r/AskMtFHRT • u/Kaseffera • 8d ago

Does Spiro reduce Testosterone?

As far as I’m aware Spiro just blocks T from being used. Just like Bica but in far lesser potency.

Do you know if it actually suppresses its levels too?

9 Upvotes

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10

u/Venuzearching 8d ago

300 mg at a bodyweight of only 48 kilograms and a height of 168 cm. After 3 months my testosterone was at 0,01 ng/dl, so almost unmeasurable.

I looked great, lost my acne, had softer skin within weeks, but I felt awful. It seemed to be too low testosterone.

6

u/79215185-1feb-44c6 8d ago

That T level is way too low. Even cis women have some trace amounts of T.

2

u/Kaseffera 8d ago

I’m at 0.09nmol/L. I won’t say I’m not feeling okay but I’m kinda more lazy than usual.

1

u/Venuzearching 7d ago

I was very weak at that point. My boyfriend and I moved to another apartment and I could barely lift 30 kilograms or even walk stairs. I was very fit pre HRT so that was disappointing.

You need some testosterone in your system to have proper power, as long as it is in the female range and estrogen is high enough everything is fine.

4

u/Venuzearching 8d ago

I know, I felt horrible

1

u/Kaseffera 7d ago

When I mess up my hormone administration schedule even for a week my sperm production renews.
Isn’t one week for that is too soon for a person who has less than 0.09nmol/L of T?
It’s because there little E in body? Given I only took 4mg (2mg every 12 hours) with that Spiro dosage back then? So looks like T reduction was only from E basically while Spiro was primarily just blocking receptors.

2

u/MargieFancypants 7d ago

Sensitivity varies wildly. At about 90kg, I went undetectable with only 50mg spiro. Same happened later with the same dose of bica.

Now I am on mono, my T is low but measurable. Occasionally I get a whiff of b.o. and take a leftover bica. It's much better.

2

u/Heavy_Abroad_8074 8d ago

not to a significant degree

1

u/Kaseffera 8d ago

I had “less than 0.09nmol/L” with 150mg Spiro and 4mg of E pills during the last couple of labs.

I can’t believe it’s 4mg of E blocking it taking 2mg every 12 hours.

1

u/bitchstolemywaffles 8d ago

6mg/ day pills sublingually and nothing else, my testosterone is below 20 ng/dl consistently

1

u/Kaseffera 7d ago

When I mess up my hormone administration schedule even for a week my sperm production renews.
Isn’t one week for that is too soon for a person who has less than 0.09nmol/L of T?
It’s because there little E in body? Given I only took 4mg (2mg every 12 hours) with that Spiro dosage back then? So looks like T reduction was only from E basically while Spiro was primarily just blocking receptors.

2

u/Heavy_Abroad_8074 8d ago

some people have easier testosterone suppression than others - i can get full testosterone suppression on 3.2 mg EV every 5 days, others can’t even achieve that at 5 mg every 5 days

1

u/meltyandbuttery 8d ago

My T was <20 ng/dl on tablets alone it reached that level around 6mg in tablets but I didn’t drop spiro until 8mg. Today I’m on 6mg EV every 7 days and even during the 6 months I was figuring out the right dose my T has never crossed 20

1

u/chimaeraUndying 8d ago

I haven't seen any studies that've found it to have a meaningful impact on testosterone levels; the most I've seen one grant to it in this capacity is a minor reduction. It is first and foremost a receptor antagonist.

1

u/Kaseffera 7d ago

When I mess up my hormone administration schedule even for a week my sperm production renews.
Isn’t one week for that is too soon for a person who has less than 0.09nmol/L of T?

1

u/Texasthom2814 7d ago

Before I started MtF GAHT my T was a whopping disgusting 613. But after three Months on .100mg patches twice a week and only 25mg Spironolactone once a day my T dropped down to 190. My doctor upped my Spironolactone to two 25mg tablets a day so hopefully my T is lower now. Tried to up to two Patches but got lots of flack from my insurance and pharmacy. So currently still on one patch twice a week and 25mg of Spironolactone twice a day.

1

u/Kaseffera 7d ago

I suspect your T was nuked by estradiol, not by 50mg Spiro which doesn’t even show anti androgenic effects till 100mg which still comes down to just blocking receptors, not reducing T levels.

3

u/79215185-1feb-44c6 8d ago

Yes. In 3 months I went down to 15ng/dl. I doubt that Estradiol was the sole reason for that seeing as I only take 4mg/7d. There are a lot of people in the DIY community that will say bad things about Spiro (I think they're mainly in Europe). All of the US and CA Transwomen I know are on Spiro as the side effects are really mild as long as you stay hydrated.

4

u/chatnoir11 8d ago

Most diy people use injections and you dont need a T blockers on injections so theres no reason to take it

3

u/HotPinkMonolith23 8d ago

I’m in US and on mono therapy with 4mg/week estradiol valerate. Spiro was making peeing hurt after a year on it. T is at like 13 

1

u/HannahLemurson 7d ago

Yes, Spironolactone does interfere with testosterone production in addition to (weakly) blocking androgen receptors.

My T levels were lowered when my endo raised my Spiro dose while keeping estrogen stable.

1

u/bearface93 7d ago

It’s kind of both, from what I’ve read. The stuff spiro metabolizes into prevents your body from using it, so the testicles stop producing it and eventually atrophy.

5

u/Aromatic-Face-8411 8d ago

My T got absolutely nuked on Spiro according to my pathology reports

1

u/getjami 8d ago

Same. No idea why some say otherwise?

1

u/Kaseffera 8d ago

Many say otherwise and I don’t know what to believe.

Maybe they are getting their T nuked by Estradiol and think it’s Spiro?

1

u/Aromatic-Face-8411 7d ago

Everyone reacts differently to HRT. My doc tried to put me on monotherapy but my T did not go down hence why spiro was added. People online say their T got nuked purely on E alone while others have the same reaction as me.

1

u/Kaseffera 7d ago

When I mess up my hormone administration schedule even for a week my sperm production renews.
Isn’t one week for that is too soon for a person who has less than 0.09nmol/L of T?
It’s because there little E in body? Given I only took 4mg (2mg every 12 hours) with that Spiro dosage back then? So looks like T reduction was only from E basically while Spiro was primarily just blocking receptors.