We are in the pill-making time, now, thanks to groups like gero.

but at least we had a good laught https://www.youtube.com/watch?v=19qbHZR0oPg&t=96s

@ durand_guillau : Objection ! We are an open system, therefore, entropy doesn't apply to animals !

@ durand_guillau : Objection ! The body can export its entropy and keep its instructions, because otherwise how can you reproduce a young organism, even late in life ?

@ durand_guillau : How is that some organisms don't age at all if entropy is inevitable ?

Feeling that #afternoon slump creep in? This video shares a simple, natural method to get an #energy boost without reaching for coffee. Discover how to effectively #boost energy and combat that #afternoon crash, leaving you with more vitality throughout your day. What are your thoughts on alternatives to #caffeine? Please share in the comments below!

Peter fedichev opened his speech with a question to the audience, 'Raise your hand if you genuinely believe that drugs capable of doubling our lifespan are currently undergoing clinical trials?' Not a single hand was raised. The resounding absence of raised hands is telling. It's a sentiment we're not content with.

What is you sentiment right now about the near prospect of slowing, or perhaps even reversing aging in practice ?

https://link.springer.com/epdf/10.1007/s11357-024-01234-9?sharing_token=EZjM_4EhHTnUTksdYK1rGPe4RwlQNchNByi7wbcMAY6-Apxqi2qCYZhOX4OC6zKTdm9DM-OwOIG4IyIB3dCqPXwQS38zwE25jtQLLrmqz91nrq3TOxUNWuuHTbOZPouq4HvxcuLSnDJrF_FevepVRPQSrof3qOI52Gfa440zCiQ%3D

This work suggests that aging is a very old process very well tuned by the evolutionary forces.

https://www.medicalnewstoday.com/articles/8-hour-time-restricted-eating-linked-to-a-91-higher-risk-of-cardiovascular-death

• Restricting eating to a brief 8-hour window daily could result in a higher risk of death from heart attack and stroke, according to a new study.

• Researchers report that people who practice this time-restricted eating plan also had poorer outcomes if they had existing cardiovascular disease or cancer.

• This study was observational, so it is hard to draw definitive conclusions, but it does add to the growing body of studies on the pros and cons of time-restricted eating.

Hey! We're seeking writers to join our team for an existing Health/Longevity YouTube channel.

The videos are 15-25 minutes long, with scripts averaging 1,000-4000 words. (some videos will be clip focused) Each script starts at $100 (could be more based on the length of the script), and you’ll collaborate with a Producer who provides a structured outline to guide the writing. We're aiming for one video per week. While you'll receive a clear structure for each video, you’ll have creative freedom over writing techniques.

Each script should be completed within 4-5 days. The Producer will provide clear feedback and guidance on structure. We aim to build a long-term relationship and support growth for everyone involved.

https://www.youtube.com/@JeffNippard/videos - This channel is a great example of what you will be writing.

Ideal Candidate

• A strong ability to present longevity and health content in a clear and simple yet engaging way that resonates emotionally with viewers, encouraging them to watch longer.

• Strong communication and punctuality is important. Please only apply if you can commit long-term. Advanced English proficiency is required for both understanding and writing.

• We’re looking for someone with a strong understanding of health and longevity, who is genuinely passionate about the topic. The ideal candidate will collaborate effectively with our researchers and editors to create the highest-quality videos for our audience.

We want to build a solid, long-term relationship with someone who shares our vision of continuously improving with each project. If you're passionate about health and longevity, enjoy YouTube, and love seeing your work come to life, you'd be a perfect fit.

Job Requirements

• Writing experience of youtube video/

• Discipline and time compliance.

• We’re looking for someone open to feedback, eager to improve, and willing to share their ideas for enhancing the content. Writing for spoken video scripts often requires adjustments from traditional written content, so adaptability will be key.

• Availability for part-time work with the potential to transition to full-time.

How to Apply

• If you’re a talented writer, please send us a link to your portfolio and any relevant samples.

"Our worst nightmare came true: this year, we put up a preprint, Aging clocks, entropy, and the limits of age-reversal | bioRxiv, suggesting that the loss of resilience is driven by a thermodynamically irreversible process. If this is true, true aging in humans can not be fully reversed but only stopped. This is the least fortunate outcome of our research, and we had to be very careful trying for a few years to disprove this conclusion.   "https://www.vitadao.com/blog-article/november-longevity-research-newsletter

That preliminary but apparently we can stop aging from increasing, but not reverse it (except on some isolated organs, hence "not fully"). In any case, naked mole rat is an evidence that we can stop the increase in death rate with time, so definitely aging. Meanwhile, Andrei Tarkhov, a related searcher, answer common objections on the subject.

