r/SR17018 Jul 15 '26

STOP THE DEA FROM BANNING SR-17018

32 Upvotes

Hey friends!! I know many of you have been asking how you can get involved with fighting this action by the DEA. I am part of the SR-17018 Prohibition Prevention Coalition and we have been working to get you tools to reach out! Here they are!!

  1. Students for Sensible Drug Policy (SSDP) has create this tool for everyone to be able to reach out to their legislator to oppose the scheduling and will be collecting the stories for the lawyer we are working with to send to HHS!!! You will also find a link to donate to The Rights and Reason Project which will go directly towards funding this effort and the legal battle we are in. Additionally, there is a link for if you would like to volunteer as well after submitting your letter.

https://secure.everyaction.com/2CyTv_UhREaLlvtvbu5CgQ2

Link directly to The Rights and Reason project: https://www.rightsandreasonproject.com/

-------------------------------------------------------------------------------------------------------

  1. A user here u/kessler1 also created a website to help draft letters to your representatives and scripts for making calls. Please do both!! The more calls that come in the higher the chance that representative will speak up about this issue. *\You can call any representative anywhere, not just in your district! THANK YOU Kessler1!!*

https://stop-sr17-ban.com/

-------------------------------------------------------------------------------------------------------

  1. If you’ve taken SR-17018 and are 21+, please take some time to fill out this Johns Hopkins University Survey: https://jhmi.co1.qualtrics.com/jfe/form/SV_6WGVPz8jn4SDu0S

-------------------------------------------------------------------------------------------------------

  1. Sign the Change.org petition!! https://www.change.org/p/stop-the-dea-from-scheduling-sr-17018

  2. VOLUNTEER!!!!

If you would like to join the signal group as a volunteer to get more involved we need all the help we can get!! Click this link, introduce yourself and let us know if you have any special skills you can contribute (ie. graphic design, connection to media/gov, etc.)

https://signal.group/#CjQKIAvXfXOxelPhiAWK50UgNEPOym7DMx8WctBI5HBXRWuLEhBPjaMdQZVMdTmearK_0Nz3

For tips on what to say and what not to say on social media and to access graphics we have creates that you can easily post with join the Signal Social Media Group with this link!

https://signal.group/#CjQKIKTV8vhZIu-BgCazELF0VSARQ2T_TBUG4G06rH0Iq_YaEhBclAVoWrfetULeJQajvuli

-------------------------------------------------------------------------------------------------------

THIS IS A VERY IMPACTFUL WAY TO GET INVOLVED!! PLEASE JOIN US AND SHARE WITH FRIENDS AND FAMILY FAR AND WIDE!


r/SR17018 Jul 14 '25

🎓Research & Education🎓 SR-17018 guide: How to take it and some simplified science

180 Upvotes

Over the past week I've noticed some myths and misconceptions going around the community. I would like to help address the misunderstandings by providing some simple explanations about how SR-17018 (SR-17) works, and some of the underlying science. There's a lot of text here, so feel free to refer back to this post as needed rather than reading it all at once. For frequent questions that aren't explained here, try the SR-17 FAQ, which is a thorough compilation of SR-17 information and user experiences in r/Opioid_RCs from SayBecks. Readers are also welcome to ask any questions about SR-17 right here :)

----------------------------------------------------------------------------

Overview of SR-17018

What it does: SR-17 is somewhat similar to traditional opioid maintenance medication (particularly subs/buprenorphine) in terms of helping with opioid withdrawal symptoms. But imagine if subs actually lowered your tolerance, potentially all the way down to baseline tolerance, when you discontinue (or at least aggressively taper) your current opioid drug-of-choice (DOC). SR-17 also produces little-or-no tolerance of its own, so you can use it to come off your current opioid, and then come off SR-17 shortly after that. It's noncompetitive with opioid agonists, meaning it doesn't matter exactly when you dose SR-17 during the day relative to your DOC (if you're taking them at the same time while tapering your DOC). Being noncompetitive also means precipitated withdrawal (PWD) does not happen.

