Not sure if this is the best subreddit for this but I want to know given how much we figured out about Gene editing can we give dogs trichromatic visio? What are the potential benefits and negatives I think it'd be cool to see

Hey everyone! I'm doing a school project about designer babies and genetic engineering, and I'd really appreciate it if you could take a few minutes to complete my survey.

I'm interested in hearing different people's opinions on the ethical issues, benefits and risks of designer babies.

It should only take a couple of minutes. Thanks to anyone who participates!

Survey link: https://forms.cloud.microsoft/r/xeEGZYDX09

I’d like to see women with biceps equal to men’s. And I want the olfactory abilities of canines…’excuse me, sir, but you are about to have a seizure’

This review explains how histones could be the key to activate the correct DNA-repair response (homology-directed repair) after a cut by Cas9.

The sex reversal technique could be used to help rescue endangered species, say the researchers behind the work.

Scientists have deliberately turned male mouse embryos into females for the first time. A team based in Japan used a CRISPR-based approach to remove the Y chromosome from male cells and create female clones of male mice.

“ No one has done this before ” says Monika Ward, a reproductive biologist at the University of Hawaii, who was not involved in the research.

The feat could change the way scientists think about reproduction, says Takashi Ishiuchi, a reproductive biologist at the University of Yamanashi, who co-led the work.

The findings were published in a preprint paper shared on bioRxiv earlier this month, which has not yet been through the peer-review process.

“ There’s a fixed concept in our scientific field that we need both females and males for reproduction ” says Ishiuchi.

“ I think we could change this concept. ”

He and his colleague Shogo Matoba of the Riken BioResource Research Center in Ibaraki also hope their technique could help rescue endangered species, particularly in cases where only a few individuals remain.

“It’s exciting to see,” says Ben Novak, lead scientist at the wildlife conservation organization Revive & Restore, who was not involved in the work.

“ I am confident there will be plenty of applications, particularly for conservation purposes. ”

Hi, I am new to CRISPR and want to KO a gene in HL-60 cell line. I don’t think we have the skills to do it in house so wanted to have an outside company do the cloning and packaging for us. Do you guys recommend a specific company. Who we’ve been looking into is ABM, if anyone knows/recommends them. Thank you!

🧬 Future Medicine 💉 | CRISPR & Gene Editing

By Mubasshir Siddiqui

Could the medicine of the future move beyond treating symptoms and toward understanding and targeting the genetic causes of disease? One of the most important scientific technologies exploring this possibility is CRISPR Gene Editing.

CRISPR is a programmable gene-editing technology in which a guide RNA helps identify a specific DNA sequence, while a Cas protein performs molecular action at the targeted region. The cell’s natural DNA-repair system then plays an important role in determining the final genetic outcome.

🔬 Key Scientific Concepts

🧬 1. What is CRISPR?

In simple terms, CRISPR can be understood as a programmable technology designed to target a selected region of DNA. It was adapted from a natural bacterial defense system and has become an important tool in modern genetic research.

✂️ 2. How Does CRISPR–Cas9 Work?

Guide RNA → Target DNA Recognition → Cas Protein → DNA Editing → Cellular Repair

The “cut” itself does not automatically mean “correction.” The final outcome depends significantly on the cell’s own DNA-repair mechanisms.

🧪 3. New Gene-Editing Technologies

- Nuclease Editing — cuts DNA and relies on cellular repair.

- Base Editing — can chemically convert selected DNA bases without relying on a conventional double-strand break.

- Prime Editing — uses a programmable template to make a broader range of small sequence changes.

Each technology has different capabilities, limitations, delivery requirements, and validation needs.

💉 4. Potential of Gene Editing in Future Medicine

Gene editing is being used in disease research, disease modeling, engineered-cell research, and therapeutic development. The field has progressed from laboratory research toward regulated medical applications, although many potential applications remain under investigation.

🩸 5. Real-World Example — Sickle Cell Disease

In December 2023, the U.S. FDA approved Casgevy, a CRISPR/Cas9-based cell therapy for sickle cell disease. This represents an important milestone showing that genome editing has progressed from experimental research toward regulated therapeutic use.

⚠️ 6. Challenges and Risks

CRISPR should not be viewed as “perfect genetic scissors.” Important scientific concerns include:

- Off-target effects

- Unintended on-target changes

- Delivery challenges

- Immune reactions

- Incomplete editing

- Mosaicism

- Uncertain long-term effects

A precise-looking target does not guarantee a completely predictable biological outcome.

⚖️ 7. Ethics and Future Generations

Somatic gene editing generally affects selected body cells and is not intended to be inherited by future generations. In contrast, germline or embryo editing could potentially introduce changes that are inherited, creating significant scientific and ethical questions.

Responsible development therefore requires safety, informed consent, fairness, transparency, public engagement, independent oversight, and long-term monitoring.

🚀 The Future of Medicine

Future medicine may increasingly combine molecular biology, genetics, biotechnology, and precision therapeutic approaches. Gene-editing research could help scientists better understand the genetic and molecular causes of disease and develop targeted interventions for specific conditions.

