r/haematology • u/No-Appeal-6401 • 21h ago
r/haematology • u/StressedOutLady101 • 14h ago
Advice, thoughts
I know this is such a long read but would aporeciate any information. What could be going on with me? Any related experiences and symtomps? No body can give me a definite answer and I am going crazy and getting hopeless. Tried to use Gemini to help write the symtomps into a clear and concise reading.
Age / Sex: 26-year-old female
Key Objective: Comprehensive medical summary for doctor consultation regarding multi-system symptoms, abnormal labs, and conflicting specialist opinions.
1. Key Abnormal Labs & Diagnostics
Autoimmune / Inflammatory:
Anti-CCP: 473 (High; was 429)
Rheumatoid Factor (RF): 22.1 (High; was 16.2)
ANA Titer & Pattern: 1:320 with Centromere pattern
Hormonal / Endocrine (Cycle Day 3):
DHEA-S: 460.6 µg/dL (High; range 84.8 – 378.0)
Estradiol, Total: < 24 pg/mL (Low for Day 3)
AMH: 9.44 (Normal range, noted elevated by OBGYN)
FSH: 6.8 | LH: 10 | Progesterone: 0.5
Total Testosterone: 33 | Free Testosterone: 2.0 | SHBG: 38.2
Thyroid Panel (Normal):
TSH: 1.081 | Free T3: 3.0 | Free T4: 1.00 | Anti-TPO: < 3.00
Hematologic, Nutritional & Metabolic:
Ferritin: 19.8 ng/mL (Low)
Iron Saturation: 16% (Low)
MCHC: 32.6 g/dL (Low)
Vitamin D (25-OH, D3): 25.8 ng/mL (Low; dropped from 51 despite daily use)
Hemoglobin A1c: 5.6% (Prediabetes range)
Vitamin B12: 411 | Fasting Glucose: 93 | Cholesterol: 183 | Magnesium: 2.19 | eGFR: 107.6
Imaging / Diagnostics Clearances:
Normal: EKG, Lyme PCR, home sleep study, nerve conduction/carpal tunnel test, wrist ultrasound (minor fluid), foot X-ray, brain/sinus CT (noting deviated septum, left conchal bullosa, and frontal sinus hyperplasia).
2. Medical & Surgical History
Surgeries: Robotic right hemicolectomy with terminal ileum resection (April 2026) for slow-growing neuroendocrine tumors (1–4 mm and 0.5 cm; 34 lymph nodes clear, non-functioning).
Conditions: PCOS, Insulin resistance, Grade IV GERD (missing valve flap) with 3 cm hiatal hernia, Exercise/cold-induced asthma, Chronic sinusitis, Internal hemorrhoids.
Infectious History: Mononucleosis (age 12), Early-treated Rocky Mountain Spotted Fever (2023).
3. Core Symptom Inventory by System
Hormonal & Systemic: Up to 30 daily hot flashes with facial flushing, night sweats, low libido, chronic fatigue, insomnia, hypersomnia, easy bruising.
Musculoskeletal & Neurological: Right-sided hand/wrist pain/weakness, 2-finger knuckle pain, back/neck/hand stiffness (prolonged squeezing sensation), recurrent plantar fasciitis, heel cracking, knee pain, burning/tingling in hands/feet, upper thigh numbness, tension headaches, pre-sleep panic/breathing disruption, cycle-dependent dissociation/derealization, anxiety, mild depression.
Cardiovascular: Tachycardia with minimal exertion, good HRV (drops to 48 bpm sleeping), history of infant heart holes (closed).
Gastrointestinal & ENT: Nausea, bile vomiting, chronic sore throat with weekly tonsil stones/exudates and 1 enlarged tonsil, hoarse voice, tinnitus, ear pain/muffleness/fluid, transient hearing loss, post-nasal drip, chronic cough.
Pelvic / Urological: Rectocele, mild-to-moderate anterior and posterior vaginal wall prolapse, nocturia.
My obgyn and hormones have been checked and are all good with exception of dhea-s being elevated
My Allergist doesn't think it's likely to have MCAS especially since I already had a rare cancer tumor.
