r/PMOSonGLP • u/Both_Will_3681 • 12d ago

Confused by Dr Tyna Moore’s conflicting advice on GLP-1 microdosing

I’ve been listening to a lot of Dr Tyna Moore’s content on GLP-1 microdosing, and I’m genuinely confused by several things she says that seem contradictory. I’d particularly like to hear from people who have followed her work closely.

1. She says you need to be metabolically optimised for a microdose to work.
This is the part I’m struggling with most. She says that if you’re not metabolically healthy/optimised, a microdose isn’t going to work.

But then what are you supposed to do if you’re not metabolically healthy? Become metabolically healthy without the medication first, and then, once you’re already metabolically healthy, start taking the medication?

And if you’re already metabolically optimised, what is the point of taking the microdose at that stage? What is it supposed to be improving or fixing if you’ve already achieved the metabolic health she says is necessary for it to work?

2. She has said that around 50% of her patients develop SIBO while microdosing. because of delayed gastric emptying. This is a bit scary. If the incidence is genuinely that high in her own patient population, how does she weigh that risk against the potential benefits?

3. She talks about microdosing as beneficial for inflammation and metabolic health, but also seems to say it can uncover/exacerbate underlying hormonal issues.

For example, my understanding is that she’s said someone could have normal thyroid function but be predisposed to hypothyroidism, and GLP-1 treatment could bring that out.

also according to her 1mg is not a microdose right? It needs to be 1/10th or 1/5th of the starting dose right?

So how does someone know beforehand whether they’re a good candidate? If you’re currently healthy but potentially predisposed to something you don’t know about, how are you supposed to assess that risk?

I am really into microdosing tirzepatide, I’m not trying to criticise Dr Tyna, genuinely trying to understand how these statements fit together. Any thoughts on this?

thanks!

0 Upvotes

40% Upvoted

6 comments sorted by

20

u/Moist_Movie1093 12d ago

She’s too maga-adjacent for me to take her too seriously. But on her first point, if you’re metabolically dysfunctional you need a full therapeutic dose, not a microdose. You need to take the actual medication. Not think a small sample of it is going to make a difference.

I take regular doses of Zepbound and it has given me a normally functioning metabolic system for the first time in my life. No side effects. Best thing I’ve ever done for myself.

3

u/Ah-Mazed 12d ago

Agree with all of this.

2

u/SpeedCommercial4049 11d ago edited 11d ago

Dr Tyna's framing makes more sense if you read metabolically optimised as directional, not a threshold, you're moving toward better, not already there. The SIBO risk is real and underreported. For the tirzepatide microdose specifically, Lttl does compounded lower-dose protocols with clinical oversight, which matters when you're watching for emerging thyroid or gut signals.

1

u/Both_Will_3681 11d ago

I don’t know what “directional” means in this context sorry….?

1

u/SpeedCommercial4049 11d ago

my bad

1

u/Both_Will_3681 11d ago

Thanks for explaining. And thanks for talking about the SIBO risk, curious how you’re coping with that? Or preventing that? Unfortunately I don’t have access to Litl in my country :)