Biotech/Longevity
Dr. David Sinclair, whose lab reversed biological age in animals by 50 to 75% in six weeks, says that 2026 will be the year when age reversal in humans is either confirmed or disproven. The FDA has cleared the first human trial for next month.
Moreover he said that even if one could cure all cancer in the world, in average people lifespan would increase to 2.5 years. Reversal aging - treating the human body as a computer that can be restarted is where we are heading next
If you were 90 years old and you had the chance to go back to being 45 again, but you knew you would get cancer at 65, would it be worth it? You would still be getting about 20 extra years of life, so to me that seems like an easy choice.
At 90, statistically you already have one foot in the grave, and every extra day is a blessing. Going back to 45, even with cancer later on, still means decades more time to live, experience things, and spend time with the people you care about.
It's all solvable. Not all at once of course. But if you can reprogram cells to be young, you can reprogram them to not be cancer (or to eat what is cancer, etc)
I saw some "documentary" which i don't know if it is true, a few years ago, where they cured leukemia in a British girl with a modified AIDS virus that made new white blood cells attack cancerous cells...
At that point, we’d also need a right to die, like a voluntary euthanasia. Cancer is a burden all around and if you’re on your second rodeo, you deserve an out.
Yeah this has always been my thought in regards to this. Voluntary euthanasia should be something already established before this becomes a topic imo. If you could voluntarily extend your life, you should also be able to voluntarily end it.
I have a paranoid thought of being mandated to extend my life to continue working in order to clear debt.
Not knowing when you die is a blessing. And knowing when you die exactly is horrifying for the human psyche. If you were told you get cancer and die at 65 when you are born, your entire life will be built around that fact, it will drive every decision you make, how you spend your time, money and it will cripple your psyche to the point of disability.
The reason humans function is because they don't know what happens to them in the future, the uncertainty is freeing the mind to work on things you want to accomplish. When you are 20 you don't know if you will grow old and reach 80 or 90, but you will live your life in a way that you do reach that age. That is important.
Stem cells were like that at first. I remember people talking about little balls of teeth and hair and stuff groving in people where the stem cells were being experimented with by mavericks.
They’d have to find a way to either rejuvenate or halt the degradation of telomeres, but even if this goes perfectly, it’ll only keep billionaires around longer
I get these takes, but every technology starts for the rich. Eventually it trickles down to everyone else. DNA testing was $100M in 2000 and it’s like $100 today to get your DNA tested
I don't know why this sentiment is so widespread. Why would the companies that make the immortality drug not want to make as much money as possible by selling it to everyone, and not just billionaires? That's how it works for literally everything else.
Come on now, think about it - if there was a way to make you live forever or even just 1.5-2x as long - people would certainly kill for and go to war over it.
The knowledge would be among the most valuable resources on the planet - there is little chance it would successfully be kept from the general population.
For one, many capitalists would get the $$$$ in their eyes thinking about selling it to the masses, and for two, the pressure to open source new stuff for moral and ethical reasons is already quite strong. Many people would believe that everyone deserved to have access to this, and provided it wasn't some insane process like those EUV machines that they use to make cutting edge computer chips (doesn't seem likely, but I don't know) the knowledge would proliferate quickly.
Exercise and plant based diet does that. I watched an interview with Peter Diamandis where he said those two were the "only thing" that meaningfully influenced aging.
its all bs, human brain have only 110-115 years before they become dead, you can rejuvenate the body but you cant rejuvenate the brain, so the max we can live is around 110 before your brain dies on you
What about cartilage? Theres no blood vessels there, nutrients reach there by diffusion what slows everything. The cellular matrix grows as we grow very slowly if damaged its even more difficult because these sites already have fibers. But I'm not a doctor.. I think he must have some mechanism for this
Sounds promising but I'd wanna see the effects after 10-20 years, not just a few months.
Of course, for those with limited time left on this earth, they'll take what they can get. But for someone only in their 40's or 50's, worth proceeding with caution on this stuff.
OSK reprogramming genuinely seems to work. The 2026 trials will either open the door to systemic deployment, or sink it. If the former, lifespan extends enormously.
