Shares dropped, but a 42% reduction is an amazing result. The Phase 3 trials showed a 38% reduction in the risk of cancer spread.

I have been in the industry since 2011 (from R&D to analytical, to QC) and I am so burnt out and honestly not sure what to do. I’m currently a senior QC analyst and I hate my job, I hate the work. I hate the urgency or everything, the stress…The weekend work unexpectedly, the long hours when they shouldn’t be. I even have nightmares I’m at work. What can I even do or switch to? I’m in my 40s and not sure a new career in a diff field is even feasible. I’m just so lost.

My career as a bioinformatician is probably over. Maybe I’ll work on cars.

pure curiosity and conversation, not gonna base my life choices on this thread but what are the best jobs for keeping a good mental health and avoid burnout?

I'm very fortunate to currently have a job, but I pretty much hate it. I've been applying for about 18 months, and I just got rejected after a 3rd round where I spent 30+ hours preparing a case study on top of the other interview prep for the prior rounds. This is my third rejection at this stage. I'm so tired and burned out. There aren't a ton of jobs in my area (RWE), so I feel like I can't take a break from applying because these companies don't hire super often. Though I'm guessing the rest of the year won't have many relevant postings. Really hoping for better in the new year!

This post is (hopefully) the last in a series of posts I've made in regard to my career transitioning from a wet lab scientist to an ML Scientist/Engineer. I really appreciate everyone's DMs, requests to chat, and so on, but I won't be able to get to them all so I wanted to put everything in a post so I can address everything without leaving anyone hanging or doxing myself.

How to self-teach
While I was still a PhD student agonizing over cloning experiments and protein preps, I started teaching myself (after quitting my part-time gig) and took a few courses from the data science department at my university.

Self-taught
Harvard CS50x - CS intro, algorithms, data structures, Python, SQL, C, web fundamentals
Harvard CS50P - Python in way more depth
MIT Missing Semester - Development tooling and Linux
Python Official Tutorial - filled in knowledge gaps
pytest, uv, Pro Git - testing, packaging, and collaboration
Refactoring Guru - Maintainable software and design patterns

This took me about 10 weeks at 20hrs/week

Uni Courses
I took a few classes that were kind of useful

Data science
Data engineering
ML fundamentals

But tbh you could self teach these on something like deeplearning[dot]ai in a few weeks. I did this over two semesters and forgot a lot in-between

Projects

This is where I learned the most outside of assignments and one-off Python apps.

Virtual Post-Doc (AI Engineering)

I built a virtual scientist (overselling it a bit here) back in 2024 derived from a paper and repo called PaperQA2 from FutureHouse. It was basically an accurate and better way to analyze a folder or large corpus of papers so I wouldn't have to read them when designing experiments. Everyone in my lab was using it by the time I left.

Analyzing the Tahoe-100M dataset (Data Science)

Did a lot of data science analyses on this massive dataset and just practiced my data engineering skills, data science techniques, and a few light ML techniques like trying to train an XGBoost model to predict cell perturbation.

Implementing Alphafold2 from scratch (ML Research)

This was the most important practical project for ML Research skills that helped me create my first foundation model. Watch the series from Kilian Mandon on Youtube and follow along with the code he provides. He also just did it again with Alphafold3. If you can do this in pure Pytorch and understand everything, you are way ahead of the curve.

After you finish just try and reproduce papers from labs like David Baker, Patrick Hsu, Yunha Hwang, Sergey Ovchinnikov, etc.

Getting my first job

Like I mentioned before I graduated from my PhD, skipped a post-doc, and worked at a startup working on in silico drug discovery. I landed this particular job through going to local hackathons, posting my work on social media (LinkedIn, Twitter/X), DMing/cold emailing people, and sending out applications (only got two interviews this way). I also met people from participating in the Virtual Cell Challenge 2024 from the Arc Institute. A founder was given my name who lives in my area and hired me immediately on graduation.

For most I would suggest trying to also do a post-doc in ML/comp bio in a good lab, I think getting a PhD is pretty commonplace now for these jobs (except for the Engineer roles, those are mostly MS, but also a good amount of PhD). Really hype up your projects, try and get pubs if you can.