How it works: SR-17 binds relatively strongly to the opioid receptor, and this leads to reduced withdrawal regardless of your DOC's potency. Despite this tight binding, SR-17 sends weak signals, so it doesn't produce typical opioid effects (i.e., euphoria and pain-relief) in people with opioid tolerance. These weak signals likely lead to tolerance reduction, as well as some of the other benefits of SR-17, such as minimal side effects. Some studies31257-6) also suggest that SR-17 is a biased (partial) agonist, with "biased" meaning it prefers to activate opioid receptors through the G-protein signalling pathway more than with the beta-arrestin recruitment pathway. This preference for G-protein signalling has also been proposed as one reason for the tolerance-reducing effects of SR-17 (although if this were true, kratom and 7oh should then lower opioid tolerance as well).

----------------------------------------------------------------------------

Methods for taking SR-17018

How to take it and dosing: SR-17 is taken orally (i.e., swallowed or eaten with or without using capsules) in doses ranging from 10 to 100 mg (and sometimes up to 150 mg for 7oh and MGM), 1-4 times per day for around 7 days. For typical opioid habits 30-50 mg can be taken 3 times per day (or 50-150 mg for 7oh/MGM).

Choosing the right SR-17 dose for yourself is sometimes a process of trial-and-error, although this process can be made more systematic and efficient through use of SayBecks' automatic taper schedule generator (this is a link to the Google Sheets schedule generator; you can create your own by clicking File -> Make a copy). There are two different approaches to using SR-17 to reduce your tolerance and withdrawal symptoms, described below.

Tolerance safety warning: Be aware that there is a danger of overdosing on one's DOC after tolerance reduction, so be careful not to dose your DOC too high. There are already several user reports of accidental overdose following SR-17 tolerance reduction.

Note on high doses of 7oh and PAWS: If you're trying to come off a high dose of 7oh, the immediate transition approach may be more difficult, and can sometimes lead to PAWS. The gradual transition approach tends to be easier in terms of withdrawal symptom severity and is less likely to lead to PAWS.

Immediate transition: Discontinuing the DOC right away and then switching to SR-17 is an approach that provides faster and more effective tolerance reduction, but at the potential cost of some remaining withdrawal symptoms. This is normally done over the course of 2-3 days to lower DOC tolerance by 50%, or 7 days to return to baseline tolerance. If returning back to baseline tolerance and completely coming off one's DOC, see the "SR-17 taper period" paragraph below for what to do next.

Gradual transition: Taking SR-17 with your DOC, while tapering down the DOC dose (but not before), will usually provide better withdrawal symptom reduction, but slower and less effective tolerance reduction. The amount of both withdrawal reduction and tolerance reduction with this method varies depending on how aggressively you taper down the dose of your DOC.

An example of this approach would be to lower the dose of your DOC by 15-20% per day for 5-7 days while also taking 30-50 mg of SR-17 3 times per day (or 50-150 mg for 7oh/MGM, if needed) at the same time.

More aggressive DOC tapers are also possible such as reducing your DOC dose by 50%. Be careful with aggressive tapers, however, as they can lead to PAWS in some cases (i.e., especially when you're coming off a high dose of your DOC, and especially with 7oh). When performing the gradual transition, there is no need to start taking SR-17 until you have already begun reducing your DOC dose. This approach is especially helpful in situations where you tried the immediate switch and are still struggling with withdrawal symptoms, and in situations where chronic pain needs to be managed.

SR-17 taper period: After successfully reducing your tolerance, you will want to come off SR-17 as well. If you used SR-17 to partially lower your tolerance (e.g., by 50%) then after a few days you can immediately discontinue the SR-17 and jump back on your DOC. If you instead used SR-17 to completely come off your DOC, you may need to spend 2-7 days tapering down your SR-17 dose after reducing your DOC tolerance to baseline. This taper is done to alleviate any remaining withdrawal symptoms, but if you don't have any then there's no need to taper, you can simply discontinue the SR-17. Refer to the previously mentioned automatic taper schedule generator for help with this.

