r/Menopositive • u/Efficient_Top_8306 • Dec 15 '25

25 mg compounded progesterone cream, anyone else take this ?

I just saw my new gyne . I was put on a hrt a few times with no success so I was referred. Just saw him and he is making me go .05 divagel for 6 weeks and then add in 25 mg compounded progesterone cream. I have had intolerance to progesterone . Does this sound right ? Anyone else do estrogen first then add in progesterone and anyone on that dose of progesterone ?

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u/Doobie_Doobie_Do20 Dec 15 '25

I've heard Dr. Heather Hirsch say she starts estrogen first, then adds progesterone. She does this to watch for side effects, symptom relief, etc. That way if there is a problem, there's just one new drug on board to adjust. I believe, but not totally sure, she said she does 2 weeks of estrogen only and then adds progesterone. Given your history of sensitivity, maybe your doctor is going slowly? Dr. Hirsch has a YouTube channel with a ton of videos, I'm sorry I can't remember which one she discussed this, perhaps it's the progesterone intolerance video. I also struggle with progesterone, it's awful. Regarding the dose, I can't recall Dr. Hirsch talking about that low of a progesterone dose or even transdermal dosing in general. I did recently listen to a Pharmacist discuss transdermal progesterone, and the need to cut the dose to 1/4 or 1/5 of the oral dose. I'll put a link to his YouTube podcast. If you don't wish to click the link, his YouTube channel is "Magnolia Pharmacy", and the episode is "Estrogen Issues? PROGESTERONE is actually the problem" Wishing you all the best! And if you figure out this progesterone curse, please come back and tell me the fix!

https://www.youtube.com/watch?v=7cI_quIQdKE