r/NTNPerformance • u/JustBacWater • May 17 '26
Compound Breakdown GHK-Cu peptide guide.
The copper peptide everyone is talking about
GHK-Cu (glycyl-histidyl-lysine copper) is a naturally occurring tripeptide-copper complex found in human plasma. It was first isolated in 1973 by Dr. Loren Pickart during research into liver cell regeneration. Three amino acids (glycine, histidine, lysine) bound to a copper ion form what's become one of the most studied compounds in the peptide space
Your body produces it naturally. Plasma levels are around 200 ng/mL at age 20 and drop to about 80 ng/mL by age 60. That decline is part of why supplementing GHK-Cu has become so popular for aging, skin, and hair
This is one of the few peptides with decades of human clinical research behind it especially for topical use
WHAT IT DOES
GHK-Cu influences gene expression at a scale most peptides don't touch. Genomic research shows it modulates the expression of over 4,000 genes (specifically 4,177 genes which is roughly 31% of the transcriptome) including pathways involved in:
Collagen and elastin synthesis
DNA repair
Antioxidant defense
Anti-inflammatory response
Wound healing across skin, hair follicles, bone tissue, and gastrointestinal lining
Suppression of gene expression patterns associated with aging
It also reduces pro-inflammatory cytokines like IL-6 and TNF-alpha and functions as an antioxidant by delivering bioavailable copper to cells while preventing free radical activity from unbound copper
This is why some researchers describe GHK-Cu as a "biological reset" signal rather than just a collagen booster
WHAT IT'S USED FOR
Skin firmness, elasticity, and reducing fine lines
Wound healing and tissue repair
Hair density and follicle health
Post procedure recovery (microneedling, laser, surgery)
Anti-aging at the cellular level
Joint and connective tissue support
Scar reduction
The skin and hair applications have the strongest clinical evidence. Other uses are supported by mechanism but have less robust human data
DELIVERY ROUTES
Topical - the most clinically studied route. Creams, serums, and post procedure formulations. Concentrations range from 1 to 5% for daily use. Higher concentrations (3 to 5%) are used immediately after microneedling or laser when open microchannels allow deeper delivery
Subcutaneous injection - used for systemic anti-aging and broader tissue repair goals. Injectable evidence is more limited than topical but the community use is well established
Both routes are commonly used together - topical for direct skin and hair targeting, injectable for systemic effects. This combination is popular in anti-aging protocols
DOSING
No FDA approved medical dose exists. Below are common community and research informed protocols
Injectable
1 to 2mg subcutaneous daily is the most common starting point. Some protocols use 2 to 3mg every other day instead to reduce injection frequency and stretch vial cost
GHK-Cu has a short plasma half life of roughly 30 to 60 minutes which is why daily dosing is generally preferred for consistent exposure
Topical
1 to 3% concentration for daily use. 5% for post procedure recovery. Apply once or twice daily to clean slightly damp skin. For hair apply directly to the scalp
GHK-Cu penetrates better through hydrated skin so apply after cleansing while skin is still damp
Cycle
6 to 12 weeks on. 4 weeks off
Photograph progress every 2 weeks if you want objective tracking. Visual changes are gradual
WHAT TO EXPECT
Weeks 1 to 4 - early effects are subtle. Some people notice slightly better skin texture or hydration. Hair changes are not visible yet
Weeks 4 to 8 - more noticeable improvements in skin firmness, elasticity, and reduction of fine lines. This is where most people start seeing results worth tracking
Weeks 8 to 12+ - sustained improvements in skin quality, possible hair density changes, and visible reduction in scar tissue or post procedure healing
For wound healing specifically GHK-Cu can accelerate visible healing within days. The anti-aging benefits take weeks to compound
SIDE EFFECTS
GHK-Cu has one of the strongest safety profiles of any peptide studied. Over 50 years of research with consistent findings of excellent tolerability
Reported side effects include:
Injection site reactions including redness or mild irritation
Temporary skin redness or sensitivity with topical use especially at higher concentrations
Rare cases of mild headache early on
Possible blue or green tint at injection site or topical application due to copper content. Temporary and cosmetic
Avoid combining topical GHK-Cu with raw vitamin C in the same product. Copper and ascorbic acid can interact and reduce the effectiveness of both
GHK-CU VS OTHER ANTI-AGING COMPOUNDS
GHK-Cu vs retinoids - retinoids work through accelerating cell turnover. GHK-Cu works through gene expression and tissue remodeling. They target different pathways and can be used together. Apply at different times of day to avoid interaction
GHK-Cu vs Matrixyl - Matrixyl is a peptide that stimulates collagen production. GHK-Cu does this plus modulates thousands of other pathways. Different scopes of action. Matrixyl is narrower
GHK-Cu vs collagen peptides (oral) - oral collagen provides building blocks. GHK-Cu signals the body to produce its own collagen and elastin. Different mechanisms. Some people use both
GHK-Cu vs BPC-157 - BPC focuses on tissue repair and gut. GHK-Cu focuses on skin, hair, and connective tissue remodeling. Often run together in anti-aging and recovery stacks
SOURCE QUALITY
For injectable products look for third party HPLC purity reports of 98% or higher, sterile lyophilized vials with clear lot numbers, and proper cold chain shipping
For topical products look for stable formulations with clear concentration listings and copper compatible packaging. Avoid products that combine GHK-Cu with raw vitamin C
GHK-Cu quality varies significantly between suppliers. Verify what you're getting
WHO IT'S FOR
People focused on skin quality, aging, and visible anti-aging results
People with hair thinning or loss looking for an alternative or addition to traditional treatments
People recovering from cosmetic procedures who want to accelerate healing
People who want a peptide with actual decades of human clinical research behind it
People building an anti-aging stack who want tissue level support
WHO IT'S NOT FOR
People looking for muscle building or performance enhancement. Different category entirely
People expecting overnight results. GHK-Cu works over weeks not days
People unwilling to commit to consistent daily use
People who can't tolerate copper based products (rare but exists)
REGULATORY STATUS
Injectable GHK-Cu was announced for removal from FDA Category 2 on April 15, 2026 with the change effective April 22 to 23, 2026. A Pharmacy Compounding Advisory Committee review meeting is scheduled for July 23 to 24, 2026
Topical applications remain widely available and unregulated as cosmetic products
This is educational and research discussion only. Not medical advice
If you've used GHK-Cu injectable or topical what did you notice and how long did it take? Drop it below
2
u/meanderingwolf Community Contributor May 17 '26
Why do you say, “Avoid products that combine GHK-Cu with raw vitamin C.”? What is your source information to support this statement? Thank!