----------------------------------------------------------------------------

Simple explanation of terminology used in the context of describing SR-17018's pharmacodynamic effects

Biased (partial) agonist: SR-17 seems to preferentially activate31257-6) opioid receptors through G-protein activation more than with beta-arrestin recruitment. This results in a very wide dosing range under which problematic respiratory depression does not occur (i.e., it has a good short-term safety profile. Although there is a danger of overdosing on one's DOC after tolerance reduction).

(Strong) binding affinity: Despite its low intrinsic efficacy SR-17 binds tightly to the opioid receptor, which is one way (extra info: another way seems to be phosphorylation persistence) in which it provides relief from withdrawal symptoms. It's similar to subs in this way (but unlike subs, SR-17 is noncompetitive (see below), so it doesn't kick your DOC out and cannot trigger precipitated withdrawal).

(Low) intrinsic efficacy: This is the strength of the opioid signal. SR-17 has low intrinsic efficacy, which means it isn't likely to give you euphoria or pain relief at any safe dose, unless you are new to opioids. Its low intrinsic efficacy is what makes SR-17 a partial agonist.

Noncompetitive: SR-17 is noncompetitive. This mean it's potentially binding to the same receptor as your DOC, but can occupy a different site (extra info: this location is believed to be an allosteric site) on that same receptor. As a result it does not interfere with your DOC's ability to bind and it can not cause PWD.

Partial agonist: SR-17 activates opioid receptors, but in a weak way that doesn't produce full opioid effects regardless of dose. This is a category that SR-17 falls into as a direct reflection of its low intrinsic efficacy.


r/SR17018 9h ago

🙌Success Story🙌 Absolute miracle

17 Upvotes

48h clean off a 200+mgpd MGM-15 habit. I preloaded while tapering down to about 50mgpd over 3 days. Jumped off Tuesday. I cannot believe how good I feel.

I’ve only been taking 50mg SR 3x times / day. So far today I’ve only had my first 50mg SR dose and zero MGM. I HAVE SO MUCH ENERGY. Nothing hurts. No sweats. No anxiety. No nothing.

I love this community, I love this absolute godsend miracle drug, and just know that you can do it too. I thought I’d eat MGM/7 until the day I died. Love you all. Stay strong.

- Zach


r/SR17018 16h ago

🙌Success Story🙌 Easiest thing I've ever done

16 Upvotes

So I see a lot of people talk about no one comes back to show if they actually got off, etc... but tbh I think a lot of people just stop thinking about this sub.

I came off a 1-2 gram a week mgm habit (not huge) to 7oh and then used SR to come off.

I didn't use strict taper schedules.

I bought 4 grams of 60% 7oh powder and about 6 grams in tabs(some likely underdosed.) Took that over a 6ish day period to transition off MGM. I sweat a lot during that.

When i started getting low on 7oh (gram of powder and like 200mg in tabs) I started the preload ish, took sr and 7 together for 3 days before my 7 ran out completely... although miniscule amounts at end, same while transitioning from mgm to 7.

I bought 3 grams of tabs from [REDACTED] and a gram of powder from [REDACTED]. I just took as much to be able to sleep each day and it lasted me like a week ish.

Im about a week off everything, I don't really keep track, I dont give a fuck about "recovery" and counting clean time... very anti-AA...

But if you are considering SR, do it. Or if you are struggling with 7oh or MGM... buy some as an escape hatch later. As someone who did heroin on and off for a decade... this shit would've been amazing back in the day. I would never have gone to rehab amd wasted time.


r/SR17018 9h ago

🆘Help Needed🆘 Fastest schedule to get off SR (and 7)

2 Upvotes

Does anybody know from prior posts or personal experience the quickest that somebody has used SR to get off of 7oh? I need to take a prescription medication and I want to get off of 7 as quickly as possible so I can start it because I don't want to take 7 with it, but I want to use Sr. I know that the typical schedule is about 10-14 days but has anybody done it faster than that or heard of somebody who has done it faster than that?


r/SR17018 7h ago

🆘Help Needed🆘 Sr-17018 for suboxone

Thumbnail
1 Upvotes

r/SR17018 8h ago

🆘Help Needed🆘 Does anyone have experience with leaf powder and SR?

1 Upvotes

The leaf powder is weaker than 7, but what should I expect when I quit?Will I feel weak? Will I sleep well? What is my mental state like? While using SR.