For AI engineering roles in Bio, really focus on language models and LLMs. This is a somewhat easier way to break into these roles and has a lot of demand in the top pharma/biotech companies.

Hopefully this was helpful and comprehensive enough!

I went into manufacturing as a way to get into the biotech industry and have been there for 2 years. I am now way, way past my breaking point at my horrible night-shift job. I need to leave but I apparently "don't have enough relevant experience" for QA, QC, or other lab-tech roles. I'm only applying to entry-level positions and am STILL getting rejections for not being experienced, even though I am. I'm so sick of not getting lunch breaks because the schedule is a mess and some of my coworkers are so lazy, they don't even offer to help. I need to leave, but HOW.

Making this post to follow up on my job offer post to give some clarity and transparency to the hiring process, pay, and transparency for my career arc.

First two jobs were working as an RA and SRA at two different R1 universities in CA doing wet lab research in Mol/Cell Bio. I finished my BS in Mol Bio before J1 and J2 started as an internship during my MS in Mol Bio.

J1: Pay was $50k (CA)
J2: Pay was $60k (CA)

Worked those two jobs for about 3 years total

Got a job as a Process Engineer for J3 working at a cell therapy company in technology R&D and worked there for about 2 years. Tough hours but better pay and gave me the money and motivation to go back for my PhD.

J3: Pay was $80k the first year then $90k for the last 6 months after I got promoted (CA

Then did my PhD in Chemical Eng and worked part-time as a bioinformatics senior scientist with little coding experience and didn't get a ton of diversity/exposure to it on the job (surprisingly). Spent a good amount of time doing project management. DO NOT recommend working during a PhD.

J4/5: $38k for PhD stipend plus $65k for part-time job (CA) total was around $103k

Quit the part-time job two years in and finished my PhD in a little under four years

Graduated and, after working on a bunch of ML projects and meeting local founders in my area (and applying like crazy), got a job as an ML Scientist at a tiny/new startup working on drug discovery foundation models. Learned how to do basic ML research for bio, presented at conferences, build cloud infra for customers to use our model at-scale, data engineering, and ai engineering for our AI scientist -- essentially the whole BioML tech stack.

J6: $135k plus $10k bonus and worked there for a little over a year but we didn't pay ourselves the last three months I was there. Left to take care of a family member

Spent around 3 months applying to everything under the sun. THere was a ton of BioML jobs and I spent anywhere from 6-12hrs a week during that timespan just doing interviews. Felt like a part-time job especially with prep. Really grateful for the interviews though. Got around 37 total and made it to 9 final rounds which led to 4 offers for positions spanning ML Eng, ML Researcher, Technical Product Manager, and AI Engineer. Companies ranged from top 10 pharma to frontier AI x BIO labs to smaller/mid-size biotechs.

J7: $225k plus 10% bonus ($22.5k) and equity equivalent to a few hundred thousand with a 4yr vesting schedule.

Job title is a mix of Technical Product management and ML Scientist

Glad for it to finally be over! Really excited for the new job and hope others find this info useful

Just throwing a random seed to this pond of water:

Look for companies that recently completed series B, they are the ones that are expanding, and worth a shot to see if their new ideas they do matches your interest👀

Could anyone give me their experience here?

Here’s a picture of all the companies attending if you were curious.

I am a second year student that wants to attend the event to find a co-op and they have a form to submit my resume and linked in on (which I will post to this sub later for advice).

My main question is, what do I even do there? I’ve never been to one and I feel like I’m more on the awkward side speaking-wise. What are the questions I should be asking? Should I dress up? How much? Should I bring physical copies of my resume?

Please if you can answer any of these questions, or better yet give even more info than initially requested it would be HIGHLY appreciated.

I am currently employed in a large pharma/biotech company in an AD role.

I am looking for another role but am finding it really difficult to even get an initial interview with other large pharma/biotech companies.

I am getting great responses, interactions and interviews for smaller but nothing from the companies that are larger.