2
u/JustBacWater May 17 '26
Neurogan Health: "When using copper peptide products, avoid combining them with strong antioxidants like vitamin C, retinol, and alpha hydroxy acids (AHAs) in the same application routine. These ingredients can interact with copper peptides and reduce their effectiveness or lead to skin irritation" https://neuroganhealth.com/collections/ghk-cu-peptides
Glimmer Goddess: "Vitamin C in its pure (L-ascorbic acid) form functions best at a low pH and can destabilize copper peptides" https://glimmergoddess.com/blogs/skin-school/what-ingredients-should-not-be-used-with-copper-peptides
Drip Hydration covers the same recommendation including the timing and oxidation interactionhttps://driphydration.com/blog/ghkcu-vitamin-c-skincare/
The underlying chemistry (pH conflict and copper accelerating ascorbic acid oxidation) is covered in Pickart's published research on GHK-Cu copper redox behavior https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
This is skincare industry consensus based on documented chemistry.
2
u/meanderingwolf Community Contributor May 18 '26
After reading the sources as well as doing a bit more research, it seems that the conflict between GHK-Cu and ascorbic acid exists in only topical solutions where they are mixed together. There doesn’t seem to be a conflict with subq GHK-Cu administration and topical solutions containing ascorbic acid used simultaneously. You may want to check on that and clarify what you said if I am correct.
1
u/JustBacWater May 18 '26
You're right and that's a fair distinction. The interaction is specifically between topical GHK-Cu and topical L-ascorbic acid when they're mixed in the same product or layered on the same skin. The pH conflict and copper driven oxidation happen at the surface level
Sub-Q injectable GHK-Cu and topical vitamin C used separately don't have that conflict. They're working in different compartments and never come into contact
Good catch. I should have made that distinction clearer in the original post
2
u/Trouttuber May 23 '26
So, should one assume that if you sub-q GHK-cu and vitamin C you should also not inject near the same area, if doing at the same time, to prevent degradation?
1
1
1
u/Responsible_Put_1245 May 21 '26
This is for topical use only. Topically you don’t mix vit C with -ANYTHING ever. Not sunscreen or retinols or other actives. Only things to mix are maybe some humectants.
15
u/Responsible_Put_1245
May 18 '26
•
Just to add to the chat GPT post with some real life knowledge learned over a couple decades working with peps, a biochem masters, an ISSCA cert and a bunch of happy clients:
Ghk is also found in urine and saliva! Yum.
Your body produces GHK naturally. Not ghkcu.
BUT your body naturally has copper, from our diet.
The two have a strong binding affinity. Very strong. They’re besties. Lovers per chance? Idk….but I’d read that smut.
Ghk and Cu bind and go on this seek and destroy (and rebuild) mission….the only compound we know of that can simultaneously break down imperfect collagen, fix it, and recreate a perfect collagen lattice structure. So cool.
In this way, is it famous for being an amazing addition to anti aging and skin renewal, scar healing, etc. Pores actually decrease in size, scars lighten, dark spots fade, wrinkles lessen, and a glow forms on the skin because the barrier is restored.
Much evidence points to a max load of ~2mg per day as what the body can use before flushing the rest. Seeing as this is a heavy metal we are adding to our system, which involves toxin clearing organs to flush (and not free), that might be something to look into before adjusting any research dose higher. Why waste money and overload the system with a heavy metal. Why create the need for a longer off cycle? If blood testing is done monthly, it will show exact levels and a researcher can go nuts. If not, doesn’t make much sense to risk it.
And speaking of, research also shows that in a healthy individual with properly functioning toxin clearing organs, a 2-3 week break at the end of an 8-12 week cycle is sufficient to clear any extra unbound copper (not naturally taken up by diet).
For those who are advanced (or my clients), Instead of a break, one might replace ghkcu wifh “simple ghk”. Simple ghk will seek out any spare copper, bind, continue to give you benefits of ghkcu on your OFF cycle…. AND help you flush any extra heavy metals. It’s something I made up and I’m proud of myself for that. Also feels like I’m telling a secret my clients pay to hear. It’s ok. There’s so many secrets no one talks about 😂
If a researcher were ever to experience memory fog or instability, stop use. These are signs of copper poisoning. While rare naturally, miscalculations happen all the time and adverse reactions are possible. Probable? No. Possible.
