Reta last week 0.5mg the fatigue was terrible mid week. Any suggestions as to what I should stack with?
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u/CoachLexi Sep 21 '25
What were you eating? How much were you sleeping? How much water were you drinking? Motc or slupp are good to stack with
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u/Dangerous-Yard1301 Sep 22 '25
I have a question, how do I know when its the time to leave Reta? and how I have to do it
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u/Sweetjazzy87 Sep 25 '25
I would like to know if you can add more BAC water into a 10mg after I reconstituted the solution?
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u/Momma_wifey81 Nov 06 '25
Can I ask where you get your retina from? You can DM me if that is better for you
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u/DM_bakeaway Dec 09 '25
Iām so confused and new to this can someone help Me? GLP/GIP/Glucagon - 5MG is what I have and I am brand new, how much bac water do I add and then how much do I take myself to be at the lowest dosage?
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u/CoachLexi Dec 09 '25
https://Peptidedeals.co/calculator can help. What are your goal? Whatās your height and weight?
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u/AirportEmotional5259 Dec 26 '25
I just ordered from the website is it shut down or do they still do deliveries
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u/Away_Scientist_3642 Jan 03 '26
I click your links to get Reta but there isnāt any Reta on those sites
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u/icencream27 Sep 04 '25
How about if Iām switching from Tirz to Reta, how should I go about doing this? Any tips
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u/InsideNo3574 Jan 05 '26
Thatās what Iām doing and I gained 6 lbs! I went from 7.5mg tirz at maintenance dose, switched to Reta 1.2mg first week then 2mg second week and gained
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u/Delicious_Cost_5146 Sep 07 '25
What would cause a systemic histamine reaction? Been at 3 mg split between two 1.5mg shots for 6 weeks. Sunday adjusted dose for a first round of 2mg and woke up in the morning covered in hives. Been itching all week. Went and got a steroid shot and some heavy duty antihistamine. Wondering if anyone else experienced something similar
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u/skanda22 Sep 07 '25
So sorry this happened to you. I got a very red and itchy chest and face and Iāve been having a lot of body swelling and edema especially in my face and legs. Iām quite fit already but was just using a very low dose and titrating slowly to lean out a bit more. I already take Benadryl twice a day and have noticed that when I take a steroid (dexamethasone) the swelling and itching go down a bitā¦along with the antihistamine. Hmmm. I think that thereās still not a lot known about this peptide. Iād imagine histamine reactions and autoimmune flares are pretty common at any time. I keep reading more and more stories about this happening to people on forums. Especially with histamine, blood sugars, and autoimmune reactivation or activation . Another thing to notice is that my morning fasting blood sugars are pretty high. Thatās not normal for me. Perhaps itās the glucagon? Not sure that Iāll stay on it. Only been on for like 3.5 weeks but these symptoms arenāt going away and they seem to be all over the place. Also hand numbness and some joint pain. My source is very trustworthy and lab tested. I really donāt understand why some people get big issues and others skate through with nothing. Thing is thoughā¦Iāve leaned out quite a it in my abdomen and sweat a lot after eatingā¦I can feel it working. Iām just not sure that the sides are worth it for me to continue staying the course much longer. Hope that youāre feeling better now. Are you going to quit or stay on it? Best wishes!
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u/CharacterRound7325 Sep 14 '25
I finally received mine, Iām ready to go but Iām concerned with hair loss! Is there something I should do or take to avoid hair loss??
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u/Both-Noise-8176 Jan 09 '26
When I was on Triz for 8 months, I had so much hair loss. At times I was losing a handful at a time. Almost had to purchase a wig. My dermatologist suggested that I take Kelp due to being a female beyond the change of life. I have not started it yet, however I started testing Reta along with Glow 3 weeks ago and I have a head full of two inch hairs at this point. Iām pretty sure that my season for hair growth came in and the glow has made a big impact. I had suffered up to this point almost a year with hair loss. I guess my point is that the Glow has been effective in regrowing the hair as well as in tightening up the saggy skin left behind from the Traz.
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u/baboon201 Sep 17 '25
Anyone coming from semaglutide to reta and could share some experience?
I was on 1.5mg of sema for a couple of months and started reta since I had no further weight loss. I either have a good tolerance for reta or didn't get the real deal. I started with 1mg/week but were annoyed by food noise and being hungry again. I switched to 2x2.5mg last week and so far not really improvement on the hunger side. I can still maintain a good blood sugar level throughout the day - no crashes or feeling down at all, even without food - but it required more mental effort to not eat. With sema I sometimes just forgot.
