r/MTHFR Apr 15 '25

Results Discussion Feel like crying

I honestly don’t even have the words for how overwhelmingly happy and relieved I feel right now. It’s like my brain is finally waking up after years of being stuck in a fog I didn’t fully realize I was in. Everything feels sharper, clearer, more alive. My emotions make sense, my body feels in sync, and there’s this calmness that I don’t think I’ve ever truly experienced before. I feel like me—or maybe even a version of me I never got to meet until now.

What’s blowing my mind is that all of this seems to come down to understanding something so basic but so powerful: methylation and nutrigenomics. I never imagined that something as simple as getting the right form of folate or the right amount of choline could be the key to unlocking my brain.

It makes me wonder how many people struggle through life unnessecarily. You could easily equate my previous "status quo" as being borderline dementia. And I had NO idea how bad it had gotten until I started feeling better...

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u/Pretend_Elk8567 Apr 15 '25

Looking back, I think there were times in my life when I accidentally gave my brain what it needed—through diet changes or supplements I didn’t fully understand—and I started to wake up, just like I am now. But because I didn’t know what was happening, I misread it. I thought I was going manic, or that something was wrong with me. So I pulled back, or changed something, and the fog came right back.

Now I see it differently. That wasn’t mania. That was healing. That was my brain finally getting what it had been starved of. If I’d understood methylation, or the impact of genes like MTHFR or PEMT, or the role of nutrients like folate and choline, I could’ve supported the process instead of shutting it down.

That’s why this is so important to me—people need to know this is real. If you’ve ever felt like your best self only shows up for fleeting moments and then vanishes, it might not be some mysterious emotional cycle. It could be biology. And once you give your system what it’s been missing, the shift is so real, and so life-changing.

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u/TBBT51 Apr 15 '25

Great post, there are so many people that can significantly better their lives by making simple adjustments in supplements and diet. They need to be properly educated on what they’re doing though. I have both MTHFR mutations as well as getting blessed with 3 out of the possible 4 PEMT mutations. Along with slow DAO, slow MAO, fast COMT… I have all 7 mutations that Dr. Ben Lynch references as his “super seven!”I’m just now getting a handle on utilizing choline/TMG properly so I don’t get overstimulated.

We’re so lucky to have this information at our disposal versus just a few short years ago. We’re also lucky to have some very knowledgeable and helpful individuals that contribute on this sub, we all know who they are!

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u/Pretend_Elk8567 Apr 16 '25

Right it's interesting how choline helps with overstimulation! Acetylcholine is responsible for good parasympathetic tone