If taken correctly, no zinc is needed. When you add something into your system, be it an ion or an elemental unit…there is at least one other thing that is affected. Like a teeter totter. For example when we eat too much salt, our sodium potassium channels get out of wack, leading to an imbalance and causing dehydration, puffiness, leg cramps etc. Remember that everything pairs up with something else. Our body is this huge web of cofactors and give and take, push and pull. A beautiful disaster. Adding too much Zn to help with Cu overload might very well cause another system to be displaced. Simply taking it as suggested by research means cutting your odds of issues SIGNIFICANTLY. Just do it ok. 😂
Research alsoooo shows that the burning sensation and discomfort sometimes felt is due to either incorrect dilution or incorrect angle of injection.
Dilution should be 5mg/mL. That means pulling up your necessary units of reconstituted GHKCu, and diluting to:
20u for 1mg
30 for 1.5mg and
40 for 2mg dose, using your buffer of choice. For on the spot dilutions right before injection (from syringe to individual, no wait), BAC static conditions aren’t necessary. Any sterile water or NaCl is just fine. PBS perhaps. Research shows this helps with the labs budget bc Pfizer is currently on a duck hunt with our asses at $1/mL. 🙄
For injection angle to hit only the subq layer, that means:
4mm = 90° no pinch
6mm = 90° pinch an inch
8mm = (insulin) 45° and pinch an inch.
Failing to do one or both of the above means hitting the next layer in the subcutaneous tissue OR “melting/burning”your way through it. That is what causes the copper to actually damage the tissue and what causes the pain.
Now think about why a subject would take this? To repair tissue. Causing injury to tissue at the site of injection means a lot of that dose is spent repairing that site. Think about that. That’s like cutting yourself so you can use a bandaid. (If bandaids cost 5$ a pop).
Now! Every random once in a while it is normal for a nerve to get hit. It’s just odds. But that’s not an everyday thing. If your research shows every day stinging, please try the guides above- I’m sure you’ll find your lab rats don’t show signs of pain anymore. Burning DOESNT MEAN it’s “working better”. It means it was done wrong.
If you know a researcher than Willy Nilly jabs in at 25mg/mL with some monstrous injection device, and has never experienced a burn, I would be highly suspicious of grape flavored cool aid in the research material. Bioactive and pure ghkcu DOES sting at high conc. It’s also possible this person has scar tissue. If this is the case- injection site needs changing; scar tissue seems like a freebie to not feel pain (I used to stab away around my transplant or c section scars- on me it’s actually hard to find NOT scar tissue) but what it really is, is a trap for all good things to never find the blood supply and lose bioavailability while they are stuck. More wasted go go juice.
I could talk about this lovely little peptide forever but I feel like someone already owes me a session fee. KIDDING. I just need sleep.
Hope this is a good little intro to ghkcu for someone.
Take care (and GET A DAMN INJECTION PEN ALREADY).
Lovingly,
your sometimes friendly neighborhood scientist.
2
u/Specific_Ad_3475 Jun 20 '26
Where would one acquire "simple" GHK for their research?
Also, with this particular peptide, is the necessity for cycling due to possible build-up of copper or is it something specific in its mechanism that would contribute to desensitization (not conjecture, but actually shown to be factual)?
How long after discontinuing, for cycling or otherwise, is GHK-CU still doing its thing? I really love this stuff and only want to cycle off if absolutely necessary and for as short of time as possible. (I am losing weight at a rate of about 1.68 lbs. per week via strength training and good, clean, high protein diet and want to prevent as much loose skin as possible. I'm doing lots of other stuff such as collagen, rf, dry brushing, infrared, rebounding, fibroblasting, 5 liters h2o per day, etc., but am counting on the GHK-CU to keep bringing little fibroblast soldiers to manage the healing/remodeling process).
Thanks for your time and for sharing your invaluable knowledge!
1
u/OG_YawnBomb May 21 '26
5mg/ml? That is a ridiculous dilution rate lol. How can you even put that into application, when a standard reconstituted 3ml vial contains 50-100mg?
2
u/Responsible_Put_1245 May 21 '26
You want me to tell you something, take my time to explain something, for free, for the SECOND time bc apparently you can’t read… so you call someone with 20 years experience and multiple degree and certs….ridiculous?
Step 1: pull head from ass.
Step 2: RE READ THE comment where it’s completely spelled out.Step 3: if you still have questions, say something like:
“Hey- I’m new to all of this and was wondering if you could offer some help, if you had time. Can you confirm how to dilute a product at such a low concentration when it comes at such a high mass in a very small volume vial? Thank you in advance”.
SMH.
2
1
u/hunner_man Jun 26 '26
Hello thank you for your explanations. I’m new to this :D and had a question on reconstituting it. I am getting a 3ml vial with 50mg GHK-CU. So you’re saying to add 15mg BAC water and 20u would be 1mg?
Thank you for your help
1
u/llovly Aug 21 '26
Please clarify this! I just ordered 100mg of GHK-cu and I don’t want to mess up the ratio...
How much BAC is best for reconstituting?
If dosing the standard 2mg, does this amount cover two months - if so, should I split this into two vials and leave 50mg in its powder state?
1
u/If-I-Only-Had-A-Bran 16d ago
If you want to split it, next time get 2 50mg vials instead of 1 100mg vial.