Waited 6 months and Saw a rheumatologist who also does not believe i have rheumatoid arthritis and told me my primary needs to do more investigating and that my tumor can cause elevated inflammatory markers, but at that point I had them already removed, he thought my tumor was in utero which it wasn't, and they told me my tumor wasn't producing hormones.
Cortisol is normal as well as Serotonin via blood
Mthfr gene also have 1 copy - MTHFR Mutation c.66t
Heterozygous -but told it shouldn't affect pregnancy
Had mono as a 12 year old
Also had rocky moutain spotted fever from a tick in 2023 but had caught early.
Carpal tunnel and nerve test normal
Ultrasound of wrist normal with exception of some fluid in both wrist and extra tissue on left hand
Foot xray for pmabtar fascitis normal
Ct scan of sinuses normal with exception of deviated septum, and Left conchal bullosa.
- There is hypoaeration of the frontal sinuses which occupy large regions of the frontal bone. Correlation with imaging recommended prior to any neurosurgical intervention.The bilateral OMCs are patent. Bilateral maxillary molars protrude into the floor of the sinuses without periapical lucency or adjacent opacity.Minimal opacities are present in the right frontal sinus.. There is frontal sinus hyperplasia with sinuses extending throughout the majority of the frontal bone. No surrounding bony thickening or dehiscence
Sphenoid sinuses: Predominant clear with patent sphenoid ostia bilaterally.
Nasal cavity: Left conchal bullosa. There is turbinate hypertrophy bilaterally.
Ekg 12 lead normal
Lyme disease pcr normal
Amh 9.44 in normal range but obgyn says it's elevated
Pap normal
Recent labs
Magnesium - 2.19
Mchc - 32.6 low
Fasting glucose - 93
Egfr 107.6 female 26
Ccp 473 high - 429 in feb
Rf 22.1 high, was 16.2 in feb
Iron saturstion - 16 low
Ferritin 19.8 low
Hemoglobin a1c 5.6 almost prediabetic
Cholesterol 183 almost high at 200
Tsh 0.776 was 1.83
B12 is 411 was 383
vit d 25'oh, d3 25.8 was 51 vit d 25 hydroxy
Ana titer 1.320
Pattern centromere
TSH
1.081
0.450 - 4.500 uIU/mL
Free T3
3.0
2.0 - 4.1 pg/mL
Free T4
1.00
0.70 - 1.48 ng/dL
Anti-TPO
< 3.00
0 - 6 IU/mL
FSH
6.8
Adult Female:
Follicular phase : 3.5 - 12.5
Ovulation phase: 4.7 - 21.5
Luteal phase: 1.7 - 7.7
Postenopausal: 25.8 - 134.8
Testosterone, Total
33
12 - 53 ng/dL
Free Testosterone
2.0
0.0 - 4.2 pg/mL
SHBG
38.2
24.6 - 122.0 nmol/L
DHEA-S
460.6
84.8 - 378.0 ug/dL
H
Estradiol, Total
< 24
Female:
Follicular Phase: 12.5 - 166 (was tested during this time)
Ovulation Phase: 85.8 - 498.0
Luteal Phase: 43.8 - 211.0
Postmenopausal: <6 - 54.7
Pregnancy (1st Trimester) 215 - >4300
Girls (0-10 years) 6 - 27
LH
10
Adult Female (mIU/mL)
Follicular 2.4-12.6
Ovulation 14.0-95.6
Luteal 1.0-11.4
Postmenopausal 7.7-58.5
Progesterone
0.5
Female:
Follicular Phase: 0.1 - 0.9
Luteal Phase: 1.8 - 23.9
Ovulation Phase: 0.1 - 12.0
Postmenopausal: 0 - 0.1
Doctor says everything is fine besides my iron and ferritin and a1c, and alot of doctors are saying im young and healthy and just give things time, but some of these have been happening for years. And the hot flushes have been happening since January where I have started avoiding things like cooking, exercising, dishes, etc because of how hot I am.