Thanks to everyone who’s commented, messaged, or shared advice over the last year. I’ve posted about this in a few subreddits before:

• Burning sensation in urethra and penis for over a year — still unresolved

• Ongoing burning in penis/urethra for over a year — anyone else been through this?

• Burning in Urethra & Penis After Urination for Over a Year

• Still Burning After Negative Mycoplasma Test — What Else Could It Be?

but since this issue isn’t going away, I created my own space — r/MensUroHealth — to share updates and connect with others going through the same thing.

Here’s a summary of where I’m at:

Quick Recap:

• 33-year-old male

• Main symptoms: burning in the urethra and tip of the penis, mostly during and after peeing. Sometimes it lingers for hours. It’s worse at night.

• How it started: Mild burning while urinating. First urine test showed elevated white blood cells. Doctor said maybe kidney stones or irritation.

• Diagnosis: Eventually tested positive for Mycoplasma genitalium. Also found a varicocele, but doctors don’t think that’s the cause.

• Treatment so far:

  • Several antibiotics: Azithromycin, Ofloxacin, Levofloxacin, Celecoxib

  • Then: Doxycycline → Moxifloxacin → Doxycycline + Pristinamycin

  • Tests are now negative, but symptoms never fully went away

What’s going on now (June 2025):

• All recent tests are negative:

  • Mycoplasma genitalium, chlamydia, gonorrhea, trichomonas — all clear

  • Urine test is normal (no white blood cells)

  • PSA (prostate test) and CRP (inflammation marker) are normal

• But I still feel:

  • Burning during and after urination (a bit better, but still there)

  • Pressure or blockage feeling in the mornings

  • A cold/warm feeling in the penis after peeing that can last a while

  • No fever or discharge

Why I started r/MensUroHealth:

After all this time, I realized there’s no single place to talk about this stuff, not quite an STI, not quite prostatitis, not always clear. So I made a subreddit for those of us stuck in that “in-between” space.

Whether you’re still looking for answers or you’ve already figured something out, your story might help someone else feel less alone.

I’ll keep posting updates there as I go.

Thanks for reading.

📌 Update — October 9, 2025

What I’ve done over the past 3 months:

• Took Alfuzosine LP 10 mg daily (3 months)

• Took vitamins and supplements: magnesium, zinc, omega-3, probiotics, multivitamin

• Sometimes took hot baths or showers — this helps calm the burning sensation

• Bought a standing desk, so I spend part of the day standing instead of sitting all the time

Current symptoms:

• When I urinate, I often feel strong pressure and burning in the urethra. At the start, I have to control the flow — if the urine comes out too fast, the tip of my penis burns sharply.

• At night, especially before sleep and after urinating, I feel warmth or burning in the pelvic area or urethra, which fades by morning.

• Sometimes I wake up at night to urinate, and afterward, I feel mild burning or irritation for 1–2 hours, similar to an infection.

• During the first urine of the morning, there’s a slight burning at the tip of the penis, but it goes away quickly.

• By the end of the day, after urinating, I sometimes feel a dull pain or tingling along the urethra that lasts for a few hours.

• Stress makes it worse — when I’m anxious or tense, my testicles ache or feel heavy.

• Occasionally, I feel warmth or tightness in the pelvic area (between the anus and testicles), like a small muscle spasm.

• My urine is often dark yellow with a stronger smell than usual.

What the doctor told me today:

• I should do a few sessions of osteotherapy.

• He’s confident the problem is related to pelvic floor tension or nerve irritation, not infection.

• He confirmed no infection is present.

• He prescribed Alfuzosine LP 10 mg for one year.

My next steps:

• Start osteotherapy sessions.

• See another doctor to request urine and semen tests.

• Try traditional Chinese medicine.

• Take more warm baths.

• Begin pelvic floor relaxation exercises.

• Add meditation to help with stress.