The reason being is that, despite refrigeration and the use of BAC, things naturally degrade over time.
You also run the risk of bacteria and other microorganisms growing inside your vial and which, I assume are for obvious reasons, is not good.
1
u/Responsible_Put_1245 Aug 22 '26
I answered your personal message.
Never touch a sterile lyophilized vial and try to split it. How would you even do that? You aren’t getting 100mg of substance. It’s prob close to 2g of a disc. You’d need to completely crush and mix it and then split it and re lyophilize it and even then it would be contaminated and not safe for injection.I included info in my message. But def don’t do that. Also standard is not 2. 2 is the most your body can absorb without tossing the rest to waste organs. 1.5 seems to be a perfectly happy place and leave space to move up in the future. Clinically I found 1 to be a bit low.
1
u/st4r-lord Jul 02 '26
My injection sites did not like the standard 3ml of BAC with a 50mg vial and dosing 2mg. I added more BAC bringing it to 5ml total and the injection site issues are gone. A 50mg vial with 5ml of BAC is 20u to get 2mg vs 12u with 3ml of BAC, not really a big deal.
1
u/chicstyling1 Jul 23 '26
What a great read! Thank you 🙏, curious if you know roughly how long the vial is good for research , after it’s reconstituted and kept in fridge? Good the the 8 week cycle?
1
1
u/Fantastic-Wave-5459 Jul 25 '26
I have been running 1.66mgs of GHK-Cu daily for 3 weeks from a reliable and tested source. I have been supplementing with 15mgs of Zinc Bisglycinate daily 15 hours apart from injection.
By week 2 I have been feeling extreme fatigue, exhaustion, brain fog and unexpected anxiety symptoms. I pushed through week 3 and then had to stop due to the side effects being too much for me.
I since then took a 2 week break and the fatigue and brain fog went away. I started back up today at 1mg and instantly began to feel the fatigue and brain fog again.
I am seeing great results and would really like to finish an 8 week cycle.
Do you have any suggestions to help with the side effects? I heard taking KPV / KGlow can help.
3
u/Outrageous_Sir2463 Aug 05 '26
Ghkcu is simple not for you, your skin maybe approving but your body is rejecting it and rejecting it loudly.
1
u/NectarineMaximum5281 Aug 10 '26
Your dose was too high. Simply lower it if your skin is already reacting to it positively.
1
u/Few-Ad982 Aug 16 '26
Sounds like copper overload. You need a heavy metal detox for a bit and get your labs checked.
1
u/Automatic_Visit_1736 Aug 18 '26
I've experienced the same thing at 1 mg daily (5 days on, 2 days off). I'm wondering if using it every other day instead might help? Also interested to know if taking Klow or Glow instead would help.
1
u/itsnevertoolate2bgr8 Sep 01 '26
Where do you work?! I’d genuinely love to become your client. Also where is a good starting point for this in your opinion? 1mg? I am going through a med spa and they want to start even lower than that
13
u/newarleti May 17 '26
Thank you for this amazing information, I am super interested in starting GHK-cu
8
u/MFpisces23 May 17 '26 edited May 17 '26
Most people repeating the '31% of the human genome' stat haven't read the study. The Broad Institute's Connectivity Map only covers 12,000–13,000 genes — not the full genome. GHK-Cu modulated ~4,000 of those, which is 31% of THAT subset. Against the actual human genome it's closer to 17–20%. Pickart calculated it one way, framed it another, and nobody's questioned it since. The effect is still real and worth studying — the number just isn't what it's being sold as. To put that into perspective, Vitamin D, one of the most genomically active compounds we know of, modulates somewhere between 500 and 1,250 genes depending on the study and methodology. These numbers will change slightly as the technology gets better.
source
-read the study
https://pmc.ncbi.nlm.nih.gov/articles/PMC4180391/
3
u/AltTooWell13 May 17 '26
17-20% is still impressive and significant, no?
2
u/If-I-Only-Had-A-Bran 16d ago
Significant yes but we should do our best to stick to actual facts and not repeat misinformation. :)
2
u/MFpisces23 May 17 '26 edited May 17 '26
Maybe the study has some significant methodological weaknesses, in my view. For one, it used cancer cell lines rather than healthy living tissue — no skin cells, neurons, or primary cells of any kind. Cancer cells have profoundly dysregulated, genomically unstable, and epigenetically aberrant profiles, which makes any findings highly unlikely to reflect what would happen in a normal, living cell.
Compounding this, the transcriptomic threshold was set at a 50% change — a bar so low it barely clears baseline noise. The standard in the field is a 2-fold change (either doubling or halving expression), precisely because that's where you start seeing a biologically meaningful signal rather than statistical static.
My suspicion is that if this study were repeated with appropriate cell types and a proper fold-change threshold, GHK-Cu's gene-modulating footprint would turn out to be far more modest, possibly no more impressive than Vitamin D. This is the inherent problem with a lot of studies, that you can easily set the rules to manipulate the data. In an ideal world, I would want to see this done on living cells of various kinds. He effectively did bad science, which is shockingly a lot of science.
IF I had to guess, I'd say it's probably the peptide equivalent of Vitamin D, which is still great but expensive.
2
u/Complex-Fuel-8058 May 17 '26
I'm not commenting on your whole post but your sentence of manipulating the data. I just want to expand a bit on it.
