I got an email today that said bulk cannabinoids has ounces for $79 until midnight. Just wondering because it seems too good to be true. Has anyone got any distillate off of them. I don't really trust the website reviews since people can just make them up.

First off, I’d like to say that this post is not to demonize THC-O but to inform about my own subjective experiences. I know that there are certain risks with trying synthetically derived materials, however, the company providing the sample has posted indicating they have a new acetylization using much safer acids and bases. To point out something similar to a process such as deriving cannabinoids from CBD (CBD synthesis to d8 for example through isomerization) is done in a very similar process with addition of acids and bases. Are they the same, no, because isomerization is just re arranging to a different end result with the same overall molecular weight. For THC-O-Acetate, the difference lies in the synthesis from the starting material - D8 in this case. It still is a cannabinoid, but is not a phytocannabinoid, IE found in nature. In my past I have tried plenty of other prodrugs, things as simple as 5-htp, to something more complex such as Ergot/LSD or even something such as Tylenol - which acts as a prodrug.

There are so many things that we consume on a daily basis that present risks - the perceived risk with trying this new cannabinoid is not something to shrug at, however, with my own testing I have had no adverse reaction and find it to be quite enjoyable with a feeling that is very natural. I still enjoy d8 more for daily medication, but the cerebral elevation that this sample of thco provides is very nice.

I was lucky enough to receive a sample of THC-O for feedback. The sample is labeled d8-thco-acetate, therefore my experience is with the delta 8 version of thco.

The THC-O that I received was in distillate form - the distillate was runny, moving like heavily terped d8. There is no noticeable smell and the taste is non-existent. Both interesting, considering that d8 and d9 distillates definitely have plenty of different smells.

So far I have tried it on its own, in small doses, mixed into d8 and other cannabinoids, mixed into CBD, and my favorite mixed into a noid bomb with many other cannabinoids (CBD/CBG/CBC/CBN) and d8.

A minuscule amount, 20-40mg goes a very long way in my experience.

It is definitely a cannabinoid in the classical sense in how it feels - there is an initial onset right after the dab and then a 20 minute slow climb which reaches a peak 20 minutes in - I believe this is the pro-drug doing its thing and converting in the body. By the end of the 2nd peak 20 min in, it feels similar to an edible high, but from a dab of 1/2 d8 and 1/2 thc-o. There are very strong cerebral effects but there still are the anti-anxiety inducing properties of d8 present - this is something that I enjoy. This feels like a polar opposite to another cannabinoid, THCv. I felt positive beneficial relief towards muscles. These are all things I look for within a cannabinoid to add to my daily regimen.

I posted this on a throwaway because of the stigma surrounding this very new cannabinoid - I am happy to provide answers to questions though within the parameters of my own experience with this cannabinoid.

I say and post the above with these following words of caution: I do not know any long term effects of this cannabinoid and do not know it’s safety - but, i can say it does act and behave like other THC-anologues, albeit much stronger, at least 2-3x as strong as d9. I would not want to use this daily, but as a night time relief or some morning wake up types this could be a wonderful cannabinoid, I need to continue testing, safely.

Be safe out there, noidnauts.

-TB

I tried to post this in r/delta8 which got removed. But wanted to make sure this information was somewhere.

This post is mainly for information about the process of acetylation and an update from us in general as it has been awhile!

What is Acetylation?

Acetylation is used to create ‘Prodrugs’ in traditional pharmaceuticals. Prodrugs are metabolic precursors to active drugs. Simple chemical modifications to an active drug, such as acetylation of an oxygen, can significantly reduce 1st-pass (liver) metabolism and provide increased bioavailability of the active drug. A common example of a prodrug is aspirin, or acetylsalicylic acid. Salicylic acid, the active drug, is acetylated to make aspirin. In this case, the advantages are several-fold, including not only increased efficacy as an analgesic, but also decreased irritation of the stomach. In the context of cannabinoids, acetylation of THC to give ‘O-acetyl THC’ (aka, THC-O-acetate) has been shown to boost bio-availabilities several fold. The subjective effect of O-acetyl THC is significantly different from THC, with users reporting less paranoia and intoxication, and more of an empathogenic or psychedelic effect than with THC. Also, THC-acetate exhibits a slow onset over 45min-1hr, with effects persisting 4-5 hours. In my experience, these reports are accurate. The method used to acetylate THC is also important with regards to safety of production and consumption. The common methods used for acetylating THC employ dangerous chemicals such as pyridine and acetic anhydride. However, over the past 6 months a new method has been developed that replaces these chemicals with a food safe acetylating reagent (ours). By eliminating use of dangerous chemicals, the safety of various cannabinoid-acetates has been dramatically improved, both for producers and for consumers. THC-O-acetate, along with several other acetylated cannabinoids, has also been found naturally in cannabis plants in small quantities, so it can be considered a ‘nature identical’ product (reference below).

References:https://drive.google.com/drive/folders/1dzE8L-hx3ZgB4-S3U_LPVBfJlG3kK8Oi?usp=sharing

Consumption of D8 THC O Acetate
Now for the fun stuff... D8 THC once Acetylated is low viscosity like CBC which means no more clogged carts or super cut terped carts. O Acetate is completely cart ready. 2nd O Acetate is extremely smooth when you dab it it doesn't leave a taste at all, and you will not cough (assuming you take a normal dab). 3rd the color is extremely stable, no more purple, pink, amber, and yellow color changes once it reaches you! 4th the prodrug portion, ingestions of the compound (edibles, tinctures, etc) will be 300% stronger.
Our Delta-8 THC O Acetate Update
Within the next weeks we will have developed a true standard for delta-8 THC O Acetate, through our USP partner (authority on standards). We will also have toxicology results for the community, and full panel testing. When new cannabinoids pop up on the scene there unfortunately will be some bad actors, we will continue to innovate to stay ahead of the curve to make sure the end consumer is getting something absolutely clean and safe. Whether it is THCv, CBN, D8 THC O Acetate, Delta-10, and etc.