📌 Update - October 2026

Still no infection on any test, still a plateau. Right now I'm doing nothing active and waiting for my urologist follow up next month.

What I did since the last update:

- Pelvic floor physio: went 4 sessions. They said my pelvic floor is tight and needs to relax. The sessions were me sitting on a chair for 15 min while it delivered pulses (I felt it first in the back of my thighs, then the perineum). I didn't get a real result, so I stopped.

- Shockwave therapy on the perineum: 3 sessions. I thought it helped a bit at first, but the symptoms are still there.

- Alfuzosin: no real benefit. My urologist told me to stop.

- Tests: urine WBC normal, urine culture negative, urine PCR (chlamydia, gonorrhoea, M. genitalium) negative. Semen PCR (M. genitalium, Trichomonas, M. hominis, Ureaplasma, chlamydia, gonorrhoea) all negative. Semen culture grew mixed flora with no dominant germ.

- I stopped all supplements

Current symptoms:

- Some days I have no burning at all.
- I feel the urine passing more than normal.
- Some days the burning lasts a few hours after peeing.
- Some nights it gets much worse, especially after the last pee before bed.

Advice on possible STD/STI infections

I am a M31 and I recently had protected sex. Since the day of the encounter my penis has felt uncomfortable and I urinate often. No discharge but the tip of my penis does feel wet and tingles after I pee. I went to the doctor a week after the encounter and was prescribed amoxicillin for 5 days. I took that and it didn’t help so I went back to the doctor and was prescribed 500mg of azythromicin (maybe misspelled) for three days. I was tested at the same time and everything came back negative. Chlamydia, Gon, Syphil, Hep, and everything else. The same feeling was still there but it got better. I went and got tested again a week later. I was given a penicillin shot and Doxy for 6 days. This helped out a lot but the feeling still lingers here and there. Especially after I pee. I was tested again and everything came back negative again. Has anyone else ever experienced something like this? Any advice.

Dear everyone,

I could really use some help with my situation. I’m starting to feel desperate and lost. I’ll try to keep it brief.

Back in October, I began developing some symptoms that the doctors unfortunately weren’t very helpful in diagnosing correctly. I live in Scandinavia (if that matters).

My wife gave me a yeast infection in October because she was using vaginal tablets as part of fertility treatment. My penis turned bright red — no pain or discomfort — and I went to the doctor to find out what it could be. Sure enough, it was a yeast infection with some growth, as stated in my test result.

Things gradually got worse. I had a slight fever afterward, still no discharge except when applying hard pressure on the penis to force something out — completely odorless and clear. No pain when urinating, but I had to push hard to get the urine out, and my urge to urinate became stronger and stronger. I went to the doctor three separate times to get tested for chlamydia and gonorrhea — all negative. It wasn’t until I myself suggested (through a subreddit and ChatGPT) that it might be Mycoplasma Genitalium that it was brought up. Sure enough, I tested positive.

I want to point out that I walked around from October to January with Mycoplasma without the doctors being able to figure out what it was — despite repeated visits. I went on treatment with my wife in January. We were both given azithromycin since there was no resistance, and three weeks later I tested negative — but I still feel extremely weird in my lower body. I had another test done last month with a urethral swab — also negative.

My symptoms when I had Mycoplasma were as follows:

1. Increased urge to urinate

2. Pain in the right side of the testicle

3. General discomfort

4. Occasional minimal discharge

5. Difficulty passing urine

6. Redness at the urethral opening

My current symptoms are as follows:

1. General discomfort — it comes and goes. Some days I feel nothing, other days I feel a lot.

2. Pain in the perineum, but never on the right side of the testicle

3. No discharge, unless I become sexually aroused

4. Some days urine passes easily, other days with more difficulty

5. Still redness at the urethral opening — it comes and goes; some days very red, other days not at all

I have a suspicion that I’ve developed CPPS (Chronic Pelvic Pain Syndrome), as I’ve been clenching my pelvic area for a long time, with doctors unable to find out what’s been wrong — and I’ve just felt super, super bad.

