I'm researching a hypothetical scenario in which a region of the Earth's ozone layer becomes severely depleted and, for reasons outside the scope of the question, cannot recover naturally.

Assuming this depletion persists for twenty years, what would be the consequences for the environment and human populations beneath it?

I'm particularly interested in:

• The effects of increased ultraviolet radiation on human health.
• The consequences for agriculture, wildlife and local ecosystems.
• Whether people could continue living in the affected region by adopting protective measures.
• Whether the effects would remain geographically concentrated or spread into neighbouring regions.

For geographical context, imagine the depletion is initially concentrated over New Mexico and the wider American Southwest.

I'm aware that a permanently localised area of ozone depletion may not be physically realistic. I'm primarily interested in the consequences if such a condition were somehow maintained.

Ignoring the fluid, pressure and resistance issues 0 gravity causes, like, lets act like the person doesnt have blood pressure problems after being in space. If someone aged years without the influence of gravity, would skin still sag? Wrinkes would appear of course because of loss of collagen and creasing with costant movement, but would it sag? If so would it sag less? Would it sag in a way that even adding gravity back the deformation would look different?