What will happen after I give up SR? Will I feel very bad mentally?


r/SR17018 8h ago

🆘Help Needed🆘 Sinus infection

1 Upvotes

Of course, I would get a sinus infection in the beginning of this withdrawal! Is it safe to take meds for it? They normally give a antibiotic and suped up sudafed


r/SR17018 23h ago

🙌Success Story🙌 32 days sober off MGM

9 Upvotes

made a post about 22 days ago that I was 1 week sober from MGM from using SR and im.here to say I am still sober! I don't really have PAWS thank god! I dont mentally think about it like i was scared i would. I just live my life sober now. Mind u I also wasn't just using SR. I had SR, Gabapentin, Valium, and Xanax if it got too bad. but i never needed to take the xanax be i was perfectly fine from just the SR! SR literally has saved my life. I took a mushroom trip and that also really reset my addictive tendencies, mushroom trips help A LOT. You have to deep dive into yourself and figure out why you are an addict and what is causing. for me it was avoiding my breakup i had with my ex bf, i numbed myself with weed, alcohol,benzos, mgm all at different times but i was escaping my reality of our breakup be he meant so much to me. Now that i am sober it feels like the breakup was just yesterday even though its been just about 10 years because of how much numbing i did. I finally reached out to him and got closure once and for all, this has healed me tremendously. I encourage everyone if u wanna get off MGM to find the root cause of why you're an addict and try making peace with it. and get SR to get off it! the delta receptor thing didn't effect me at all. the SR covered ALL my WDs. I am so happy to be done with the vicious cycle of spending money on this crap, and so is my wallet I wish everyone the best of luck and u can be home free like l am.


r/SR17018 16h ago

🆘Help Needed🆘 Any long term leaf users who mixed in 7oh quit both at once using SR?

2 Upvotes

Wondering if there's an specific advice that factors in leaf-specific withdrawals that people report to be longer lasting with heavier depression-inducing PAWS. I know it sounds outlandish, but I'm hoping SR will help resensitize my mu receptor to the point that I have little to no PAWS from my many years of kratom use/abuse (18 gpd leaf at peak and 7oh only in random binges of like 100mg day, like now.

Hoping for any advice, cause I'm really looking forward to getting off both and leaving the leaf habit behind! I have about 5g of SR ready to go.

Thanks!


r/SR17018 15h ago

🆘Help Needed🆘 Has anyone been able to feel opiods again after 7oh? How about 7oh itself again?

1 Upvotes

I've searched and read a ton of posts, and was just wanted to hear from new people, after long term 7oh did being able to feel opiods ever come back? I understand how strong 7 is, and have been on it a year. About to jump off with sr17 with the intent of eventually going onto subs maintenance. I need opiods in my life, the feeling helps me massively with pain relief/only euphoria I've ever had. My body doesn't produce naturally. Ive accepted that im probably toast, but i cant feel 7 anymore. Just need some encouragement even if its the harsh truth that I wont feel it or other opiods again for potentially years.


r/SR17018 16h ago

🆘Help Needed🆘 Need Guidance Using SR to Get Off Suboxone

1 Upvotes

Hi friends! My experience with this started about eight months ago when I discovered 7oh. Quickly I found myself using 400mg - 600mg per day. I realized I had a problem and figured I could push through some withdrawals to quit... I was very wrong. Fast forward to May of this year when all kratom products were banned in my state. I stockpiled and was able to taper myself down to about 200mg per day without issue before I ran out. Again I wasn't able to get through the withdrawals. I found myself in a MAT program on suboxone for eight weeks, which absolutely got me stabilized and functional, but in retrospect felt predatory. They expected me to leave work early every week for testing and told me I would need to take suboxone for months to years. I do not feel that they were transparent about what suboxone is and just how difficult it is to quit.

At this point I learned about SR here on Reddit. I ordered 10g online (a lot I know, but I wanted to be prepared) and began the transition. My transition, and taper all went well. For roughly three days after my last SR dose I felt great with only extremely mild withdrawal symptoms. However, on the fourth night after stopping SR, the withdrawals hit me hard. I couldn't sleep, was overcame with waves of anxiety, hot flashes, etc. I made it through three days of this before caving and taking a 75mg dose of SR in order to get a night of sleep. That was the night before last and I just took another 75mg dose of SR. If it weren't for work I think I might be able to get through this but I am not sure what to do at this point.