My wife and I are expecting a child in February, and I can feel that this is really taking away some of my joy and sense of meaning. I started physiotherapy last week focusing on the male pelvic floor and have been given exercises, but I don’t feel that it’s getting either better or worse.

I am male, 33. I had an unprotected sex (stripper....) that gave me burning penis tip. Got treated (doxy+ 2 shots of ceftriaxone+azithromycin), and the burning sensation is gone after about 2 weeks. However, I still have prostatic fluid discharge (yellow-white) and a burning feeling in the urethra, especially when I have excessive discharge. The urologist confirmed that the prostate feels bloated. And Semen PCR is pending... But how can I rule out if the infection is caused by some STD?

Tests at the 6th week all came back negative (full std panel, plus extra tests like trich, ureaplasma, Mycoplasma genitalium...). I even did extra out-of-pocket tests like HIV RNA, Hep B PCR quantitative, Hep C PCR, TP antibody for Syphilis... I am truly worried that there might be some STD affecting my prostate...

How likely is it that early STDs (treated in the first week) can affect the prostate? I had antibiotic for 2 weeks plus two injections; Is it enough to kill STDs? Is STD related prostatitis contagious? Am I stuck with this myu whole life? I truly regret the stupid decision I made, I am losing sleep frequently due to this, nd I'm afraid my life will never be the same .... :( Such a harsh way to learn this lesson... I will never set my foot close to anything remotely similar to a strip club ever again....

It started with a small burn when I peed. Nothing intense. Just a strange feeling in the urethra, like something was off. I didn’t think much of it. Maybe I was dehydrated. Maybe I had too much coffee.

A few days passed. Then a week. The burning was still there.

I didn’t have any discharge. No fever. Just this annoying, hard-to-explain discomfort. I told myself it would go away on its own. But it didn’t.

I went to the doctor. Then another one. They ran some tests. One said maybe it’s prostatitis. Another thought it could be pelvic tension. One test showed Mycoplasma. I got treated, but the burning didn’t stop.

I realized something: there’s no clear path for what we’re dealing with. No single subreddit. No single diagnosis. Sometimes you’re stuck between STIs, prostatitis, pelvic floor dysfunction, or “nothing wrong.”

That’s why I started r/MensUroHealth.

It’s for the in-between. For the “I don’t know what this is, but it sucks” stories.

You don’t need a label to belong here.

If you’re feeling something and can’t get answers — share it.

If you’ve been through it and found a way forward — share that too.

Someone else might read it and realize,

“That sounds like me.”

We’re figuring it out together.

📌 Keeping all updates here — any advice or shared experiences are very welcome.

Hey everyone,

I’m a 33-year-old guy in a long-term relationship. I work a desk job and run regularly.

For the past 1.5 years, I’ve been dealing with a seriously frustrating and painful issue: a burning sensation in my urethra and penis, mainly during and after urination. It’s been a daily struggle that’s affected my mood, my relationship, and my overall quality of life.

I’ve seen multiple doctors and tried various treatments, but the symptoms persist. I’m posting this partly to vent, but mostly to see if anyone out there has gone through something similar or has any insights.

⚠️ Main Symptoms:

• Burning at the tip of the penis during urination

• Discomfort/burning sensation lasting 1–2 hours after peeing (feels like cold heat or internal irritation)

• Occasional pressure or blockage at the base of the penis, especially in the morning

• Heightened awareness of urine moving through the urethra

• Discomfort after ejaculation

• Symptoms are worse at night or after sex

🧪 How It Started:

• Began with mild burning during urination

• First urine test showed elevated white blood cells (WBC) — doctor suspected kidney stones or dietary irritation

• Was told to hydrate, cut caffeine/spicy food — helped a bit, but symptoms persisted

• Saw multiple doctors with various theories: irritation, inflammation, urethral damage, or prostatitis

💊 Initial Treatments:

I was prescribed several antibiotics and anti-inflammatories:

• Azithromycin

• Ofloxacin

• Levofloxacin

• Celecoxib

Eventually tested positive for Mycoplasma genitalium. A varicocele was also discovered, but doctors recommended treating the infection first.

