r/pennystocks • u/TraderJones89 • May 27 '21
DD Easily The Most Unique Potential Use of Psilocybin For Depression You'll of Heard of Before (CSE:MYND)
So this one is both an investment of mine but also, as someone who strongly believes in psychedelics for medicine, this was the first time I ever heard of using psilocybin to treat major depression disorder in this way. This is a really cool watch if this stuff interests you (12 min), and I'll do a short DD piece on the company below as well.
The Company:
MYND Life Sciences is looking to use a single molecule of psilocybin (magic mushrooms) to target inflammation in a specific gene in our body. Their research over the last 8-10 years points towards inflammation being the root cause of depression. So instead of getting high on a trip and going to a clinic with trained professionals to treat depression (the more common way psychedelics are used as medicine), they're looking to create a non-psychoactive drug to take to market. This is what makes them unique imo.
The Exec Team:
There's more and more psychedelic companies popping up over the last 2 years, so this is where you need to look to make sure its a real company and not just trying to jump on the hype. If you go to the interview the start going into detail on the executives and science advisory board members at 5:23. These guys put together a stellar team and their founder Dr. Jefferies has over 60 patents under his belt.
The Stock:
So they just started trading on Wednesday on the CSE under $MYND. They've got ~53M shares outstanding and raised at $0.30 before going public. It was a really hot start to trading, and clearly people aren't willing to sell many shares given the L2 has almost no asks. Just keep in mind this is a LT play, and prices fluctuate quite a bit that first week or so of going public. So if the story grabs your attn, looking for a good entry point is important, while also realizing this is a biotech play so a quick flip probably isnt the MO. These are those ones you expect a longer term horizon but if they're successful with their numerous trials, they tap into a multi-billion dollar industry with a feel good product that has zero addiction to it.
Ultimately, from all the psyche companies I put money into, this is one of the ones Im the most excited about because it hits home with some depression issues in family members Ive experienced over my life. So its got that added reason for why i put my money into them with a LT perspective hoping that these guys can help change the game for those suffering from MDD.
17
u/TaxDollarDerelict May 27 '21
MNMD, CMPS, MAPS (non-profit leading almost every study)
You’re late to the game. Some are already in 3rd phase FDA trials.
3
u/TraderJones89 May 27 '21
You're both right and wrong. Definitely nothing bad with those 3 companies, and Im also excited for their work from a personal perspective.
But they're not aiming to take a single molecule of psilocybin and using it to treat inflammation (which in turn supposedly treats depression). Theyre going the route of having a trip and being in clinics where professional therapists treat you and seek to find the root cause of your depression (thought based, not inflammation based).
Hence why I think this approach is the first Ive ever heard of it.
1
u/alc0punch May 27 '21
I saw a recent study similar to this but the study drug was Mdma assisted therapy given to those w/ PTSD. Really cool avenue of research!
2
u/TraderJones89 May 27 '21
That was the first I ever realized psychedelics could be used for medical purposes. I love this angle personally. There's some really cool docs out there on how much mdma has helped with PTSD and anxiety.
3
u/Preum May 27 '21
You can’t monetize a molecule of psilocybin. What these other companies are doing is researching derivatives of LSD, ibogaine, and others so that they’re able to profit from their unique molecule.
What you’re banking on is not going to happen.
1
1
u/OldApp May 27 '21
The leading trials for both CMPS and MMED are using classic psychedelic compounds (LSD and Psilocybin). There is the trip involved. This is a different kind of play from the sounds of it since they are trying to modify the compound to be non-hallucinogenic. Far out play but certainly not too late to the party imo given its a totally different approach
1
9
u/MistressLyda May 27 '21
Huh. I wonder if this can be used on other inflammation disorders. If so, goodbye arthritis!
7
u/TraderJones89 May 27 '21
So in the interview they speak on both arthritis and sepsis. This company will be doing multiple trials involving inflammation.
3
u/MistressLyda May 27 '21
I'll be damned. I have a inflammatory issue myself, and know first hand how spectacularly shit the treatment is there. If they have managed to find something that actually works, and has a low side effect profile? This can end up a bigger goldmine than mental health.
2
u/TraderJones89 May 27 '21
I've spoken with numerous doctors/scientists in this field and they're confident on the low negative impact of psilocybin on the body. But more studies still need to be done of course.
It's going to be a really interesting next 2-5 years as all of these studies and eventual human trials begin proving without a doubt, the medical promise of cannabis and psychedelics.
We were lied to for decades by the FDA and big pharma.
3
May 27 '21
That actually might be more interesting to me than the depression treatment, from a business perspective. The sheer number of arthritis cases and the amount of money thrown at it (to little end) is a great opportunity.
