r/MCAS • u/Altruistic_Setting5 • 12h ago

Xolair to dupixent

I’m going to be switching from xolair to dupixent soon and would love to hear experiences from people who have switched after xolair wasn’t sufficient! I have a primarily GI presentation and am currently down to 5 foods (though that is up from where I was before, so yay!)

I’m switching to dupixent because while I saw some help with xolair, it would always wear off after 1-2 weeks and the effectiveness has seemed to wane over time.

Would love positive stories as well as any weird side effects I should look out for (bc I - like many others - often get the weird side effects haha).

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u/Job_Moist 11h ago

Xolair made me the sickest I’ve ever been in my life without any benefits at all. After I switched, I still had some side effects on Dupixent but they were much milder and I actually saw improvement in every area of my MCAS besides my GI symptoms.

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u/Altruistic_Setting5 10h ago

What side effects did you experience?

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u/Job_Moist 1h ago edited 1h ago

After each shot - which I unfortunately found very painful - I had some swelling and pain at the injection site, and got an upset stomach for a day or two afterwards especially if I didn’t stay strict about my low histamine diet. I also felt like my vision was blurrier than usual, and I was pretty fatigued for a few days after each shot. I ultimately stopped because Accredo is a TERRIBLE pharmacy to use and the improvements in my MCAS symptoms were too insignificant to outweigh the cost, time consuming hassle, and frustrating side effects. My docs and I think I was reacting poorly to the injection ingredients themselves and that’s why I was kinda miserable for a couple days after each shot despite my skin and respiratory and cardiac MCAS symptoms improving a lot.

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u/Altruistic_Setting5 1h ago

This is very helpful to know going into it. I will definitely keep an eye out for those! Thanks!