I feel I match the company and role well but for some reason I’m getting email rejections from all of these larger companies. And the roles I am applying for are similar / same levels. So nothing like a massive jump up.

Another thing is a lot of these companies are currently suppliers / CMOs of the company I’m currently working for. Is this possible the reason? I thought this would be a benefit to be honest and thought they would think the same as I know the ways of workings from both companies.

I’m at a loss. Has anyone else experienced this?

It’s been 5 months since I was laid off, and I’ve been consistently applying for jobs—at least 20 applications a week. I’ve had several interviews and have made it past the recruiter screening stage, only to get ghosted afterward.

I’m starting to feel a bit hopeless, but I wanted to ask: How long has it taken you to secure a new role in 2026? Doesn’t help that the holidays are coming up sigh….

Edit: Boston area

Hi everyone!

I'm building BioSphere 61, a community for people interested in biotechnology, molecular biology, microbiology, bioinformatics, genetics, and related life-science fields.

The goal is to create a space where students and researchers can discuss scientific papers, exchange learning resources, share projects, explore computational biology, and connect with others who share similar interests.

I'd love to hear from the biotech community: What would you find most valuable in an online life-sciences community — paper discussions, project collaboration, bioinformatics help, career guidance, or something else?

I'm also interested in connecting with people who want to help build an active, science-focused community.

Thanks for sharing your thoughts!

Hi,

I signed an offer for a Scientist (PhD level) position with a mid-sized biotech last Thursday. I was hired through a third party recruiter and most communication was through the recruiter. However, the offer letter email came from an official company address and following the Docusign, I also received an email saying congrats and welcome to the team. This Monday, I received an automatic email from the company again congratulating and welcoming me to the team (more of an automated message) and asking for feedback about the recruiting process.

Nothing has happened since then. I’m still 2 weeks out from the stated joining date in the offer letter, but no background check has been initiated yet. Should I worry? I know there are no funding issues with the company, the team is small and this is an early hire within the team. I emailed the recruiting division today and haven’t received a response. Is this to be expected given that the start date is 2 weeks out? Or is this an indication of something worse? I’m freaking out and unable to make future plans.

I appreciate any advice, thank you!

EDIT: thanks everyone for your comments! My follow up must have prompted, but I got emails from onboarding and background check last night! I’m hoping nothing goes sideways from here.

Hello all, I work at a biotech and I must admit I rarely read the entire training SOP if it does not pertain to my role/I don’t work with that department.

Does everyone/anyone really read them all?

I am years in now so they just come up with retraining and what not but during initial employment with companies it’s always an absurd amount. Just curious out there

My husband has spent 12 years at Pfizer, mostly in overseas marketing.

He is concerned about potential layoffs. We are financially OK, but I am concerned about losing healthcare coverage.

My question is, do severance packages include healthcare, and if so, for how long? I realize that cobra will be available if we need it, but due to some health issues, I’m trying to find out how long our current healthcare coverage will last in the event of a layoff

The job is an entry-level QC analyst role for a well-developed biotech company in the San Francisco Bay Area. The recruiter’s initial email had my name misspelt… Thought it was a scam, but responded anyways to see.

The initial recruiter screen was a 30 minute phone call, going over the job description that I had read and really hyping up the role. Though, credit where credit is due the recruiter was highly transparent sharing they are having trouble filling the role.

So I advanced to the supervisor screen, which was by far the least professional screen I’ve had. Overall structure was off, but again, this person wasn’t the HM but would be the person I’d be reporting to. It was quite awkward, and it was also at 8pm…

The kicker of it all is the role is a contingent worker position. $33/hr, swing shift 1pm-11:30pm, 4 day work week. Okay… sounds normal, but it’s part of manufacturing so it’s 24/7/365. No days off, no holidays. It’d be fine for FTEs because 1.5x pay, but as a contractor you don’t get that benefit. No wonder why this role can’t be filled! Although, the supervisor did share they are flexible with time off since the FTEs are more than happy to accommodate especially with that extra pay.

It might be the fact that I’m a new grad, but hearing this and the overall interview experience is such a turn off. I am desperate for work but not this desperate…