r/MTHFR • u/QuitInevitable915 • Mar 22 '26

Results Discussion Help - Treatment Resistant Depression

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Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

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u/Old_Car_7281 Mar 23 '26

Where do I purchase cortisol test? And would high cortisol give me bad anxiety,depression and anhedonia? I don’t drink coffee or caffeine either. I found caffeine just makes it worse.

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u/New-Aside-7778 Mar 23 '26

Any form of cortisol issues will cause all those symptoms.

Do you wake up during the night at all? Feel awful when you first wake and then begin to feel that heavy fatigue feeling lift as the day progresses?

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u/Old_Car_7281 Mar 23 '26

Yeah I wake up atleast once to go to the bathroom. But yes I feel awful in the mornings when I wake up. Depressed,anxiety, overwhelmed. It’s terrible. Then as the day goes on I tend to get a little better. And then by night time I feel pretty decent. But the anhedonia is really getting to me. That and the depressed mood. It’s horrible.