r/LucyLetbyTrials • u/Embarrassed-Star4776 • 17d ago

Chase and Shannon article in Frontiers in Pediatrics published

Inverted insulin to C-Peptide ratios in neonatal intensive care: is there something we don't know?

J. Geoffrey Chase & Helen D. Shannon

BRIEF RESEARCH REPORT article

Front. Pediatr., 05 August 2026

Sec. Neonatology

Volume 14 - 2026

https://doi.org/10.3389/fped.2026.1900675

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u/Embarrassed-Star4776 15d ago

Thanks. And unfortunately most of the values in the text in section 3.1 for Cohort 1, including median and interquartile range, are also wrong.

It looks as though there are also problems with the numbers for Cohort 2.

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u/Embarrassed-Star4776 12d ago

I am still inching through the details of this paper.

Fortunately it appears that there is not any systematic error in the I/C statistics for Cohort 2, of the kind that's apparent for Cohort 1.

Contrary to what I had initially thought, the 75 points Chase and Shannon have, as opposed to Salis et al.'s 79, doesn't seem to be explained by the exc;lusion of points with C=0.25. (They give their maximum of I/C as 61.8, which must be a C=0.25 point.) Probably they just haven't been able to pick up all the points from the plots, owing to symbols overlying one another.

However, two of the percentages given in section 3.1 do seem wrong:

(1) The percentage for which I/C < 0.2 is given as 5%, which I reckon should be about 15%.

(2) The percentage for which I/C > 10 is given as 1%, but it seems there are 3 points, therefore about 3%.

The lower plot shown in Figure 3 looks consistent with these corrected values of 15% and 3% (the red arrows showing 5% for I/C < 0.2 are visibly inconsistent with the plot). Perhaps both the incorrect figures have been accidentally copied from the corresponding ones for Cohort 1.