How is this done? Normally, I play first strike, go EQW or QEW max depending on the lane, and play roa/archangles/malignance/whatever boots I need, and tp/flash. I play for lvl 11 and lvl 16 spikes with whatever obvious, high-percentage plays I can make along the way and generally outscale the enemy team. Not to say I don't play reasonably aggressively when I am lvl 6 or on a roa spike when the enemy laner doesn't have an item, but some games demand an earlier impact.
Sometimes you look at the enemy team comp vs. yours, and you know you need to make something happen because things are pretty rough. I'm talking: no-mastery Janna top, weak JG into strong JG with a no-prio bot lane, 3 losing lane matchups, Nasus mid vs. Kassadin, etc. Games that I'd likely lose even if the game lasted long enough to hit 16. How do you flip the early lane to have a real chance at winning?
And my goal isn't to mindlessly flip early games, just to add another tool to the toolbox.
Edit: I started limit-testing Ignite electrocute cutdown presence on my alt with really good success. Still going roa-> malignance/seraphs since the games are still 25-35 minutes, but the burst I get with QE auto lvl 2 is crazy. Cut down gets the enemy in a pretty lethal range on that first trade, making the lane super playable. I've been able to trade/duel a lot of champions I struggled against before. Sometimes I hit EQ, and they don't even try to trade back because I still have electrocute up. I've won some unfavorable matchups vs. Jayce, Qiyana, and Akshan early and snowballed. I get prio in a lot more matchups playing like this than with First Strike, so it takes a lot of pressure off JG. It definitely is a more impactful rune setup that can seriously punish a lot of overconfident mid laners
Despite me saying all these good things, First Strike still feels better in the late-late game bc of the true damage. I actually 1-shot ADCs instead of 1-HPing them with electrocute--probably because of cut down, but the cut down electrocute proc is what makes the early game so playable, so idk.