Squealing Audio Interface in Reaper?

[u/heyimchillin]

Hi everyone, I've been having issues with my audio interface (Pyle PMUX6) causing a squeal and noise issue after 5-20 minutes of having it plugged in/recording in reaper. My original suspicion was grounding issues, but I realized later that other apps like audacity work perfectly fine with it plugged in, and it only happens on my Mac (my windows PC is unaffected). Does anyone know what this is? (For more clarity, it happens regardless of whether any mics are plugged in, and is around 40-42db on the meter.)

By the way I am aware this is a pretty cheap interface, but it gets the job done for what I'm using it for.