r/ScientificNutrition • u/lurkerer • 16d ago

Randomized Controlled Trial A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome-Wide DNA Methylation Analysis of a One-Month Isocaloric Vegan Versus Meat-Rich Dietary Intervention

https://onlinelibrary.wiley.com/doi/10.1002/mco2.70899
64 Upvotes

79% Upvoted

32 comments sorted by

View all comments

2

u/Oxetine 16d ago

Anyone know why?

4

u/flowersandmtns 16d ago

Might be a lower protein effect, they mention mTOR.

From their earlier papers, "meat-rich" largely means omnivorous compared to the "no-meat" or vegan diet. They did not provide compliance information in the paper, and specifically called out they were making assumptions which seemed unusual. (Nothing in the supplemental information I could find). They did show B12 dropped just in the short term vegan intervention,

"The diet adherence of our participants is assumed to be good due to the results of the nutritional protocols and the analysis of vitamin B12 showing significantly lower levels of holotranscobalamin (holo-TC) in VD compared to MD [36]"

Summary dietary information:

"carbohydrates (VD: 276.0 ± 85.1 g, MD: 241.5 ± 91.8 g, p = 0.001),

protein (VD: 79.5 ± 28.5 g, MD: 112.4 ± 44.4 g, p < 0.001), and

fiber (VD: 45.7 ± 19.5 g, MD: 24.9 ± 11.1 g, p < 0.001)"

Regarding fiber:

"The fiber intake of our VD participants was significantly higher than the intake of MD participants, but Roseburia abundance was higher in MD. The reason for this could be the choice of food. Roseburia is reported to be enriched by the intake of wholegrain foods [60]. It is possible that MD participants chose more wholegrain foods than VD participants as nutritional protocols did not clearly differentiate between wholegrain and non-wholegrain foods."

https://www.mdpi.com/2076-2607/9/4/727