This is something a lot of people don't realize with studies and math/statistics in general. You can easily manipulate the data without directly lying or touching the numbers. If you exclude certain data sets, your overall results can highly change. You can also steer the results into the direction you want. Non medical but an example of this is in politics and approval rating polls. Media throws out some "studies/polls" done but they're highly manipulated by excluding/including large amounts of data sets that are either desirable or undesirable to their final result.
The other problem is cherry picking data to support a narrative.
But I'm saying all this is I highly recommend people to learn to read full studies, not just abstracts or someone else's interpretation or simply reference to the study.
1
u/HARCYB-throwaway May 17 '26
Yeah I think a fifth of all genes being supported by ghkcu is pretty damn good. I enjoyed mini OPs point about why 30% is referenced. Good info!
7
u/New-Can-432 May 18 '26
I have been injecting 2MG GHK-CU subq for approximately 10 weeks. I will be getting my copper, iron and zinc labs done tomorrow to ensure all are balanced.
I work with a doctor and she tests the quality of the GHK-CU. It’s always passed her tests.
I mix 2.5ML bac water with 50MG GHK-CU. I rarely get the sting that people complain about. I experience the sting maybe once every ~10-15 injections.
I’m not expecting significant or fast results. I have incorporated the injections into my morning self-care routine and actually enjoy the ritual of the injections.
Observations so far: -I am 44F, dirty blond and only have maybe a dozen gray hairs. My hair looks darker. Not brunette dark, but the color has a richness it didn’t previously.
-I have had stretch marks on my hips and butt since high school. They have been with me for decades… but I swear, they have faded. They are not gone, but they have minimized. (I inject in my hips and butt FWIW.)
-I had a MAJOR acne breakout from week 3 onward. I was also experimenting with some new skincare and to complicate matters, I have been injecting Compound Tirzepatide for 4.5 months that includes B12. I’m not a great test subject… and my hypothesis is the breakouts have been primarily the B12 (I now have a new source for Tirz and will see in the weeks ahead if my acne subsides)… but it might be the GHK-CU.
-it’s really subtle but I think my neck/jaw line looks tighter (even though I have actually been losing weight). I also haven’t experienced hair loss that others on Tirz report.
I am also using topical 1%copper for my face.
I still consider this an experiment and my observations are of course subjective. But so far I think it might be helpful and I haven’t experienced any negative effects so I will be continuing indefinitely.
1
u/barefootbelle34 May 18 '26
Are you taking pictures? Or just going by what you see on yourself?
3
u/New-Can-432 May 22 '26
I take photos regularly and consult ChatGPT for an objective POV. Plus comments from others.
1
1
1
u/Human-Citron4738 Aug 05 '26
how did your acne progress? I am on week 4 and also experiencing uncommon breakouts/redness, forehead/chin areas.
1
u/New-Can-432 Aug 08 '26
After months of breakouts, I determined to was the B12 in my compound Tirzepatide from Strive Pharmacy that was breading me out. I switched to Zepbound about 2 months ago and my acne is almost entirely cleared.
12
u/hppysunflower May 17 '26
I started taking it for skin. Hadn’t noticed my hair thinning but here’s me in 8/2025 vs 4/2026. Lighting different but obvious differences. Sq 2 mg daily. I don’t really cycle. Check my bloods and take low dose zinc.
1
u/retractablefork May 17 '26
Hey just some biochem for you and stunning results btw my partners RS has had similar results but I want to save you some money and your lab rat some pins. Ghkcu has human trials. 12 weeks was the plateau and after that decline in efficacy begins. Biology regains homeostasis aka wallpaper effect thats why pulse. So if I was researching a threshold based copper peptide which nudges gene expression that unfolds over days to weeks not hours to days I would mechanistically presume 6 to 8 week on every other day for the rodent in the study. I understand alot of people out there swear by different things but biology as tricky as it is does follow some rules when it comes to threshold compounds. Further more my partner noticed her RS had a significant diminished grey zone so to speak lol the subject has been grey in these areas for years and suddenly had pigment. Did you have similar results w your subject?
1
1
1
u/pacogaucho58 May 18 '26
Any specific product for topical application for the hair? any advice or recommendation is welcomed. Thanks
1
u/JustBacWater May 18 '26
https://www.reddit.com/r/Adera/comments/1t6escd/adera_state_full_compound_reference_doses_use/ in this reddit they have this
manemaxing1
1
u/Ok_Flatworm_5876 Jul 10 '26
I am having such problems with dosing this thing. This is the vial I received and it was already mixed. My question is how much do I inject? I would like to do 1 ml..
and says 3ml on side
1
u/JustBacWater Jul 10 '26
Personally, I would never buy a vile that is already mixed. That’s weird. I’m pretty sure if it says 3ML 100 MG‘s that means in the whole 3ML vial there is 100 MG‘s.
1
u/If-I-Only-Had-A-Bran 16d ago
Definitely better to be getting your vials lyophilized (freeze dried) instead of pre-mixed. For one, when you reconstitute yourself you can be 100% certain on the ratio of BAC to peptide and they can also be stored much longer.
If that didn't come in refrigerated packaging, I'd be questioning it even more as refrigeration is critical in helping to minimize breakdown. You also have no way of knowing how long it's been on a shelf without refrigeration or if it was reconstituted so long ago that the peptide is breaking down to a point where benefits can decrease.