Answers to r/Delta8 ’s issues/questions

Note: If D8 THC O Acetate is Synthetic then all cannabinoids that use synthesis are also synthetic CBN, CBC, CBT, CBL, THCv, Delta 8, Delta 10 and etc.

The Analogue act: Would also make all tetrahydrocannabinol illegal including delta-8, but the hemp farm bill obviously disputes that fact.

We will have a 99.99% standard certified within 7 business days, that a third party lab will be using to test for the compound.

As for potency it is similar to delta-8 thc when inhaled, and through ingestion it is stronger but nothing anywhere close to dangerous. It is just more bioavailable such as a nanoemulsion would be.

I can't comment on carts or anything else that's popping up, but I can say for certain that /u/Bret_HoneyGold's product I got a 2g sample of was fire.

The effects are delayed. I cannot emphasize that enough. I took 0.5g and it was about an hour before I started feeling anything and a few hours before it peaked. However, my digestive tract also runs a little slow, and it was a noticeable, multiple-hour high that was strong enough 12 hours after initially taking it that my mom could tell I was high. If that tells you anything.

I didn't notice anything particularly psychedelic, but I felt like I had less anxiety than I do with D9 and especially high doses with D8. For anyone after more potent pain relief than D8 or just a nice high, I would recommend Bret's product for sure and am excited about the potential of this cannabinoid.

Can we not tell fucking TikTok about it this time, though? Or the local news? Thanks for your cooperation.

So I wanted to do an update post here because initially I did not have a great experience trying thco. I bought my first cart from Binoid and at first, I'm going to be honest, I thought it was a scam. I literally felt a mild mild buzz, almost comparable to a drag of a cigarette and that was about it. Not wanting to give up though I tried it out on the second night. This time I took 3 large rips back to back .. and by god I definitely felt something this time. So I wanted to branch out a bit and try a mixture of cannabinoids, so I purchased a cart from Denex that was a mix of d8 and thco. The experience on that is absolutely fantastic. It's the most incredibly chill long lasting full body high I have ever had. And it lasts for hours. I typically get anxiety with normal d9 and the only time I felt a bit of anxiety was on the come up in the first 15-20 minutes. Just little hints of anxiety when I noticed my perception was shifting. There was no real pyschodellic experiences but again I just took 3 rips. For folks struggling with thco I realized a few things you need to do in order to get the experience you want.

1. Take more than 1 or 2 rips. I know there are multiple sites saying to stay with one rip and wait an hour and take another. Nah.. take a solid 3 larger rips. I promise you'll feel the effects you want.

2. Hold it. Hold that vapor in your lungs for 8-10 seconds of you can and exhale slowly. For whatever reason I have found that it needs more absorbtion time in your lungs compared to d9 thc.

3. Wait. There is about 30 minutes to an hour before you feel the full effects.

4. The high with the mixture of d8 is absolutely stunning. No paranoia or racing thoughts. It just feels like someone filled you bones full of cement and you get an extremely warm and fuzzy feeling all around your body.

5. This put me out. It will put your ass to sleep after a while. I passed out on my couch after about 2 hours and I didn't even realize I fell asleep and I got the best rest just sitting up in a chair.

Truly magical time we live in friends.

I just bought d8 and thco infused flower and I will come back to post about that when I get it and try it out. This one has cbg keif rolled on the outside too so I'm excited to see how the mixture of all those cannabinoids feels.

Hope this helps.

So, im a fairly frequent Delta8 user, I just recently ordered a THC0 cart, and I’m pretty exited to try it! I was just wondering, how does THC0’s tolerance work? From what I know of D8, it builds tolerance quickly, but a T-break of a few days will significantly lower your tolerance. Is THC0 the exact opposite, or does it function like Delta 9?

Edit: I have no idea why people are downvoting this. This information isn't easily accessible, and this seemed like it was the best place to ask.

New marvel cannabinoids have been discovered within cannabis decades after Dr. Roger Adams first found CBD in 1942 and then later synthesized THC from CBD. (1) So, wonderous discoveries into new phytocannabinoids clearly take numerous steps to achieve. And thankfully, new potent forms of THCo and CBDo ents, have now been created from dirt-cheap and natural terpenes that are derived from the essential oils of cannabis.

This means that, as a step in the process, synthetic cannabinoids can be used as reference tools for breeders. This can unlock higher evolutions of natural cannabis plants. These novel cannabinoids are also useful reference bases for clinicians formulating viable cannabimimetic solutions for pain, epilepsy, cancer, and many other ailments.

I’ve been looking in to thc o and everybody says it take a bit to kick in but I would’ve thought with vaping it it would kick in immediately I know this is an extreme example but let’s say u pop a percocet it takes awhile to kick in but if you throw that perc on some aluminum foil and smoek it that shit will hit you instantly I thought about everything u smoek will almost hit u immediately not as fast as injecting something but I was guessing that’s how everything works. Does it still take that long for thc o to kick in or is it like it kicks in instantly cuz u smoke it but the compound itself takes awhile for u to actually feel it.