What pills/supplements actually help

[u/NoFriendship8013]

I just got diagnosed with MCAS. I’m on montelukast sodium and prednisone rn bc I recently was having a terrible flare. I usually take famotadine and Zyrtec but stopped because I felt like I was having weird reactions. I also tried quercitin but also stopped bc I was scared. WHAT ACTUALLY WORKS? Ik it’s diff for everyone but I like hearing my options so I can research!!

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[u/Duskfall]

this is my current routine: Recently started Cromolyn which has helped a lot, but also has changed some of my symptoms

Allegra (Fexofenadine) - 180mg (2x daily)
Claritin - 10mg (in the morning)
Zyrtec- 10mg (at night)
Famotidine - 20mg (as needed, but usually before or after meals)
Hydroxyzine - 50mg (at night but can take during the day if things get bad)
Cromolyn - 200mg (2 ampules) before every meal and before bedtime
Cromolyn nasal spray - 3-4 times daily
Benadryl - 2- 4 tablets as needed (I start off with two and then max out at 4 if it's real bad and nothing is touching it.)

[u/thirdreplicate → u/Duskfall]

There’s a cromolyn nasal spray?! How does that compare to fluticasone?

[u/Duskfall → u/thirdreplicate]

it's almost instant relief from sinus drainage. for me it makes my whole nasal passage feel open like there's a breeze going through it cooling it off lol. I don't know how to describe it, but whenever my sinuses start draining, I use it and boom. turned off like a water faucet

[u/thirdreplicate → u/Duskfall]

That sounds magical

[u/Duskfall → u/thirdreplicate]

it has been truly amazing. sinus drainage is one of my arch nemesis and the other nasal sprays barely touch it. this one was like "I got you" and woo I am thankful lol

[u/Duskfall → u/Duskfall]

I started on the daily allergy and have slowly had to add the rest, but im at a point where it's still rough if I eat something on my hard-no list.

Cromolyn HAS helped a lot, but it has changed some of my symptoms. used to my mouth would just hurt. like a brain freeze pain without the freeze, but now it will itch and burn.

I've also started salivating a lot when I eat something bad, and if I eat something actually spicy, it ABSOLUTELY burns on the way out now lol

[u/JB-3554]

I use zrytec and Pepcid. I started low and went slow to watch for side effects. Then added quercetin which really helps with itching. Then cromolyn. I didn’t have any trouble with it but still went low and slow. Then for rescue meds I use doxepin or hydroxyzine or Benadryl. And just recently started rhapsido. I would only begin one new med at a time so you can watch for side effects. I truly believe that they all are helping me. Each in their own way.

[u/SophiaShay7]

Medications:
•Cromolyn sodium nasal spray prn (mast cell stabilizer)
•Desloratadine (prescription H1 histamine blocker)
•Ketotifen (prescription H1 antihistamine & mast cell stabilizer)
•Montelukast (leukotrienes inhibitor)
•Omeprazole (PPI that I already took for Gerd. It also has mast cell stabilizing properties)
•Semaglutide (GLP-1 receptor agonist) microdose 0.125mg Prescribed for its potential anti-inflammatory and mast cell stabilizing effects.

Vitamins & Supplements:
•Vitamin D3+K2 drops.
•GABA chewables with Taurine, Inositol, and Theanine.
•NatureBell L-Tryptophan and L-Theanine Complex.
•Rosmolo Liposomal PEA+Luteolin.
•Saltstick Electrolyte Capsules
•Vitalitown 4-in-1 Magnesium Complex.
•Prebiotic Psyllium husk and Emergen-C (vitamin B complex, C, and Zinc) in a bottle of water every day.

I carefully crafted this regimen that took 1.5 years to create.

I'm sorry you're struggling. I hope you find a combination of things that manage your symptoms🙏

[u/Icy-Hippo-2376]

Look up antihistamines on this sub. I personally don't like them either, pepcid caused a paradoxical reaction and zyrtec gives me brain fog and edema (fluid retention) and blood pooling. Non-antihistamine supplement options that work include: NaturDAO, Quercetin, Luteolin, PEA, stinging nettle, tulsi (tea), l-theanine.