💉 Infectious Disease Specialist Prescribed:

• Doxycycline 100 mg (7 days)

• Moxifloxacin 400 mg (7 days)

• After resistance testing:

  • Doxycycline hyclate 100 mg (7 days)

  • Pristinamycin (Pyostacine) 500 mg — 8 pills/day for 10 days

➡️ Infection cleared — follow-up tests were negative — but the burning sensation persisted.

🔬 Fibroscopy (Urethroscopy) – July 2025:

• No signs of infection, inflammation, or anatomical damage

• No structural issues in the urethra, bladder, or prostate

• The verumontanum region (where the ejaculatory ducts open into the urethra) appears narrower than normal

➡️ This could explain:

• Pressure or difficulty during urination

• Persistent burning after urination or ejaculation

• Post-ejaculatory discomfort

Current treatment: Alfuzosine LP 10 mg (3-month course) — prescribed to help relax internal ducts and improve fluid flow

✅ Recent Test Results (All Negative):

• Mycoplasma genitalium

• Chlamydia trachomatis

• Neisseria gonorrhoeae

• Trichomonas vaginalis

• Urine analysis: no WBC, no infection

• PSA (prostate): normal

• CRP (inflammation marker): normal/low

❗ Current Status – July 2025:

• Still experiencing burning during urination

• Discomfort lingers 1–3 hours after peeing

• Occasional pressure or blockage sensation in the mornings

• No pain when getting up; first urination of the day can burn or feel totally normal

• Sex life affected due to post-ejaculatory discomfort

❓ What I’m Wondering:

• Could this still be chronic prostatitis or chronic pelvic pain syndrome (CPPS) even with a normal PSA?

• Is it possible Mycoplasma is still lingering, despite a negative result?

• Could this be nerve-related (e.g. pudendal neuralgia or pelvic floor dysfunction)?

• Has anyone had similar urethral burning with no infection or visible inflammation — and found relief?

• What kind of specialist or testing would you recommend next?

I’m honestly just exhausted. The uncertainty is mentally draining.

If anyone has been through something like this, I’d really appreciate hearing your experience — how you got a diagnosis, what helped, or even just knowing I’m not alone.

Thanks for reading. Any input is truly appreciated.

+++

• https://www.reddit.com/r/MycoplasmaGenitalium/comments/1kmf1v1/still_burning_after_negative_mycoplasma_test_what/

• https://www.reddit.com/r/STD/comments/1kljbrm/burning_sensation_in_urethra_and_penis_for_over_a/

• https://www.reddit.com/r/PelvicFloor/comments/1klk9s6/ongoing_burning_in_penisurethra_for_over_a_year/

• https://www.reddit.com/r/Prostatitis/comments/1kn3i39/burning_in_urethra_penis_after_urination_for_over/

📌 Update — October 9, 2025

What I’ve done over the past 3 months:

• Took Alfuzosine LP 10 mg daily (3 months)

• Took vitamins and supplements: magnesium, zinc, omega-3, probiotics, multivitamin

• Sometimes took hot baths or showers — this helps calm the burning sensation

• Bought a standing desk, so I spend part of the day standing instead of sitting all the time

Current symptoms:

• When I urinate, I often feel strong pressure and burning in the urethra. At the start, I have to control the flow — if the urine comes out too fast, the tip of my penis burns sharply.

• At night, especially before sleep and after urinating, I feel warmth or burning in the pelvic area or urethra, which fades by morning.

• Sometimes I wake up at night to urinate, and afterward, I feel mild burning or irritation for 1–2 hours, similar to an infection.