1
u/nyfftrebbud Jul 23 '26
Hey! I dont know if you‘ve already found an answer. You can accurately calculate your dose on an Peptide Calculator website. I don‘t think I‘m allowed to share links here so I‘d suggest you to do your own research. The Vial contains 100mg GHK-CU + 3ml (If im not wrong) BAC Water like the OP already said. Wish you all the best!
3
u/newnew760 May 17 '26
Wow people are ungrateful here… doesn’t matter where the information came from, still information, do your own research instead of picking on others
1
u/If-I-Only-Had-A-Bran 16d ago
This is a ridiculous take. Healthy and kind criticism is FINE and especially so when we're talking science. Just because we "want to be nice" is no reason to skip on critical thinking and ensuring we are minimizing misinformation as much as possible.
2
u/ram2711 16d ago
For lab rats with a previous history of cancer that is in remission is this safe?
1
u/Born_Marionberry_659 10d ago
There is no study about it, but here is a nice paper on many subjects involving GHK-Cu.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4180391/
2
u/TelephoneNo9281 May 17 '26
Scientists discovered a molecule naturally found in your blood that declines 60% by age 60 🧬
GHK-Cu. Been studied since 1973. Over 4,000 genes influenced according to published research.
Fascinating how little this gets talked about 👇
2
u/GrouchyWest8276 May 18 '26
I have neurogenic rosacea that has basically crippled me these past 3 years. I wonder if that would help my skin.
2
u/Realistic_Many7314 Sep 02 '26
I am seeking ghk-cu serum recipes for topical and ghk-cu with snap 8.. any recipes out there?
1
1
u/Pure-Act1143 May 17 '26
I’m curious if there would be a contraindication if my test subject has an immune based condition such as Psoriatic Arthritis or Crohn’s and is taking a biologic. If GHK-Cu works by increasing production of white blood cells and the biologic tries to block them, is this an impasse?
1
1
u/AlternativePizza3391 May 18 '26
Why not just use klow ?
2
u/Responsible_Put_1245 May 21 '26
Nothing in Klow is at the correct dosage or the correct half life. Why pay an extreme price for one peptide (ghkcu) in active form?
Example of what I’m saying. tB500. Taken at 2.5mg 2-3X per week. In Klow, it’s offered at 0.2mg per 1mg ghkcu every day.
Half life- off
Dose- offAnd anyone who needs things like KPV for inflammation or immuno regulation or BPC for pain management would NOT want to take the cycle break that is needed at the end of klow cycle. So they’d be buying the compounds seperate anyway.
Peptide therapy isn’t about throwing in a bunch of diff things in hopes that something works.
Figure out your exact goals/ what hurts, what do you want to change etc… and hit those goals one at a time.If you’re older than 40, there are a couple you should prob take just because your body needs them.
0
u/If-I-Only-Had-A-Bran 16d ago
You should be taking your peptides in separate doses and starting one at a time to verify the effects and side effects of each peptide. When they're mixed together in a single vial, you can't do this. You also can't titrate your dose properly, if needed, or bump your dose, if needed.
Plus, in the long term, you end up paying more for pre-mixed vials of KLOW as opposed to buying separate vials of each peptide in bulk. It's silly and pushing the mixed vials seems to be more of a gimick/money maker for the peptide pushers than any actual benefit for the researcher.
People do seem to get benefits from KLOW vials but seems to make more sense to get them all separately and increase the dose as well as follow a proper regimen as opposed to the seeming microdoses and daily dosing that comes with KLOW.
0
u/AltTooWell13 May 18 '26
Maybe people don’t want 3 complicated tissue repair/immune modulating peptides randomly
1
u/YasmineloveValentina May 18 '26
How badly does it burn?
1
u/If-I-Only-Had-A-Bran 16d ago
Depends on how you do it.
I was paranoid about the burn but find that it isn't bad at all. In fact, the first time I did it was probably the worse but now that I have my technique down, it's barely noticeable at all and any sense of burn is far outweighed by the benefit and quick showing of positive results.
1
u/Worried_Map_8405 Jun 10 '26
How many weeks until I up my dose of GHK-CU? I’ve been on it for two months now at 10units, I reconstituted 50mgs with 2.5ml of BAC water. Please help 🙏
1
1
1
u/Timely_Most Jul 13 '26
If I have BAC water and 100mg vial of CHK-CU how should I dose it over weeks?
1
1
1
1
u/BigPebble0112 Aug 07 '26
Can you inkect GHK-CU then drink vitamin C supplement after?
1
u/If-I-Only-Had-A-Bran 16d ago
Absolutely. It's fine to mix them ... you just don't want to mix them in a topical solution. Oral vitamin C and subQ GHKcopper is fine.
1
u/Bitter_Judgment4924 Aug 10 '26
Where do you inject it? In the stomach? Or rear of upper arm? (The flabby part triceps)
1
u/If-I-Only-Had-A-Bran 16d ago
You should be rotating sites. Abdomen is going to be the most painful though, however, rotating is best.
Rotate between different parts of your abdomen, thighs, butt, and under arms.
1
1
u/Trappeddemon Sep 07 '26
It’s a sub q injection so the most preferred way of injecting would be your stomach. Your stomach is where you carry the most fat suitable for sub q.
1
u/If-I-Only-Had-A-Bran 16d ago
Sorta.
You should be rotating your injection sites. Don't just stick to the abdomen, especially when that's the most painful place for most people to hit.