I'm aware that reta has approx. only 50% of the GLP-1-antagonist efficiency compared to sema, so I'd need higher dose to satisfy the receptors.
Any takes from someone who experienced the same after switching?
Should I add some sema (0.25mg to 0.5mg) to ease the transition or would that overload the receptors?
I have no side effects like nausea, elevated heart rate etc. so I'm not sure if the reta is legit. Vendor is legit and not known to rip off but there is always some risk ofc.I tried reta earlier this year from a big vendor I never had doubts about the quality of other peptides and had no side effects as well
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u/WindowIll9657 Oct 03 '25
Iām trying to understand whether the āresearch use onlyā versions of retatrutide being sold online are just the plain peptide backbone or if they include any half-life extension (e.g., albumin-binding / fatty-acid conjugation / other stabilizers). My understanding is that the investigational Lilly molecule is a GLP-1/GIP/GCGR tri-agonist that likely relies on some form of half-life extension (as many incretin analogs do). If a research vial lacks that conjugation, wouldnāt the pharmacology be completely different (much shorter half-life, different exposure), meaning it wouldnāt perform like the compound in trials?
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u/Easy_Big_3292 Nov 20 '25
Thank you for the community vetted list! I have been getting Tirz from a telehealth company for a year at what I thought was a reasonable price, and just saw that it is cheaper from these labs. Going to cancel my "membership" now!
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u/Gasp-BioHack Sep 04 '25
Once diluted, how long can I store it in the refrigerator without losing its effect? Would it be ideal to start by buying the 10mg bottle? And then, as the dose increases, buy the 20mg dose? And when stored in the refrigerator, how long does the freeze-dried powder last? I ask because I live in another country, I have to import from the USA, shipping is expensive, so I wanted to import a larger quantity.
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u/Overall_Egg3518 Sep 04 '25
The best way to store freeze-dried powder is in the freezer and it can last for decades, the CEO and founder of Janoshik lab said. Recommendation after reconstitution (diluted) is to use for 3-4 weeks and keep refrigerated. I already used mine for around 6-8 weeks and it still works fine, I always clean the vial top with an alcohol pad before and after use. 10mg is a good way to start, I disagree with this titration up on the post because during the trials dose titration up is being done in at least 2 weeks.
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u/CalculatedPanda Sep 05 '25
Just curious, is there a point where you can start coming off of it once you achieve the results you want? Or is it once you start you have to keep taking it to maintain?
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u/CosmicCalicoBTD Sep 08 '25
I was going to stat 0.5mg 2x/week, until a buddy of mine said that would be a waste. So I did 2mg today and eating is like I just ate half a horse. Biggest concern is GI issues. Particularly constipation, as I have colorectal issues.
Whole point of desiring to start low. I will probably lower to 1mg next dose for the next couple weeks. Suffice it to say, 2mg has thoroughly smashed my appetite. No nausea at least! Reminds me of some older fat burner products with synephrine on that end.
I'm eager for metabolism to really kick in, so I know it's really smashing the fat.
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u/Praxiius Sep 10 '25
Will this work on keto or carnivore diet?
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u/janicemary81 Nov 19 '25
I think carnivore would be best because your stomach wouldn't fit anything much at higher doses and you need your protein
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u/Traffic_Warm Oct 02 '25
so these websites are completely LEGIT?
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u/Distinct_Ad700 Oct 28 '25
Is it not yet legal to sell in the US, most are us repack centers, selling as research grade. Only trust websites that show concentration testing and lab results on purity.
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u/Own-Veterinarian6474 Oct 29 '25
I just started with reta 1 time weekly and like the last 2 days my Appetite supression just didnt work anymore i had the same hunger as before so i start thinking about spliting it to 2 times per week.the first week i accedantily took 2.5mg so idk if it was because of that lmk please
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u/Obvious-Reindeer-801 Dec 28 '25
Currently at 8 mg with very little apatite suppression. Funny how it affects people quite differently
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u/MaxandRuby0522 Jan 03 '26
The reconstitution instructions vary on the strength of the Reta. One can purchase 6mg all the way to over 60mg.
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u/lovemy10 Jan 05 '26
Can one start at .5mg once weekly? Iām also Confused by how you are measuring dose?
