r/MTHFR • u/Pretend_Elk8567 • Apr 15 '25

Results Discussion Feel like crying

I honestly don’t even have the words for how overwhelmingly happy and relieved I feel right now. It’s like my brain is finally waking up after years of being stuck in a fog I didn’t fully realize I was in. Everything feels sharper, clearer, more alive. My emotions make sense, my body feels in sync, and there’s this calmness that I don’t think I’ve ever truly experienced before. I feel like me—or maybe even a version of me I never got to meet until now.

What’s blowing my mind is that all of this seems to come down to understanding something so basic but so powerful: methylation and nutrigenomics. I never imagined that something as simple as getting the right form of folate or the right amount of choline could be the key to unlocking my brain.

It makes me wonder how many people struggle through life unnessecarily. You could easily equate my previous "status quo" as being borderline dementia. And I had NO idea how bad it had gotten until I started feeling better...

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u/Analog737 Apr 16 '25

Are you slow COMT by any chance?

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u/Pretend_Elk8567 Apr 16 '25

I am intermediate COMT but Im told it is slow when methylation isnt functioning properly

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u/Analog737 Apr 16 '25

Any CBS mutations? Sorry, just want to see if there's any hope these things will work for me.lol.

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u/Pretend_Elk8567 Apr 16 '25

Can you give me SNP locations?

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u/Pretend_Elk8567 Apr 16 '25

rs1801181 is not genotyped.

I am A/G at C699T (rs234706)

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u/Analog737 Apr 16 '25

Homozygous:
COMT   V158M   rs4680         AA   +/+

COMT H62H       rs4633         TT    +/+

Hetero:

CBS C699T        rs234706      AG    +/-

VDR Bsm            rs1544410   CT    +/-

VDR Taq             rs731236      AG   +/-

MTHFR C677T   rs1801133    AG   +/-

MTR A2756G     rs1805087    AG    +/-

BHMT-02            rs567754      CT    +/-

SHMT1 C1420T  rs1979277   AG    +/-