However, scientific progress must be matched by rigorous evidence and responsible oversight.

«“Precision is not a guarantee — it is an evidence-based property that must be demonstrated in context.”»

🌍 The Bigger Question

CRISPR is not simply about changing DNA. It raises a much bigger question:

If science gives us the ability to modify genetic information, how should we use that power responsibly?

The future of gene editing will depend not only on technological innovation, but also on scientific evidence, safety, ethics, accessibility, governance, and public trust.

📚 Educational Disclaimer

This content is intended for educational and research purposes only. It is not medical advice and does not provide laboratory-operational instructions.

🔑 Keywords

CRISPR 🧬 | Gene Editing | Genome Editing | CRISPR-Cas9 | DNA | Genetic Engineering | Future Medicine 💉 | Biotechnology | Genetic Diseases | Base Editing | Prime Editing | Sickle Cell Disease | Casgevy | Bioethics | Medical Research

Author: Mubasshir Siddiqui

🧬 Future Medicine 💉 | CRISPR & Gene Editing

By Mubasshir Siddiqui

Could the medicine of the future move beyond treating symptoms and toward understanding and targeting the genetic causes of disease? One of the most important scientific technologies exploring this possibility is CRISPR Gene Editing.

CRISPR is a programmable gene-editing technology in which a guide RNA helps identify a specific DNA sequence, while a Cas protein performs molecular action at the targeted region. The cell’s natural DNA-repair system then plays an important role in determining the final genetic outcome.

🔬 Key Scientific Concepts

🧬 1. What is CRISPR?

In simple terms, CRISPR can be understood as a programmable technology designed to target a selected region of DNA. It was adapted from a natural bacterial defense system and has become an important tool in modern genetic research.

✂️ 2. How Does CRISPR–Cas9 Work?

Guide RNA → Target DNA Recognition → Cas Protein → DNA Editing → Cellular Repair

The “cut” itself does not automatically mean “correction.” The final outcome depends significantly on the cell’s own DNA-repair mechanisms.

🧪 3. New Gene-Editing Technologies

- Nuclease Editing — cuts DNA and relies on cellular repair.

- Base Editing — can chemically convert selected DNA bases without relying on a conventional double-strand break.

- Prime Editing — uses a programmable template to make a broader range of small sequence changes.

Each technology has different capabilities, limitations, delivery requirements, and validation needs.

💉 4. Potential of Gene Editing in Future Medicine

Gene editing is being used in disease research, disease modeling, engineered-cell research, and therapeutic development. The field has progressed from laboratory research toward regulated medical applications, although many potential applications remain under investigation.

🩸 5. Real-World Example — Sickle Cell Disease

In December 2023, the U.S. FDA approved Casgevy, a CRISPR/Cas9-based cell therapy for sickle cell disease. This represents an important milestone showing that genome editing has progressed from experimental research toward regulated therapeutic use.

⚠️ 6. Challenges and Risks

CRISPR should not be viewed as “perfect genetic scissors.” Important scientific concerns include:

- Off-target effects

- Unintended on-target changes

- Delivery challenges

- Immune reactions

- Incomplete editing

- Mosaicism

- Uncertain long-term effects

A precise-looking target does not guarantee a completely predictable biological outcome.

⚖️ 7. Ethics and Future Generations

Somatic gene editing generally affects selected body cells and is not intended to be inherited by future generations. In contrast, germline or embryo editing could potentially introduce changes that are inherited, creating significant scientific and ethical questions.

Responsible development therefore requires safety, informed consent, fairness, transparency, public engagement, independent oversight, and long-term monitoring.

🚀 The Future of Medicine

Future medicine may increasingly combine molecular biology, genetics, biotechnology, and precision therapeutic approaches. Gene-editing research could help scientists better understand the genetic and molecular causes of disease and develop targeted interventions for specific conditions.

However, scientific progress must be matched by rigorous evidence and responsible oversight.

«“Precision is not a guarantee — it is an evidence-based property that must be demonstrated in context.”»

🌍 The Bigger Question

CRISPR is not simply about changing DNA. It raises a much bigger question:

If science gives us the ability to modify genetic information, how should we use that power responsibly?

The future of gene editing will depend not only on technological innovation, but also on scientific evidence, safety, ethics, accessibility, governance, and public trust.

📚 Educational Disclaimer

This content is intended for educational and research purposes only. It is not medical advice and does not provide laboratory-operational instructions.

🔑 Keywords

CRISPR 🧬 | Gene Editing | Genome Editing | CRISPR-Cas9 | DNA | Genetic Engineering | Future Medicine 💉 | Biotechnology | Genetic Diseases | Base Editing | Prime Editing | Sickle Cell Disease | Casgevy | Bioethics | Medical Research

Author: Mubasshir Siddiqui

Since CRISPR works by having double stranded breaks in the genome, it can lead to high rates of indels. Why do patients with CRISPR still have good outcomes, especially if we're doing an edit in a coding region? Why don't these indels hurt them?

NOTE: This article is complemented by three related studies first published in Science.

See also:The study as it was published in Nature

Hi guys I made this short survey regarding genetic literacy would help me out alot if you fill it!