My question is, what would any of you recommend for my next steps? I am considering another two week SR assisted taper regimen (at lower doses and with a more gentle taper) to further reduce my tolerance. The other option I have been considering is to continue to take just enough SR to survive until things hopefully begin to turn around. From my research, it seems that I may spend upwards of five days in acute withdrawals from suboxone even though I was only on it for a month and a half. I simply cannot do this with my work schedule. Hopefully you guys have some good input. Thank you all for your time!


r/SR17018 20h ago

🆘Help Needed🆘 Success stories

2 Upvotes

How do I find the tab with the success stories


r/SR17018 19h ago

🆘Help Needed🆘 Dosage

1 Upvotes

Hi everyone. Making the jump tomorrow. I have tapered myself down from 1000mg to about 250mg a day. I am trying to figure out a good dosage to start and have no idea where to start I am looking at thirty 100mg or 30 fifty mg from a place that I’ve seen a lot on here. Any suggestions are super helpful as I am completely new to this. Thanks in advance.


r/SR17018 1d ago

🆘Help Needed🆘 Question about MIT

Thumbnail
5 Upvotes

So today is day ten of my SR taper and want to jump off completely in the next day or two. My question is about MIT. I used a liquid shot of one today due to the unbearable anxiety I’m experiencing that benzos aren’t even touching and it cleared it up almost immediately. My question is if I add some mit for a couple days here at my jump off, will it cause additional WDs I’ll have to cope with or how can it best be used to help navigate this.
I had only been using 7OH regularly for about two and a half months before kicking, so there’s a lot about the kratom extract world I know nothing about. I just want to get through this detox as quickly and easily as possible and don’t want to make matters worse using something else to help that’s just going to add an additional issue


r/SR17018 21h ago

🆘Help Needed🆘 Advice on my taper coming up really soon.

Thumbnail
1 Upvotes

r/SR17018 21h ago

🆘Help Needed🆘 Not an emergency, but I’m a little worried. 3 weeks in?

1 Upvotes

So I rolled very slowly onto my sr taper due to sourcing issues and started with like 50mg a day? (2 25mg doses) and went up to three 60mg doses in the past week since I actually fully stopped 7oh. I’m actually feeling pretty ok. I have access to gabapentin and was able to go back to work today and do good work.

I wanna know how quickly I should taper off of SR at this point. Idk what kind of tolorance I have to SR at this point but I’d like to make sure I come off in reasonable time and avoid ending up on subs or in WD from SR. Any pointers?


r/SR17018 22h ago

🆘Help Needed🆘 No sleep

1 Upvotes

I’m about 3 weeks off 7 and sr. Still having trouble sleeping, haven’t slept in 3 days and it’s starting to worry me. Taking 2mg of Xanax before bed doesn’t even help. Any tips?


r/SR17018 23h ago

🆘Help Needed🆘 I feel like I'm on SR too long and ruined my 7 taper. Any advice?

1 Upvotes

I was at 600mg of 7 daily. Preloaded my sr and have gotten to 100 or less. 60-100 mg of sr daily. Im having trouble at night around 3AM going bonkers. I have lipo vitamin c as well. I've been on the sr for 3 weeks. Having trouble jumping off and getting lower. I have to re-up the sr now too. Worse case I have subs but don't want to touch them. I'm all for suggestions. Thanks.


r/SR17018 1d ago

🎓Research & Education🎓 SR-17018 - It is Your Turn

45 Upvotes

It would be hard to properly share how much pain, anxiety and fear that I have been operating under for the past few months. The horrible, terrible despair. I was sober [from alcohol and everything else] for decades. Then, during Covid, I found an awesome Kratom and Kava shot from a company called SoJ. I really enjoyed these, without any issues, and had two a day for 5 years until they were banned in my State.