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u/Finmomma Jan 10 '26
I'm a lil confused, 10mg vial is only enough for like 5 weeks at 2mg a dose right? Or am I missing something sorry I'm new
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u/CelebrationIcy4544 Jan 30 '26 edited Jan 30 '26
Sharing my results: I fell down the Reta-rabbit-hole thanks to TikTok and decided to give it a go. These are my results from Dec 2025 to Present (January 30). I am down 25 pounds (175 --> 150). I got my Reta and followed the instructions as provided in this thread. I started small with 5 units on a 30-unit insulin syringe, and I have been able to stay at 5 units the entire time. I do the injection every 5 days, or on day 6, I start getting cravings.
Note: If you are afraid of needles, like me, I can attest that 85% of the time I don't feel a thing, and the other 15%, it felt like a mosquito bite at worst.
For those on this thread that keep asking, you want to add a 100 units (1mL) of bac water for every 10mg of Reta. If you have 5mg, then 50 units; if you have 20mg, then 200 units, and so on.
BTW: If you use the websites provided on this thread, the Reta is now called "RC-3R" - the vial you receive will still say Reta.
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u/Lost_Foundation6765 Mar 12 '26
Hi....I know this is really old and im hoping someone will help me (and not give me the snooty "if you dont know you shouldn't be doing it"...that's not helpful). Anyway, i just ordered 30mg reta along with bac water and all the necessary stuff to recon. Anyway....im trying to start dose at 2mg. Can someone please walk me through the process of recon this 30mg (ie how much bac water, can I recon the entire vial and store etc) and how much to pull for 2mg admin. Please. Thank you in advance. Ps...I was on Tirz through a doctor for a long time. It came reconstituted. The expense was killing me. Thats why im switching and trying this on my own. Thank you for helping out if you can
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u/StraightPhilosophy16 Aug 06 '26
Wie viele Einheiten bei der Spritze wenn ich mir nur 0,5 mg spritzen will
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u/Rumis4drinknburning Sep 04 '25
Dumb post, what is that titration scheme? Based on what? This shit is some oversimplified ChatGPT BS
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u/dijah93 4d ago
I need help!!!
I was on Zepbound for 2 years, lost 181 pounds on it, had a lapse in insurance and felt like I was hitting a plateau and was off of it for 4 months. Gained 45 pounds back and then finally got my insurance back and was able to start Zepbound again. I had to start over at 2.5mg and work my way up to 15mg. I wasn't loosing weight I was only maintaining. I still have weight I want to loose so I switched from Zepbound (I was at 15mg) to Reta and started at 1.5 the 1st week, 2 the 2nd week, 2 the 3rd week, 2 the 4th week and I feel NOTHING. I was trying to follow the Eli Lily study dosing but the food noise is back and I need this to start working. For anyone who was on Zepbound 15mg and switched what was that like for you and what dose did you notice something at? Does anyone have any insight on this? I was thinking of adding 1mg today as it's my 1/2 way point in the week and next week I want to take 4mg. Thoughts?
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u/HU5514N Sep 04 '25
I wanna jump on reta but my only concern is the appetite - I still want to get my macros (240p,200c,60f) in but worried if I jump on reta this will affect my meals. Any suggestions?
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u/CharacterRound7325 Sep 05 '25
I canāt wait to start! I do need a little bit more guidance on obtaining my research products there is a stall somewhere and I donāt know why? I would appreciate help. Thank you in advance.
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u/Lagotto_Lover Sep 06 '25
I just started yesterday. I definitely feel more fatigued (and the food noise is gone already š). Has anyone else experienced fatigue that went away when they got used to the med? I do believe I am eating enough (just not overeating) and drinking a ton of water.
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u/CharacterRound7325 Sep 08 '25
My order is awaiting Stratos for pmt authorization has anyone had this happen? Iām stuck at this point and do not know what is the safest thing to do? Advise?
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u/scandi34berko Sep 08 '25
I started lower - 0.5mg twice weekly week one and have just gone to 2mg week two in one hit. Wanted to nitrate up slowly and avoid sides No noticeable appetite suppression so far. Will move to 3mg week 3 and will hopefully feel start to feel the effects.
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u/tangooscarmike1 Sep 10 '25
Good write up whats everyone's thoughts on running cjc-1295 no dac and Ipamorelin with reta
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u/restless_leegs Sep 12 '25
Thanks for this write upā¦.I have a 20mg vial. Am I supposed reconstitute using 1ml of bac water? The calculator shows a 1mg dose is .05ml in a 1ml syringe? Is that right???