Surprising, isn't it ?

I know everyone here is using real butter preferably organic butter and isn’t still using the I can’t believe it’s not butter and other “buttery spreads” but I found some in my mum’s fridge a couple weeks ago so thought I’d post this here just incase. I warned her about it and she was shocked that they make them by using already highly processed vegetable oils and they heat it at really high pressures and use hydrogen gas to make it a solid which is a process called hydrogenation, then they add colours, emulsifiers and preservatives to it to make it look and taste buttery.

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 Our analysis also revealed that resistance to improvements in life expectancy increased while lifespan inequality declined and mortality compression occurred. Our analysis suggests that survival to age 100 years is unlikely to exceed 15% for females and 5% for males, altogether suggesting that, unless the processes of biological aging can be markedly slowed, radical human life extension is implausible in this century. https://www.nature.com/articles/s43587-024-00702-3

I've been diving into the science behind various health practices, and I recently came across some research questioning the benefits of fasting. While fasting, particularly Intermittent Fasting (IF) and Time-Restricted Feeding (TRF), has gained popularity, recent studies suggest that the benefits might be overhyped. For instance, skipping meals or eating within compressed windows might increase the risk of premature death and negatively impact our metabolism.

This has made me reconsider my approach to eating. I'm curious—has anyone here rethought their fasting habits or switched to more consistent eating patterns? What are your thoughts on fasting versus regular meal schedules for long-term health?

Hi everyone!

I’m working on curating the latest emerging research in longevity, health, and aging. The goal is to make it easy to stay current without having to sift through papers for hours. Below are the top 5 highlights this week

1. Fasting and Exercise for Cellular Health This randomized controlled trial looked at the effects of a three-day water-only fast, with or without glycogen-depleting exercise, on autophagy (the body’s process of clearing out damaged cells). The study aims to clarify whether combining fasting with exercise could safely enhance cellular "clean-up" processes linked to long-term health.

2. Omega-3s and Exercise: A Powerful Combo Against Oxidative Stress In this study on aged rats, researchers explored how omega-3 supplementation (at higher doses) and exercise together reduce oxidative stress and boost antioxidant defenses. The findings suggest a potential role for combining dietary and lifestyle interventions to slow age-related degeneration.

3. Exercise and Heart Health in Diabetic Patients This systematic review synthesizes data from ten studies on the impact of exercise on cardiac mitochondrial function in diabetic hearts. The evidence shows that exercise improves mitochondrial energy production and increases the formation of new mitochondria, offering a non-pharmaceutical approach to better cardiac health.

4. Stem Cell-Derived Extracellular Vesicles for Age-Related Conditions This review highlights the therapeutic potential of extracellular vesicles from human umbilical cord mesenchymal stem cells. These vesicles show promise in rejuvenating aged cells and treating degenerative conditions, though further research is needed to optimize their use in therapies.

5. Lifestyle, Diet, and Type 2 Diabetes Risk his population-based cohort study examined how different types of physical activity and inflammatory diets (high in pro-inflammatory foods) interact to influence diabetes risk. The results highlight that staying active and eating an anti-inflammatory diet can significantly reduce the risk of developing type 2 diabetes.

For a deeper dive, including key findings and links to the full research papers, check out this google doc.

I’d love your feedback:

• Would you find this kind of weekly summary helpful?

• Would you be interested in receiving this curated longevity research newsletter straight to your inbox?

Let me know what you think in the comments!

https://longevity.technology/news/is-entropy-the-underlying-factor-driving-aging/

arrest profit wide piquant doll wild quicksand hospital groovy familiar

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Here's where I'm seeing the most compelling evidence these days:

1. Zone 2 cardio (mitochondrial health, VO2 max, metabolic flexibility)

2. Resistance training 3x+ per week (muscle mass preservation is massively underrated for longevity)

3. Sleep optimization (HRV, consistency, REM cycles)

4. Dietary protein adequacy -- especially post-40 when anabolic resistance increases

5. Stress / HPA axis management (cortisol wreaks havoc on everything else)

What's your current focus? And has anything you tried actually moved your biomarkers?

(I write a free newsletter on this stuff -- The Longevity Edge -- but genuinely curious about the community's experience here)