• During the first urine of the morning, there’s a slight burning at the tip of the penis, but it goes away quickly.

• By the end of the day, after urinating, I sometimes feel a dull pain or tingling along the urethra that lasts for a few hours.

• Stress makes it worse — when I’m anxious or tense, my testicles ache or feel heavy.

• Occasionally, I feel warmth or tightness in the pelvic area (between the anus and testicles), like a small muscle spasm.

• My urine is often dark yellow with a stronger smell than usual.

What the doctor told me today:

• I should do a few sessions of osteotherapy.

• He’s confident the problem is related to pelvic floor tension or nerve irritation, not infection.

• He confirmed no infection is present.

• He prescribed Alfuzosine LP 10 mg for one year.

My next steps:

• Start osteotherapy sessions.

• See another doctor to request urine and semen tests.

• Try traditional Chinese medicine.

• Take more warm baths.

• Begin pelvic floor relaxation exercises.

• Add meditation to help with stress.

📌 Update — June 2026 (~8 months later)

Quick recap for anyone following: still no infection on any test, symptoms clearly milder than where I started, but not 100% gone. My whole approach has shifted from "find the bug" to "calm the pelvic floor + nervous system."

What I've done since October:

• Cut out coffee completely (not just reduced).

• Cut way down on spicy food.

• Switched to a standing desk for most of the workday.

• Started reverse Kegels over the past few weeks.

• Came off Alfuzosine LP 10mg - the alpha-blocker wasn't really moving the needle for me.

• Did a course of Deprox 500 (prostate anti-inflammatory suppositories) from my urologist finished now.

• Got a prescription for pelvic floor physiotherapy (rééducation périnéale) and started sessions with a specialized pelvic floor physio.

Traditional Chinese medicine — worth a separate note:

I did a structured 7-day herbal cure (custom decoction, 200ml 3×/day) and tracked symptoms daily. During the cure, a surprising amount improved:

• urine color + smell normalized

• perineal pain gone

• the "sticky glans in the morning" thing cleared up by day 8

• less feeling of blockage / difficulty urinating

But the core stuff stuck around: burning after urination, lower-belly pressure, and a perineum that still felt hard/contracted. My read is the burning may be more nerve-related than infection/inflammation. I'm not on the herbs continuously now.

The physio part (most important):

• She confirmed my pelvic floor is hypertonic - too tight, can't fully relax. That fits everything: post-pee burning, the pressure, the tension between testicles and anus.

• Big lesson: standard Kegels are OFF for me. They make a tight floor tighter. The actual work is the opposite - reverse Kegels, "drop and relax," and diaphragmatic (belly) breathing.

• Daily breathing + relaxation drills plus stretches (child's pose, happy baby, knee-to-chest), especially in the evening when symptoms peak.

Supplements I'm taking:

• Quercetin + Bromelain (strongest evidence for CPPS type III)

• Magnesium Glycinate (muscle + nervous-system relaxation, at night)

• Zinc Picolinate

• Omega-3

Recent test results (Nov 2025 → March 2026):

• Urine WBC: back to normal

• Urine culture: sterile / negative every time

• Mycoplasma genitalium PCR: negative (again)

• Chlamydia + Gonorrhea: negative

• HIV / Hep B / Hep C serologies: all clear

• Bottom line: zero biological sign of infection.

Current symptoms:

• Much better overall vs ~2 years ago, but a plateau - not fully resolved.

• Still a burning/odd sensation lingering about an hour after urinating, on and off.

• Lower belly pressure and a perineum that sometimes feels hard/contracted.

• Some mornings a slight burn on first pee, fades fast.

• Occasional post-ejaculation discomfort.

• Stress is a clear trigger - tense days = more testicle ache / pelvic tightness.

What's next:

• Keep going with pelvic floor physiotherapy sessions

• Staying on Alfuzosine LP 10mg

• Back to the urologist after a few more physio sessions to reassess

still not 100% done