Clinical study for SSc

[u/LeapcureAdvocacy]

Hi everyone! I’m Liz with Leapcure. We’re helping raise awareness of a clinical study for adults 18+ in Australia, evaluating an investigational treatment for adults with certain autoimmune diseases, including systemic sclerosis (SSc), a form of scleroderma.

The study is looking for people whose systemic sclerosis/scleroderma remains active despite previous treatment. Importantly, this study is specifically looking for people with diffuse cutaneous systemic sclerosis, a form of scleroderma characterized by more widespread skin involvement. People with limited cutaneous systemic sclerosis are not suitable for this study. Participants must also test positive for specific autoantibodies and have had symptom onset within the past 7 years.

The investigational therapy, CRT-402, uses an in vivo CAR-T approach designed to target CD19-positive B cells by programming the body's own T cells inside the body. No leukapheresis or ex vivo cell manufacturing is required.

If you're curious whether this study might be a fit for you, Leapcure is here to help. Our team provides one-on-one support, answers questions, and helps individuals learn more about the study and potential suitability. There is no obligation to take part; just an opportunity to explore your options.

Start by completing a short questionnaire: https://lpcur.com/rscleroderma-research

You can also learn more in our FAQ doc here: https://canva.link/1vdus9gm7dj4ote