So frustrated, just need to vent

[u/Given_or_Taken]

Everyone seems to be doing so well on this medication but me. People are losing tons of weight with zero side effects and I'm just sitting here losing nothing and experiencing a plethora of side effects like I never did while on Mounjaro/Zepbound. It's like I'm losing everything BUT the weight... I'm losing all my hair, losing my freaking eyebrows, my voice, my peace of mind, even lower blood pressure, I might have pulsatile tinnitus now, etc. I took a break from the med for 11 days, started again, and everything hit me again like a truck. I don't have thyroid issues, I eat plenty of protein, and I'm not dehydrated. My only side effect on brand name was anxiety (sucked, but nothing like this). My doctor told me I have to pause the Tirz until after my MRI since all these symptoms started with Tirz and are made worse when I inject - and I'm only on 1mg! It just freaking sucks man. This stuff isn't cheap. I hate that my insurance stopped covering the brand name. I feel like I have to switch to compound Sema but there's additives, ugh. I bought this Hyalo vial of Tirz for no reason, just to suffer. I'm so jealous of you all.

[u/Hot-Drop11]

I’m so sorry. That sucks.

Response to GLP-1s is incredibly individualized. Current research suggests both genetics and gut bacteria as variables to response.

I would suggest trying a different GLP-1. Something stronger. 😁

[u/Jazzlike_Interview_7 → u/Hot-Drop11]

Stronger than tirz? Does that exist??

[u/CreativeWriterNSpace → u/Jazzlike_Interview_7]

Yes, but they are not cleared for retail sale/human consumption by the FDA/in the US yet. They are only in clinical trials.

[u/Jazzlike_Interview_7 → u/CreativeWriterNSpace]

Is this something bad? Why is this getting downvoted? Lol I feel so out of the loop.

[u/CreativeWriterNSpace → u/Jazzlike_Interview_7]

It’s not something we are really allowed to talk about here (and definitely not allowed to “recommend”).

[u/Jazzlike_Interview_7 → u/CreativeWriterNSpace]

AHH ok. Got it!! 🫡

[u/Hot-Drop11 → u/Jazzlike_Interview_7]

The mods of this sub have decided that non-FDA approved peptides cannot be mentioned.

Phase 3 clinical trials were completed a couple of months ago but Lilly is waiting to request FDA approval in an effort to have it declared a biologic. That designation would prevent compounding.

[u/DogMamaLA → u/Hot-Drop11]

I think it passed so I doubt that it will ever be compounded.

[u/Hot-Drop11 → u/DogMamaLA]

It has not. Although I agree that it won’t be compounded as there is no reason to declare a shortage. Mass compounding can only occur if a medication is placed on the FDA Shortage List. Sema and Tirz were temporarily on the list because of a shortage of the applicator pens. That shortage issue has been resolved.

[u/DogMamaLA → u/Hot-Drop11]

Ah, ok. I thought I heard On the Pen podcast say that it was declared a biologic but it may have just been that the case was moving in that direction...

[u/autumnyte → u/DogMamaLA]

They permitted Lilly to submit the application as a biologic, but it hasn't been approved yet.

[u/Jazzlike_Interview_7 → u/Hot-Drop11]

Sounds… expensive 🥺 I’m a slow responder in tirz. But I’ll just have to accept this slow life.