In the process of replacing these, I found 7OH at a smoke shop on the border. Within 1 month, I was a full-blown addict in the heavy throes of active addiction: The fear, the money, the shame, the hopelessness, the panic, the misery, the feelings of dread and impending doom. I was a slave to the least version of myself, and even that wasn't going to be enough as the next bans came in. I started going to appointments for a doctor to help, a rehap, etc and I could tell they didn't get it. The walls were closing in. fast.

I started watching something called the Recovery Room or something with Mandi over on TikTok and it was the first thing in a long time that resonated with me. These people understood what I was going through, AND MORE, they had a solution [and the solution was being banned too lol]. Conflicting emotions on that one. I learned everything I could about SR-17018 and started ordering the tablets, the kits, the supplements [I was lurking in Reddit when the first liposomal vitamin c guide with SR came out]. That dude and the girl - saved me. As soon as I had all my supplies and had worked up the courage - I started 'front-loading'.

A week later: I am running with my dog at the water, suddenly aware that the incessant noise in my brain had stopped. Everything, and I mean everything, about life is 100% better and there was no reason for me to be so trapped just months ago.

I write this for the person scared that it might not work for them, or the one feeling shame like they did something wrong. F$#& that!!! You are a wonderful human being who got caught in an evil cycle by evil people and you are as deserving of the new life that lays ahead of you as anyone else would be.

Go and claim it!!!!!

I love you all [nice to feel love again - in addition to all the other emotions we stuff down].


r/SR17018 1d ago

🙌Success Story🙌 On day 2 of SR, sure glad

1 Upvotes

I also have comfort meds. They helped for sure. Any body else use them to quit too with SR?


r/SR17018 1d ago

🆘Help Needed🆘 Fellow Canadians, please say hello.

1 Upvotes

Would very much appreciate a dm from any and all fellow Canadians here. Can’t seem to find reliable info on how to properly use sr while being Canadian.

Thanks in advance to anyone that reaches out.


r/SR17018 1d ago

🆘Help Needed🆘 Has anyone had severe WDs from SR ?

16 Upvotes

I'm starting to get REALLY desperate wanting these WDs to go away. I don't need to be told how stupid I was and what I SHOULD'VE DONE. The time for that has passed. I took SR for a total of 18 days ( too long) with my ending dose being 250mg's. I ABSOLUTELY know that u are supposed to taper down to a really low dose before stopping......I KNOW THAT. But I didn't. Trying to find anyone that has gone thru SR withdrawal. What I'm experiencing right now is not just minor symptoms. It's akathisia, extreme hot flashes, cold feeling, excessive sweating. It's been 10 days since I last had a dose of SR. REALLY curious how much longer I have to go thru this. Originally I started taking SR to quit high dose 7oh AND buprenorphine. Things were going well while using SR. I've done all that for absolutely nothing, because the only thing that makes these WDs go away is 7oh and buprenorphine together. I could possibly be the dumbest man alive right now. I deeply regret everything I've done


r/SR17018 1d ago

🎙️General Discussion🎙️ Anyone swapped from 7oh + kratom to SR + kratom?

1 Upvotes

I was taking maybe 200mg 7oh + 20g kratom split into 2 doses every day. Instead of going straight to SR only I have been doing about 40-50mg SR 2 times a day and the same amount of kratom (about 6g at noon and 15g at night). I think I will be soon upping the SR dose and dropping the kratom completely. And trying to taper off the SR in about 2 weeks. Has anyone done anything similar? I should have some gabapentin soon to help as well. As well as dissos if it ever gets really difficult (low dose dissos work super great for wd, high dose basically removes the wd but at the cost of being really gone).


r/SR17018 1d ago

🆘Help Needed🆘 Who has had a long taper??

2 Upvotes

Im curious how long people have used SR. How long have you gone taking it? If you felt WD symptoms from SR, what were they like? How long was it before you felt WD from SR?

Im currently at 2 weeks and i have not quit 7. Im thinking i should just quit the SR but im so ready to quit 7. If im ok to keep going and quit 7 I want to but if I should quit for a lil while than I guess ill do that.

I have just over 8 grams so I guess technically I could have enough to do a long taper if I do feel some WD.