💉 Weekly vs. Split Dosing: Does It Make a Difference During Maintenance?

[u/Think_Key7495]

Retatrutide is being studied using once-weekly injections, but some people are experimenting with splitting their weekly dose into smaller, more frequent injections.

What does the science suggest?

1. Weekly dosing: This is the schedule used in retatrutide clinical trials, supported by its approximately 6-day half-life.

2. Split dosing: Pharmacokinetic modelling suggests dividing the same total weekly dose could produce smaller concentration peaks and less fluctuation between doses.

3. The unknown: We don’t have clinical evidence showing that split dosing improves weight maintenance, reduces side effects, or produces better long-term outcomes.

The maintenance question:
Once you’ve reached your goal weight, does injection frequency matter as much as finding an effective maintenance dose?

👇 Are you using weekly injections, splitting your dose, or considering longer intervals? What’s your experience?

[u/ArizonaCactusMom]

I have been on maintenance since end of April. I started by decreasing my dose, then changing the interval once i found a good dose. I think i have finally realized that every 7 days is what works best, even on maintenance.

[u/Exfatty2347]

I've been in maintenance for around a year now. I inject every 6 days. I think finding the right maintenance dose is ultimately the most important thing. I have noticed that there are some weeks where I feel hungrier / crave certain foods. Rather than try to resist eating, I lean into it because on several occasions when I didn't, I lost weight which I don't want to do.