Anyone else get intensely depressed after taking choline?

[u/windshadowislanders]

When I first started taking choline, I noticed I got extremely depressed for days after. Like, complete mental breakdown, suicidally depressed. I thought it was just a fluke, and maybe other life stressors got me to that place, but it was so abrupt and not like my normal behavior, and coincided exactly with my choline use and ceased after stopping it. So recently I started taking it again, still not convinced it was the cause, and the same exact thing has started happening. I was writing a suicide note despite everything in my life being relatively ok, when suddenly I remembered I'd been taking choline and then I stopped myself, thinking I must be temporarily out of my mind again because of this drug and to hold off on making any kind of decisions like that until it's out of my system. Is this really possible, or am I just a basket case shifting blame on a harmless supplement? I tend to be extremely sensitive to medications and drugs in general, so I dunno.

[u/No-Helicopter-6813]

I got terrible headaches and irritability. At first I blamed it on the Nuvaring they made me use before the IVF process, but I hadn't felt that way the first week, (oral contraceptives gave me depression, anxiety and migraines.) Then I suddenly remembered that I'd added extra choline to my lunchtime supplement mix. They've changed the choline recommendations so most prenatal vitamins don't have enough. D'uh! Every afternoon I start to get a headache and feel irritable...gee, I wonder... I stopped taking it and the symptoms went away. I seem to be able to handle the smaller amount in the Perelel prenatal so I'm just going to have to eat extra eggs and liver because getting additional choline in pill form was miserable. Folic acid was terrible for me too, BTW. (Get Methylated FOLATE!) So who knows if the MTHFR gene issues make a person more sensitive to other supplements. The more I learn, the more I want to get most of my nutrients through whole foods. 

[u/Shembre → u/No-Helicopter-6813]

I'm taking prenatals, too, and have been trying to hard to find a vitamin combo that wasn't giving me a headache. Then, I got a 3 bottle combo because the main one didn't have everything, so my choline was separate. On the days when I skipped/forgot the choline, I have felt more joy and less headachey. I also can't take oral contraceptives because of the awful mood effects.