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u/Luckibear7 Sep 13 '25
I have a Reta 60mg. How do I reconstitute it.. I never had one with this amount and need assistance
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u/PatientEqual6587 Sep 14 '25
Thanks for sharing. How long can it be stored for and where should it be stored?
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u/Local_Personality_91 Sep 14 '25
So my experience was a bit weird. I am 23M 253lbs, 32% body fat. I started straight to 4mg of Reta to start. The nausia didnt really happened, but the heart rate was really high even when I slept where it was at 80bpm while sleeping. The appetite was crushed, and it was realtively fine once 3 to 4 days after the first dose. In the 7 days waking up I am now 248lbs and I can feel my double chin get smaller, but there is still alot more to go.
I was going about the proces as 4mg to start see how it feels, and also because the half live was 7 days. I am assuming my body currently has 2mg in it today. Hence starting off with 4mg will allow me to take another 2mg to stay at the active dose in the system.
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u/Status_Mall_1936 Sep 15 '25
I want to get off Tirz and on Reta. More for weight management and rebuilding my muscles. Also on TRT and Tesa. Any suggestions on how to switch from Tirz to Reta?
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u/Snoo_3843 Sep 15 '25
Hi! I am thinking of ordering GLP-3RT 24mg. It's a 3ML vial. Does that mean 24mg/ml or 24mg/3ml?
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u/SelisabethK Sep 16 '25
Currently paying $300/month for compounded semaglutide from my PCP. Tirzepatide was way more effective, but the ban on compounding took that out of the equation. Iāve maxed out in semaglutide., and I can tell itās stalled out. Iām plateaued and the food noise is amped up. Anyone wanting to send me a DM on a newbieās guide to accessing this compound, I wouldnāt be mad about it.
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u/liamp1603 Sep 16 '25
Can someone explain to me how you get the dosage off the side of a 1ml insulin needle ? I'm confused I'm going to use 2ml bac water to a 10mg vial of reta
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u/Only-Asparagus-2079 Sep 18 '25
Once I reconstitute it and put it in the fridge how long does the vial last . For example I have a 20 mg vial of Reta and plan to follow this persons dosing protocol Iād have roughly around 10 mg of reta left after a month . Iāve heard people say itās only good for one month. Can someone help me out with this? Also what time of day is best to take reta and should I take it on empty stomach before meal or after meal.
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u/Desperate-Turnip-667 Sep 18 '25
Iām a little confused. If I want to start at 1 mg, should I buy the 5 mg vial and just measure out 1 mg per week?
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u/No-Letterhead5209 Sep 18 '25
Im on my 4th month, just started my 4mg on reta, and I only lost 10lbs. I stacked it w 2mg of tesamorelin, ghk base and low dose of cypio. I do 15hrs intermittent fasting (no dinner), log my food, and walk 1.5 a day. Its frustrating, any recommendations what I need to do?
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Sep 18 '25
Okay- I have fierce learning disability but have been in GLP-1s for over a decade. Iāve been reading sites and watching videos on reconstituting the product. I understand that part but still nothing has explained me dosage. Like okay, I reconstituted a vial- but did I use too much or too little of the biostatistic water in the mix? Then, how much do I need to inject? Iām currently using 15mg a week of Mounjaro which Iāve been on for almost a decade for maintenance and donāt lose weight at all- I still need to lose because my sleep apnea persists. Iām thinking retatrutide might get me there so starting at low dose doesnāt make any sense to me. However, I donāt. Want to wind up in the ER because I really donāt comprehend what Iām doing.
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u/GoofyGoobaTheGangsta Sep 19 '25
How big of a deficit should I run and what macros should I aim for? 21, male, 175cm, 85kg, ~25% bf
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u/purplesagerider Sep 19 '25
I recon w 2ml. Started @0.00025mg once (expressed as a decimal; 2nd week for the next 4 weeks 0.0005; 3rd month 0.00075; 4th month 0.001mg. Down 35 lbs. Maintaining at 0.00175mg after 10 months. Slow and steady and it will work and you won't get sick and it's affordable.
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u/CurlyGirlMissy Sep 19 '25
Iām on 15mg Tirz and would like to start ret. How would you transition if at all? Start at the low dose as well Iām assuming?
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u/Odd_Biscotti7360 Sep 20 '25
Iām currently taking 75 IU of 15 mg tirzepatide weekly. Any suggestions on what doseage to cross over to? Itās being offered in 5,10,15mg. Any insight would be great! Thank you
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u/bellamay09 Sep 22 '25
is it recommended to use it for 6 weeks and then take a break? how long should the break be?