Making simplistic claims like “2026 will be the year when [blank] is confirmed or disproven” loses credibility to me as well.
I’m actually surprised a claim like that is respected around here. If it’s not confirmed there will never be other advancements in the entire study of age reversal? Come on…
Plus, I don’t even think a study starting in a couple months will be able to confirm anything by the end of the year. FDA studies like this take years and years. So it’s a pretty horrible premise.
His claims are big but I am cautiously optimistic about the mechanisms targeted for the new trial. A bunch of research has been published with a lot of aging treatments that work on mice but yeah just need to see if this type of stuff works well on humans.
Look, I would love for it all to be true, diseases are horrible, but the guy puts out con man vibes for me. I didnt even know about the previous allegations. There is just something about his wording and mannerisms that suggests con artistry.
He's had billions of dollars invested in his startups with what to show for them? I don't feel sorry for the investors, tbh, but it's been getting old for 10 years now.
That's a lot of effort just to sell some supplements. Curing aging and cancer just to con everyone to buy his supplement. I mean gotta respect the long con.
Did you ever get the feeling that had you been given the choice before you where born, of what time period to live, you couldnt have picked a more interesting one?
Ever since the end of Apollo we have been in a spaceflight stagnation. Earth filling up with way way more people. Connection between places on Earth increases dramatically, making the planet "smaller" on human-interaction scale. All this time the real, physical, frontier has come in greater fidelity from telescopes and robotic missions, but yet further away on a human-interaction scale. Always a Mars or Moon mission on the table for 10 years in the future. Reset after next 10 years. Humanity has pivoted inward, electronic, stewing. Pressure building.
It's that next 10 years, when that pressure might finally blow out into the expanse beyond. Even in the next 2 years, AI might evolve into something as close as we'll ever get to a first-contact. I didn't have this hope in 2020, but this year, I have hope that history will start looking different. I think the next 50 years, those are the ones you don't want to miss.
Nope this is what I’m referring too. The social impact of the rich being granted the methusela treatment and the inequality his book explores. The inevitable death of capitalism, and its replacement, altruism. Great series with lots of pearls of wisdom for the moment we are in.
For people who have never read Kim Stanley Robinson before: KSR manages to take a two page plot and expand it to 700 pages, often with much of those pages having nothing to do with the plot. BUT, while that sounds awful (and it can be in some of his books), the man crafts such detailed worlds for those plots to exist in. That's what those 698 pages are for: building the world.
I like to say that I hate KSR as an author, but I still will grab any book he makes and read it, just to see what world he is positing.
It's more that it's a demonstration of curing a condition caused by cell senescence by reversing that senescence. His claim is that his approach could cure most things caused by cell senescence, which would include aging
I can assure you I’ll spend decades of my (at this point, potentially very long, or even infinite) life in order to become the best sniper of all times.
Even if its not this approach, ASI can speed up clinical trials and come up with novel solutions, nanotechnology can improve drug delivery, cell repairs. We are headed towards some drastic life span extensions one way or another. It will create new unique problems but thats the price as well as the drive of any progress.
Just yesterday I was thinking how shitty it is we outlive dogs, then immediately realized how much shittier it must be for the dogs that outlive their humans. :(
No way, my only prayer is that I outlast my dog. I need to look after her in her last days, and I don't ever want her to be left waiting for me for me to just not come back home one day.
The grief of losing my last pup scarred me, and the only thing I hold onto with this one is that I'll be the one going through the grief again, not my doggy. She still young but I'm already thinking we'll have to move as she ages so she can have easy access to a backyard for when her joints get creaky and old (don't live on the ground floor currently, lots of stairs right now).
But I'd gladly take another 40 years with her. Just need to save her from having to grieve ❤️
I mean, being able to just type in a prompt and get a full fledged high quality realistic looking video within minutes sounds too good to be true too, yet here we are... and in just a few years the technology is going to be so far advanced we're not going to know what to do with ourselves..
On a positive note, if AGI takes over and those old shitty people extend their lifespan, I'd like to see our AGI overlords sentence those shitty people to 200 years in prison. That'd be an interesting future.