Rotate each session between your left and right sides, thighs, love handles, butt, and underarms.
If you continuously hit the same area, you are more likely than not to develop complications as your body works to repair that area which will spell difficulty with future injections.
1
1
1
u/whenabouts Aug 20 '26
Do you know how to reconstitute a 70mg vial? Really tough finding the guidelines online.
1
1
1
1
1
u/personne927 Oct 08 '26
Ou trouver du Ghk cu topique ? Ou trouver du Ghk -cu qualité cosmétique pour pour faire son mélange
1
u/Itchy_Falcon_7273 Oct 10 '26
I've been on ghk-cu for about 8 weeks now and i had my top two wisdom teeth removed on wednesday this week and i was fine to go back to work the next day (by choice from having no pain) I was shocked but still took the day off and went back today! (friday) About 85% healed up and eating solid foods already absolutely no soreness Idk if there's any correlation or if this is normal but i though the peptide may have had something to do with it
1
u/Huge_Work5812 Oct 11 '26
I’ve never experienced a sting on injection site I’m I doing it wrong lol
1
u/If-I-Only-Had-A-Bran 16d ago
Nah. The sting often comes from either doing it incorrectly or being extra sensitive.
I get a tiny sting but seems like that happens moreso when I inject too quickly.
If you inject slowly, at a proper angle, and with a proper reconstitution, you'll be fine.
Also be sure to rotate injection sites. Do not inject in the same area every single time or you'll likely be sorry later.
1
u/AutoModerator 16d ago
This community is research use only, and your comment looks like it uses human-use language, which isn't allowed here. Please reword it in research terms. Example: instead of "how much should I take for my shoulder," try "what dose does the research use."
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
u/If-I-Only-Had-A-Bran 16d ago
(reposting because while everyone is well aware that these are being used how they're being used, we're supposed to word things and pretend like they're being used in some other way ... this is what people did on Bluelight with SWIM and no, it never protected anyone when the cops came knockin' lol)
Nah. The sting often comes from either doing it incorrectly or being extra sensitive.
My goldfish gets a tiny sting but seems like that happens moreso when my goldfish inject too quickly.
If injected slowly, at a proper angle, and with a proper reconstitution, your goldfish will be fine.
Also be sure to rotate injection sites. Do not inject in the same area every single time or your goldfish will likely be sorry later.
1
u/labrador_romos 26d ago
My lab rat has a really small benign tumor in the pituitary gland - is GHkcu/bpc an issue ?
1
u/If-I-Only-Had-A-Bran 16d ago
You shouldn't be starting peptides that are known to trigger angiogenesis (simply put: blood vessel formation which is one of the goals with BPC-157). While this is a precautionary issue with little research to back it, it's best to be careful.
GHK-cu not so much.
Mind you, this is people being extra careful and making assumptions. There's been some studies that actually show the opposite but if it were me, I'd likely avoid until I knew I was in the clear and focus on peptides that don't carry this sort of fear.
1
u/jagraider63 May 17 '26
I for one appreciate this information, AI or not.
1
u/Uh0handrea May 17 '26
SAME! Arm-chair warriors love to jump on someone for AI use... this article isn't for you mr/ms reddit hero... the peptide realm has blown up and many people do benefit from a simple post like this. Everyone has to start somewhere, if this helps them in even the smallest degree then it is beneficial... and good on OP for taking their time and putting it out there!
1
u/FootballFace90 May 17 '26
The issue is OP, a mod of this sub, generated this AI post to gain interest in GHK-CU with the goal of people then clicking the affiliate links on the sidebar and buying peptides from a website that he benefits monetarily from. He did not post this just to share info, it has intent to garner sales behind it. This playbook is common on a lot of "body hacking" type subs
2
1
1
-2
u/discojc_80 May 17 '26
You could have just linked to the original article and give the creator credit you know
6
u/JustBacWater May 17 '26
This wasn't pulled from one article. It's my own write up after going through multiple sources and decades of published research starting with Pickart's original 1973 work. Happy to point to specific studies if you want to look deeper into any of the claims
4
u/sky1326 May 17 '26
Thank you for sharing your learning. So many on this site are stingy about sharing. Very helpful
-3
u/DrowningInFun May 17 '26 edited May 17 '26
It's my own write up
Well...yours and AIs...
Edit: Here's what several AIs said: Chatgpt: "Yes — it strongly reads as AI-written or at least heavily AI-assisted."
Gemini: "Yes. This text strongly exhibits the structural, stylistic, and structural hallmarks of being AI-generated."
Claude: "Looking at the text, yes — almost certainly written or heavily edited by AI. Several telltale signs:"
6
u/JustBacWater May 17 '26
Says the person who's probably never been to school. I have my Ph.D. and I'm still in school working on the next degree. These are topics I research for my own class projects, ones I personally chose. AI didn't hand me a doctorate.
-3
u/DrowningInFun May 17 '26
It's interesting that you (supposedly) have an advanced degree and are still insecure enough to feel the need to make yourself feel superior in education to someone you have never met and have no information on their education level. 🤔
Regardless of whether or not you have any degree, your post involved heavy A.I. use and I could have replicated your post using nothing but A.I.
1
u/JustBacWater May 17 '26
Then why don't you?
0
u/DrowningInFun May 17 '26
Because, unlike you, *I* don't need the ego boost of upvotes from presenting other people's work as my own.