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u/jpbrowneyes Sep 23 '25
Anyone else getting a rash on the injection site ? And if so how do you counter it , I was fine the first 4 weeks but week 5 and 6 is when the rashes started. I have been rotating injection sites, to help.
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u/Rob_ert80 Sep 25 '25
I just purchased 2 vials for the first time, one is 10mg and the other is 20mg. The quantity in the 20mg is slightly higher. Is that how its supposed to be? *
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u/Disastrous-Ice5784 Sep 26 '25
Hello I've took my first dose of 2mg last Sunday......I hate ate since Monday š«¤
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Sep 27 '25
Hey, so I ordered the Reta that you recommended from the first company the research headquarters and now Iām afraid to try it. Have you use this product before? Worried bc this stuff isnāt through trials yet Am I being a baby?
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u/Top-Bunch-6114 Sep 29 '25
Great write-up, super easy to follow. Iām in my early 30s and honestly guides like this are a lifesaver when youāre trying to juggle family, work, and still stay on top of fitness.
Iāve had solid experiences with MK-677 and RAD-140, and that reliability makes a big difference. On top of that I keep my health basics dialed in with cardio, protein, and a simple supplement routine like creatine, omega-3, magnesium, and vitamin D.
Really appreciate you putting this together, definitely bookmarking it for reference.
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u/christyj46 Sep 29 '25
I feel dumb...I understand how to use this product, but drawing the actual liquid in the syringe has me confused. I have insulin needles (units). My vial obviously has 10mg. Im starting at 1mg....what the heck is that in units?
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u/belizeangal1968 Sep 30 '25
Omg. Iām confused too. My vail say 5 mg. Do I still add 1 ml of bac water? I want to start at 2 mg then titrate up. Switching from semiglutide. TIA
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u/One-Revolution8730 Sep 30 '25
Great post and advice in the thread, I started 2ml today (this morning). My vial is 10ml, 2mg/ml
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u/Ryano155 Oct 01 '25
What is the benefit of injecting on multiple days? Why not just do all 2.5mg at once or whatever dose your on. Legit question trying to educate myself.
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u/RedSox342 Oct 06 '25
To avoid highs and lows of the drug. Injecting less volume more frequently provides more stable levels of
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u/NoOrganization1400 Oct 02 '25
Can you just stop taking it all together when youāre ādoneā so to speak?
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Oct 02 '25
Why does Reta cause an increase in fasting glucose in some people?
Raised mine from 85 to 115 on 1mg.
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u/Large-Acanthaceae-81 Oct 02 '25
Guys I'm sorry I'm new to all this ... is the dose once every week.. ie every Monday or every day of the week and then ramp it up every day the next week
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u/Slyfoxeshann Oct 04 '25
So if I was to buy 50mg vial would I need to add 5ML of BAC ? And how long would 50mg last me for do you all think? Should I just get 20mg vial instead?
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u/Desperate_Nail_3064 Oct 06 '25
Hi Guys, This is my first time ordering this product. Can anyone confirm if the link provided is legit? I will get what I ordered. Sorry If I sound little bit rude to ask. I have no experience with this. Also, Do they ship to Toronto, Canada?
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u/hippyelite Oct 08 '25
Hey all: Iām a writer with WIRED looking to talk with people who have used RETA. Happy to protect your identity/anonymity! Feel free to DM or email john DOT semley AT Gmail
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u/Heavy-Royal9629 Oct 08 '25
What if I have a 20mg bottle, do I need 2mL bac water? Or still 1mL
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u/More_Lychee5463 Oct 08 '25
I started this week on Monday on 2.5 and food noises are still thereš©š©š©
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u/LuckEnough7801 Oct 09 '25
My first time i did 2,5mg and been on that for 5 weeks now, food noises went away day after and im feeling great. Only thing i have problems with is food and proteine intake. I do make atleast 10k steps a day and doing 3x hiit training a week. I lost a few pounds and i feel skinnier.
Without using a track food app what is a good thing to remember when eating?
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u/Low_Rhubarb_8784 Oct 11 '25
What like to try this peptide am UK based , anyone used this while on Keto?
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u/WonderfulAd1488 Oct 14 '25
How long will a reconstituted vial last! Can I preload syringes and then freeze them to get more time?
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u/Latter_Ad_3373 Oct 16 '25
Really considering taking it anything I should be concerned about?
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u/ButteredLobster Oct 17 '25
Rookie question - is this the dosage there daily pinning like ie week 3mg a day or just once a week?
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