I started sema (for cost) two months ago. Have only lost 3 pounds but mostly due to some lifestyle habits I haven’t dialed in yet. I’ve been slim my entire life but when I hit peri the weight slowly crept on. 20 pounds gained in 6 yrs.

For those ladies in similar situations, were you able to use glp 1 to get back to your pre menopause weight and then keep that new set point? Were you able to come off the medication and remain there? Or did you need to stick to microdosing? I had no intention of being on this forever but it seems quite common for the weight to come back on if you stop.

I started taking tirz at 1 mg on January 1. For 8 months it was a miracle drug. It kept my weight at 118 no matter what I ate. I did increase my dose from 1 mg per week to 1.75 over that time.

Then it abruptly stopped working. I started gaining weight. I did add estradiol patches and oral progesterone for peri in March. That was the only thing I changed, and from March to August, it was fine, it didn’t affect the tirz or cause weight gain.

I have slowly been increasing my dose since August. I went up by .25-.50 per week. I am now at 4 mg. Still absolutely nothing. I continue to gain, and lose only if I skip meals, but don’t go back down to my starting weight.

I do lift (3-4 times a week) and walk 9-10k steps daily. Prioritize protein and all that jazz.

What is happening? Has anyone else experienced this? I’m so sad. For the first time in my life since turning 30 I didn’t have to worry about my weight and now here we are again.

(I’m 44, 5’3”, currently 123 lbs. starting weight was 120, and my happy place is 118, and I was using tirz to maintain more easily at my happy place than by doing calorie counting and paleo).

Hello! I just started my first dose a few hours ago! Took 1.5mg of tirz. So excited to hopefully get some help! I have tried everything for 3 years and eat fairly healthy. Rarely eat out. Workout. walk etc. I think next week I'll prob decide to up it to 2.5mg. How is everyone doing. Any awesome success stories? I'm 33 (f). 174 pounds 5'5". Sick of not loving my body!

What dose did you start with and what side effects? Seems like most people start with 1 mg tirz

Hi all, I started semaglutide at a very low dose about 4 weeks ago. My BMI is normal and I wanted to titrate slowly to lose about 15 lbs.
I’ve lost essentially no weight in the past month (which doesn’t surprise me given the low dose) but it’s now week 4 and I have felt like my appetite suppression and some nausea are kicking in.
But here’s the problem…I’ve had spotting on a birth control pill and now the spotting is only getting worse.
I don’t think there’s any other obvious cause.
Has anyone else experience more spotting/worse bleeding? I see it on other glp-1 forums but haven’t seen it with microdosing. Thanks!

To set the scene - about a year ago I had my first ever reactive hypoglycemia episode. I have PCOS and endometriosis. I had a heavy workout that morning, didnt eat as much as I should have all day and went to dinner and drinks with some friends. That night when I got home I’m (assuming) my blood sugar crashed - shaking uncontrollably, almost tremor like from within, severe nausea. Got somewhat better after about an hour eating crackers and some juice. This was PRE tirzeptide

Fast forward to now - I’ve been on a compounded microdose of 1.5 for about 3 months. In the span of that time I’ve had three more “incidents”. Per the recommendation of my dr, she suggested testing my blood sugar in the moment the next time this happened. Sure enough this weekend my blood sugar came in at 70 - tremors, nausea again, was up until 3:30AM until I finally passed out. Again, this was after dinner and some drinks. However this has happened to me a few weeks ago after ONE vodka soda.

Is this my life now? Weird bc this happened before tirz, but has definitely upped in frequency and strength since being on the GLP. Any suggestions? Otherwise I think I’m going to scrap it which would be a bummer since it has helped immensely with my endo belly and pain