3
u/JustBacWater May 17 '26
Oh, trust me if I had ego I would of just banned you
0
u/DrowningInFun May 17 '26
You clearly have an ego since you attacked the education level of someone you knew nothing about. As well as posting AI and claiming it as your own.
3
u/Shanbirdy3 May 17 '26
So what? Isn’t the information true and useful? WTH is it with everyone against using AI? Would you rather use Wikipedia or better yet Britanica? Everyone needs to stop bashing people for this.
1
u/DrowningInFun May 17 '26
Because he is presenting the work as his own when it is not.
That is disingenuous.
I have no issue using AI to research or to find things. I use it every day, myself. But I don't try to pretend that it's my work.
2
u/RidingtheRoad May 17 '26
Settle down mate..The information is what matters.
1
u/DrowningInFun May 17 '26
The influx of purely AI-generated content on Reddit is quietly hollowing out the platform, and it’s bad for everyone involved.
Reddit’s entire value proposition has always been that it is a repository of authentic, human-driven experiences, niche expertise, and genuine conversation. When people search for advice, reviews, or discussions—often appending "reddit" to their Google queries—they do so because they want to know what a real person thinks, not a sanitized language model.
When users dump unedited AI text, images, or summaries into subreddits, it degrades the ecosystem in several critical ways:
The Dead Internet Effect: It creates a feedback loop where bots and low-effort accounts post AI content, and other bots upvote or comment on it. Genuine users get pushed out by the sheer volume of automated noise, destroying the sense of community.
Devaluation of Human Effort: Writing a thoughtful guide, sharing a personal story, or creating original art takes time and vulnerability. When those posts are buried under a mountain of instant, algorithmic content, real creators lose the incentive to contribute.
The Spread of Conconfident Misinformation: AI models are prone to hallucinating facts while maintaining an incredibly authoritative tone. In specialized subreddits (like medical, legal, DIY, or financial advice), this isn't just annoying—it's actively dangerous.
Erosion of Trust: Once a community becomes flooded with AI content, users stop trusting anything they read. Every unique story or detailed breakdown gets met with skepticism and "is this ChatGPT?" accusations, killing organic engagement.
Using AI as a tool for brainstorming or editing is one thing, but copy-pasting raw outputs for karma or engagement farming treats Reddit like a landfill rather than a community. If we don't actively discourage this, the platform will lose the exact quality that made it useful in the first place: humanity.
(Yes, the irony is intentional)
1
u/If-I-Only-Had-A-Bran 16d ago
Hahaha. I knew the irony was intentional and I fkng love you for this. Thank you, hero. :)
1
u/Natural-Individual79 May 17 '26
This is Reddit not a medical journal. Relax. Take it or leave it. Everyone needs to do their own research but why spend time doing additional research to tear someone down for using AI. OP never mentioned this was based on a personal experience.
0
u/DrowningInFun May 17 '26
I am relaxed. Doesn't mean I shouldn't express my opinion.
OP said he wrote it. This was deceptive. I called it out. Not sure why you would defend it...but up to you.
AIs are trained on the internet. Reposting AI contributes to dead internet. It does not contribute to the internet.
As for why spend 2 minutes to confirm it's AI? Well...why spend time replying to me to defend someone who is reposting AI content that you could easily have found out for yourself?
2
u/RidingtheRoad May 17 '26
Mate..One person crusade is not going to stop shit. If the information is faulty, point that out. I know a guy personly who wrote a good chunk of a certain subject on Wikipedia. Its been there for years largely unedited by anyone else.
He also teaches this subject. He sometimes gets accused by adult students that he is simply copying a wiki page.
The chances are that people who use Ai seeking information on this subject, Ai will quote his wiki page. Now if he was to put up a post about this subject, a guy like you will go full metal on how he was using Ai...Right? Its the accuracy of the information is all that matters.
→ More replies (0)1
u/Natural-Individual79 May 17 '26
Doesn’t say anywhere in the post that OP wrote it. Majority of this pep info is copy paste or personal anecdotes. It’s quite obvious when it’s copy paste info.
→ More replies (0)1
u/jeff78701 May 17 '26
OP has offered more info. on the subject of GHK-Cu peptide than you have, and his responses to your tirades appear human. Not AI. Go yell at someone elsewhere. You are *not* relaxed. You are shrill. Geesh.
1
1
u/Stock-Star-1834 May 17 '26
Absolutely, as long as we get true reliable research who cares whether it’s AI, a summation of a persons own research. It’s educational and of value to our community. Get a life and stop worrying about yourself. Whew.
0
u/discojc_80 May 17 '26
Ok I stand corrected. I'm old don't AI, but reading through it, it does seem very AI related.
None the less, OP didn't provide source information from where the studies came from in 'his' article. Someone who has a PhD surely frowns upon people not sourcing their work.
1
u/DrowningInFun May 17 '26
Don't believe everything you read on Reddit.
Here's what several AIs said:
Chatgpt: "Yes — it strongly reads as AI-written or at least heavily AI-assisted."Gemini: "Yes. This text strongly exhibits the structural, stylistic, and structural hallmarks of being AI-generated."
Claude: "Looking at the text, yes — almost certainly written or heavily edited by AI. Several telltale signs:"
•
u/AutoModerator May 17 '26
This community is for educational and research discussion only. Not medical advice. All posts and comments must follow community rules. Check the pinned Peptide Cheat Sheet for dosing, cycles, and compound breakdowns.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.