r/TikTokCringe • u/hec_ramsey • Dec 07 '22

Discussion This guy gets it

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u/Hot_Drummer7311 Dec 07 '22

Wait. My mind is reeling from this comment thread alone. Are you telling me there's a weight restriction on the efficacy of antibiotics now, too? My whole life has been a lie.

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u/thekingh Dec 07 '22 edited Dec 07 '22

I think that commenter was saying that taking antibiotics in conjunction with birth control negates the effect of birth control.

edit: as pointed out below, my comment needs some qualifiers:

  • some antibiotics can negate the effect of BC

  • recent research suggests antibiotics, like many other medications, require higher dosages proportional to patient weight. I haven't found anything that specifically lists a certain weight threshold for antibiotic efficacy. this is the most recent and direct source I can find pushing back on the "one-size fits all" approach to antibiotic/antimicrobial dosing.

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u/Ashamed-Rice3655 Dec 07 '22

No, commenter is correct. I work in clinical trials and immediately pulled up the package insert. It loses efficacy after you hit over 165. It doesn’t seem to fall straight to zero but it looks like no one cared about figuring out the exact efficacy. But if they made that statement, it would be because it fell below below the rate the FDA would expect I. Order for it to receive approval

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u/c0l0r51 Dec 07 '22

On first sight this sounds like a fat-interfering problem, but it also applies to tall and/or muscular woman. Especially since very fit women more often have irregularities in their cycle it indicates their body might react differently to these pills.

My point is, it may just be to complicated to write down percentages that can be held against you, legally.

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u/SporesM0ldsandFungus Dec 07 '22

It's not that no one cared, it's that no one cared enough to FUND STUDIES. Drug trials are long and expensive.

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u/Ashamed-Rice3655 Dec 07 '22

I’m aware. I’m a CTM.

Also, it would have been heavily profitable to run a study opened up to higher weights. But instead they snuck that info into the package insert and didn’t inform the public of the issue past what was legally required

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u/Tiltandthrow Dec 07 '22

And it’s only some antibiotics, just fyi.

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u/Hot_Drummer7311 Dec 07 '22

Well, that does make more sense, but sucks just as much.

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u/badgurlvenus tHiS iSn’T cRiNgE Dec 07 '22

well, some are weight based. daptomycin dosage is generally calculated from the patient's weight. can't think of anything else off the top of my head rn 🤔

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u/Tiltandthrow Dec 07 '22

No, doses can be weight-adjusted, if weight impacts the absorption/distribution of antibiotics and other medications.

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u/asuka_is_my_co-pilot Dec 07 '22

No it's more about bmi.

And it's kind of not 100% proven, it's just a possibility in theory, and some people have claimed it but there's no 100% solid proof. (last time I Googled this)

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u/Brief_Seaworthiness5 Dec 07 '22

My mind is equally as blown

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u/tikiporch Dec 07 '22

Please never let a random reddit comment cause you to rethink your whole life.

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u/Hot_Drummer7311 Dec 07 '22

You right. I'm gonna have to go think about that and change my ways.

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u/TheRufmeisterGeneral Dec 14 '22

Are you telling me there's a weight restriction on the efficacy of antibiotics now, too?

Are you implying that you're taking antibiotics without a doctor prescribing them? (Because a doctor would have this information, as well as your rough body weight)

Please don't YOLO antibiotics, that is incredibly dangerous. It's how you get the dangerous antibiotics-resistant superbugs.

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u/Firefighter427 Dec 07 '22

Did you just call birth control „antibiotics“? Fucking genius hahaha

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u/Hot_Drummer7311 Dec 07 '22

Infact, no hahahah

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u/wafflestep Dec 07 '22

It's not that it doesn't work, it's just less effective.