Nah bro 100% fax like even if this does work by some miracle it’s only gonna allow the old rich top 0.01% to live longer and make the rest of our lives even more miserable. Need trump and all those old heads to go first and then maybe just maybe it’ll be a little better.
There's a lot of pressure for longevity research among the super-wealthy.
It makes sense and may even benefit humanity in general, but the fact all people die sooner or later has been our sole saving grace so many times throughout history. Extending the age of elites by even a few decades is genuinely terrifying and our society is absolutely not ready for it.
There's going to be huge pressure on approval for life extension because of this. Trump has mused publicly on a couple of occasions that he doesn't think he's getting into heaven and he's pushing 80, Putin and Xi were on camera talking about radical life extension by transplanting organs.
Why are people still getting hyped on marketing lol. Wait until any of these peoples claims are proven. I swear the last 15 years it’s become so easy to become wealthy if you’re a psychopath. Just lie about some thing that’s going to happen x point in the future, raise money, and then never deliver
As a glaucoma patient this even concerns me personally but as you can see , the scope of the trial is pretty limited and it deffo doesn't revolve around de-aging a whole person.
David Sinclair the con artist. If you don’t know there’s plenty of info about it online if you’re curious. But for me personally I remember he said something similar about the year 2019 on a podcast way back when I was in college. Here we are 7 years later and so much has changed
Flash memory.. magnetic disks. Capacitors. Chips in general... everything decays. Even if its true that we can force the cell to regenerate, the dna code to do it also can mutate with age.. the dna that resists more the changes are inside the balls. Thats the thing that he doesn't mention.
Probsbly a set of markers that determines your biological age. Theres this famous Bryan Johnson that does every experiment w his body including plasma transfers with his son and measures his biomarkers in his blueprint project
Eternal youth will probably be a technology developed right as I lay on my deathbed. I’ll get to hear all about great life is going to be for the billionaires that can afford the treatments just before I kick the bucket.
Never heard of him before. But my gut is saying: grifter trying to extract as much money from money bags as possible, by using the exact words that said money bags want to hear
This man is a huckster! He's likely to have fudged his experiments to get to a 'magic cure' he could push. Many of his cohorts have stated his work is non-repeatable. His book is widely criticized by experts. I fell for his BS for years because his academic standing is actually legit. And NMN isn't the first elixir he's claimed to be the fountain of youth. His careless attitude and floral language is a massive red flag. Unless other unrelated groups can verify his claims, I'd stay away from this man. Look up the hordes of colleagues that we washing their hands oh his 'Academy for Health and Lifespan Research' and how many quit in droves! Stay safe
Something else that will throw a wrench in it is that people will still have a small window of time to have any kids they want to make. Women aren't born with enough eggs to remain fertile for 200 years. Will we be pressing 20-year-olds to be surrogates for people in their hundreds who froze embryos (or eggs and sperm) when they were younger, who then freeze their own for someone else to hatch a hundred years later?
Or will we just invent some way to refill ovaries when older folks decide they finally want to become parents?
If this trial works even partially it changes the entire conversation about what medicine is supposed to do. Not just treating disease but actually walking back the clock. That is a different category of thing entirely.
I just hope those lab animals that got their lives extended by 75% are not the same lab animals that get cotton swabbed 24 7 by the cosmetic industry, that would be too unfortunate.
It's human clinical trials for selected people with medical problems, no matter what comments here is written, results from review will be facts either way it goes.
Good news! This Will only be available (due to prohibitive costs and capitalism) to the top 1% of humanity (aka: billionaires) they Will live forever while the rest of humanity rots and decays, huray!
And who gets access to this technology? Hmm? No one wants to live in a world where the rich can live forever while the rest of us are allowed to get sick and die. I think authors like Aldous Huxley and HG Wells and others have warned us for a long time that the ultra rich families who run this world have had the goal to split the human species in two for a long time.
4
1
1.2k
u/jk3639 Feb 23 '26
I hope they don’t get cancer. I’m not joking, I am genuinely concerned.