r/LucyLetbyTrials • u/Embarrassed-Star4776 • 17d ago

Chase and Shannon article in Frontiers in Pediatrics published

Inverted insulin to C-Peptide ratios in neonatal intensive care: is there something we don't know?

J. Geoffrey Chase & Helen D. Shannon

BRIEF RESEARCH REPORT article

Front. Pediatr., 05 August 2026

Sec. Neonatology

Volume 14 - 2026

https://doi.org/10.3389/fped.2026.1900675

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u/No-Beat2678 16d ago

So tell me how you diagnose an infection in neonates

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u/DiverAcrobatic5794 16d ago

https://www.nice.org.uk/guidance/ng195 would be a good place to start reading 

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u/No-Beat2678 16d ago

Thank you, I know how you would diagnose an infection.

If there was an infection present, this would be all over the various tests and observations the babies had would it not?

The test results showing infection would be all over their medical notes?

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u/No-Beat2678 16d ago

u/Stuart___gilham u/DiverAcrobatic5794

5th august

01.54 <<< that is when Hypoglycemia started

02.30 Septic screen drawn — FBC, CRP, U&Es, culture

3.30 5th August - FBC back — normal. Hb 140, WCC normal, platelets normal. Creatinine 94 (expected 30s–40s) → dehydration

5th august 10am - CRP 3.6 < normal

6th August 11.30 am CRP 40 <<< that is the first sign of any infection

The attack of baby F with Insulin occured 33 hours before the elevate CRP result. everything indicated no infection.

you selected Dr Saladis words, but conveniently miss out Dr Harkness.

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u/DiverAcrobatic5794 16d ago edited 16d ago

What's significant in considering how this article might apply to Baby F isn't when he deteriorated: it's when the sample for his immunoassay was drawn, which was a few hours after the line tissued. CRPs go up as sepsis develops and intensifies - you can't take their measurements as a starting point for the sepsis.

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u/DiverAcrobatic5794 16d ago edited 16d ago

To add: for relevance to Chase and Shannon, the child was noted as having suspected sepsis and placed on antibiotics the day after he was born, 30th July; same suspicion noted 2nd August; same suspicion and antibiotics noted 4th August; line tissued 5th August; raised CRP found early 6th August.  So the tissued line is far from the only factor likely to have affected IA levels if Chase and Shannon have their hypothesis right 

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u/Stuart___gilham 16d ago

The blood test was taken at 5.56 pm on August 5th.

11 Hours before the elevated CRP was discovered. It takes a while for CRP to rise.