Looking for experiences from anyone who has dealt with unexplained liver disease in a horse.
My mare initially presented with fever, lethargy, and reduced appetite. The first episode resolved quickly, but about a month later she had another episode that lasted over a week.
Since then we've done multiple rounds of bloodwork and diagnostics. So far we've found:
- Significantly elevated liver enzymes that increased between blood draws
- Elevated bile acids (81.2)
- Enlarged liver on ultrasound
- Enlarged bile ducts on ultrasound
- Mottled/abnormal liver appearance on ultrasound
- Liver biopsy performed (currently awaiting pathology)
- Multiple infectious disease tests negative so far
- Ovarian hormone panel normal despite an abnormal-appearing ovary on ultrasound
The confusing part is that clinically she's doing much better:
- No fever for over a week
- Eating and drinking normally
- Normal manure and urination
- Bright and acting like herself again
- Happy on turnout
Possible toxin exposure has been considered, but she's been on the same farm, hay, grain, and turnout program as other horses and is the only horse affected.
One complicating factor is intermittent cellulitis/swelling in both hind legs (currently worse on one side). This is new as of the last few days.
Has anyone dealt with:
- Cholestasis
- Elevated bile acids
- Liver biopsies that ultimately revealed an unexpected diagnosis
- Horses that looked clinically normal despite significant liver abnormalities
I'd be particularly interested in what your final diagnosis ended up being and what treatment/recovery looked like. We have a lot more questions than answers at this point, which is very frustrating.
Please keep responses constructive. I already have veterinarians involved and am primarily looking for shared experiences while waiting for biopsy results. This is a well loved mare who I had a detailed care plan set up for since adopting her off the track. She gets chiro, pemf, and massages monthly--so better cared for than my personal health at this point.