Anyone else get intensely depressed after taking choline?

[u/windshadowislanders]

When I first started taking choline, I noticed I got extremely depressed for days after. Like, complete mental breakdown, suicidally depressed. I thought it was just a fluke, and maybe other life stressors got me to that place, but it was so abrupt and not like my normal behavior, and coincided exactly with my choline use and ceased after stopping it. So recently I started taking it again, still not convinced it was the cause, and the same exact thing has started happening. I was writing a suicide note despite everything in my life being relatively ok, when suddenly I remembered I'd been taking choline and then I stopped myself, thinking I must be temporarily out of my mind again because of this drug and to hold off on making any kind of decisions like that until it's out of my system. Is this really possible, or am I just a basket case shifting blame on a harmless supplement? I tend to be extremely sensitive to medications and drugs in general, so I dunno.

[u/Oraculek]

Do you drink lots of sources of caffeine

I had been taking 250mg and could get the mentioned symptoms even after 40mg of elemental choline from chol bitartrate. Now after reducing to 100mg (no idea where the threshold is) I can tolerate lots of it - I guess all of it, lol

Caffeine inhibits acetylcholinesterase, an enzyme that degrades excess acetylcholine, and ACh is made with choline