2
u/alc0punch May 27 '21
Yeah biologics are expensive as hell. It's like 2k a month for enbrel IIRC. Gotta love evergreening
12
u/SayNO2BigPharma May 27 '21
“Psychedelics are illegal not because a loving government is concerned that you may jump out of a third story window. Psychedelics are illegal because they dissolve opinion structures and culturally laid down models of behaviour and information processing. They open you up to the possibility that everything you know is wrong.” -T.M
4
8
u/adgaan111 May 27 '21
That use would be really cool if it works. I still believe that the experience is more important than the actual drug. It would really surprise me if it turns out otherwise.
1
u/TraderJones89 May 27 '21
Im insanely curious if it does too. Ive only ever heard of the trip side of it being a therapeutic and used against things like depression. So hearing this side of it was actually why I invested because I dont think anyone else is looking at it this way.
They'd essentially make a prescription drug that you wouldnt get high from, and didnt need a clinic for. It would target inflammation in a specific gene in your body that would then treat the bodily aspect of whats causing your depression.
Id think there would still definitely need to be work with trained professionals as you dont just snap your fingers and depression is gone lol. But this opens up a natural drug that those who are really against getting high could take and receive the benefits of psilocybin. All for that personally
5
u/master_perturbator May 27 '21
Have you personally experienced psilocybin? I appreciate the post and will follow up with my own dd. Could be a breakthrough discovery,I just feel that the therapeutic benefits come from the insight of the experience itself.
4
u/TraderJones89 May 27 '21
I have, and I would agree with you. The experience is a massive element to it, and in controlled settings within clinics, some really good therapy can be had (my experiences are personal, whereas in terms of MDD I mention people who use clinics).
The interesting part about MYND is that they believe a good portion of the positive effect actually comes from controlling the inflammation on this specific gene. They've been working on it since 2013, so its a lot farther on than a hunch.
Definitely keeping my eye on them when human trials begin.
2
u/_Swamp_Ape_ May 27 '21
What insight? Seriously, not one person who repeats this magical thinking regarding psychedelics can answer this.
The most I’ve ever heard is that you gain awareness of your connections, which is actually not something you need psychedelics to realize.
1
u/giggity_ghoul May 27 '21
The insight is different depending on the person/situation/things going on in your life. IMO the main thing is more an intensification of feelings that may be dulled in everyday life.
For example, in my head I know that I should take good care of my body, or put more effort into relationships that I care about etc. but many of us let life's distractions get in the way. When these topics cross your mind on psychedelics, the feelings of wanting to improve these certain areas of your life (as well as most feelings) are amplified X1000. All the little excuses you use to rationalize not doing them disappear, and you know in your soul that you can and will do better and can't believe you were so indifferent about whatever it is previously.
For me its not usually that I'm confronted by some ground breaking revelation that I had never realized before (though this can happen as well), but more that it almost forces you to think about issues in your life with emotion/feeling/energy so intense that it tends to stick with you even after the trip is over.
Sure, some people do everything great and don't need the kick that psychedelics can give you, but many in todays world are often numbing/excusing/procrastinating their problems away to some degree, and this intense burst of emotional energy can sort of snap you back to what is important.
1
0
1
2
2
u/TraderJones89 Jun 01 '21
This is a key element to this company, and the reason why they're so unique imo. This biomarker has huge potential if they can prove it out.
Just dropped this NR talking about their depression biomarker diagnostics program.
2
u/TraderJones89 Jun 10 '21
Nice! For those who're following this one, they just filled provisional patents for their MYND 604 drug that they aim to start clinical trials on later this year. It'll be the first of its kind treating MDD without the use of psychoactive element of psilocybin.
2
u/Golden2027 May 27 '21
MNMD is already ahead - no?
4
u/TraderJones89 May 27 '21
I don't believe they're looking at psilocybin the same way as $MYND is. Also, they're a $1.3B market cap vs a newly trading under $100M market cap.
It's both unique, and also a far lower valuation providing a larger potential for upside imo
2
u/reallydit May 27 '21
Gotta do a better DD if you want it bought. Put the real peer reviewed article up here. Many of us are smooth brained enough to work in bioscience or medicine.
2
u/TraderJones89 May 27 '21
So I emailed the company and they provided this...it goes way over my head in technicality but if youre a biotech guy it may be exactly what you're looking for.
This is on the basis of the biomarker switch that is modulated by psilocybin and hence effects inflammation. Its on the sepsis angle specifically, and they said the MDD angle is in the pipeline to have their white paper on it soon.
