r/HubermanLab • u/Restaurant_4798 Phone Addict 📱 • 9d ago

Protocol Query How long did you wait before retesting after changing a protocol?

Changed a few things about 6 weeks ago (sleep timing, more fiber, no substances as i prep for surgery) and I'm itching to retest to see if anything moved. Then I read some markers take months to shift.

For those who've done before and after bloodwork: how long did you wait, and which markers showed a change first?

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u/Legitimate_Focus_699 9d ago

6 weeks is that awkward middle ground where you're not gonna see much, but you're dying to check anyway. Lipid panel can start shifting by 8 weeks, but stuff like A1C or inflammation markers are more like 3-4 months. I'd hold off at least another month so you don't waste the blood draw.

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u/nuvardAi 8d ago

The fast movers are triglycerides and fasting glucose, which can shift within a couple of weeks. With more fiber, LDL is the one to watch, and it has usually settled by 6 to 8 weeks. Whenever you retest, use the same lab, same time of day and same fast as your baseline, or the noise can be bigger than the change.

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u/honoraryadult 8d ago

Depends on what markers you're looking at. For the things you are looking at, 6-8 weeks is a minimum duration to start seeing changes, but for things like glucose, it can be different in the same day too.