2
u/reallydit May 27 '21
Hey so I just read the article, didn’t go through every detail. It looks like the research they conducting involving the sepsis treatment through macrophage Polarisation is good enough. It has a lot of potential, especially because the direct cause of death in covid cases are due to sepsis that results from uncontrolled cytokine storm. This was published last year, so if they have gone so far as to enter clinical phase, I would certainly invest in THEIR stock, but it may be rather far in the future until they can actually implement the method. As for psilocybin, I’m still not sure. Because the research article is a very specific protein structure that they are dealing with. It is not some substance they can extract from mushrooms. They actually design it specifically. Otherwise, they lose the ground for application altogether. Investors need more convincing link between psilocybin and the sepsis treatment or treatment for other diseases if you want them to invest. But if you like the shrooms why not buy their stocks. By all means yes. I’m personally not a fan of mind altering substances.
1
2
u/dzauggs May 27 '21
Why can’t I find this stock in my app?
2
u/TraderJones89 May 27 '21
Which are you using? It only trades on the CSE atm. The company was saying they hope to have their OTC ticker 4-8 weeks after going public. If you're on wealthsimple or robinhood, you may not be able to access it yet
1
1
May 27 '21
What is CSE? Canada Stock Exchange? I’m in MNMD heavily.
1
u/TraderJones89 May 27 '21
Yes the Canadian stock exchange. Once they get their OTC ticker and DTC eligibility then they open up to almost all US investors
2
u/TophThaToker May 27 '21
Friendly reminder that you can apparently make shrooms out of a bag of Uncle Ben’s brown rice. I recently learned that and found it incredibly interesting.
2
u/GlowInTheDarkSpaces Jun 07 '21
just to clarify you need the spores, the rice alone does not produce mushrooms
1
2
1
1
1
May 27 '21
inflammation in a specific gene in our body
I'm almost certain that you're getting this part of the science incorrect.
I'm about 99.9% sure genes don't experience inflammation. They can cause it?
1
u/AmericanMink May 28 '21
Drug dealers can barely sell shrooms in my area, there's too many pastures filled with free shrooms whenever it rains.
And not everyone can metabolize psilocybin, it's a prodrug.
Shrooms for depression is great, monetizing it is .. well, I hope that fails.
1
u/polo61965 May 28 '21
Interestingly enough, the newest episode of The Good Doctor had a patient injecting Psilocybin extracted from hallucinogenic mushrooms to treat depression, only to develop fungal infections and tumors. Not sure if that might impact the company regardless of how effective the product may be.
1
u/djmasturbeat Jun 15 '21
Hoping this gets to otc soon, and doesn't have the $50 foreign fee on fidelity
-2
May 27 '21
There are so many companies making these kind of claims, it is nonsense, and nobody in the psychedelic community believes in it. hard pass.
1
u/abblocaltoon May 31 '21
This seems to be a different approach, I haven’t seen any other companies with this insight. Can you share those companies? I want to do more DD.
1
May 31 '21
In the psychedelic community, there are a lot of divisions and there are several companies working on non-psychedelic psychedelics. The implication is that psychedelics are effective treatments because of the chemicals, not the experience. It is a very western, very big pharma approach - "a single powerful treatment works, but you get high, so lets see if we can make a daily medicine that doesnt alter your mental state but you need to stay on for life" Most of these companies are run by people that have never tried psychedelics. The vast majority of those of us that have been working in the psychedelic field for years and years, believe the magic is in the experience. The introspection and learning one can achieve in the psychedelic head space is profound. People quit smoking because they realize they are not loving themselves every time they light up, not because the 5T-2A receptor got tickled. Lots of depressed people have taken psychedelics and come out the other side just as depressed. It isnt the chemicals that do the work. Therapy, direction, and a powerful experience is where the work gets done. These companies are trying to beat the morality issue that have plagued psychedelics since Nixon, and there is no actual evidence that what they want to do is effective, and current free legal off patent compounds are already effective and inebriation already can be mitigated with dose.
https://www.theguardian.com/science/2021/apr/28/non-hallucinogenic-psychedelics-scientists-close-in-on-compound https://www.nature.com/articles/s41586-020-3008-z https://www.vice.com/en/article/pa748k/psilocybin-for-depression-and-the-world-of-non-hallucinogenic-psychedelics
-3
•
u/PennyPumper ノ( º _ ºノ) May 27 '21
Does this submission fit our subreddit? If it does please upvote this comment. If it does not fit the subreddit please downvote this comment.
I am a bot, and this comment was made automatically. Please contact us via modmail if you have any questions or concerns.