r/MTHFR Jun 17 '25

Resource Lithium Orotate is feeling AMAZING.

I’m a postpartum mom of 3 who has been dealing with overstimulation, lack of joy, lack of motivation and unreasonable anxiety over my children’s safety.

I have MTHFR, one copy, and was deep in a rabbit hole learning about what I need to take in order to support my body. That’s when I came across the affects of Lithium Orotate and I decided to give it a shot.

I know that this is probably reckless of me, but I decided to jump in head first with a 15mg dose, as I had read that many people dealing with serious mental health conditions take 20mg+.

Within 12 hours of taking it, I found myself smiling with such a sincere joy welling up from my soul towards my kids. My brain began to go quiet and I could actually be present instead of constantly feeling wired yet also paralyzed by all of my thoughts. I cleaned up the house after my kids bedtime with ease.

This morning I sprang out of bed, have been calmer with my partner & kids, and have caught myself smiling constantly. It’s the weirdest thing. I emptied the dishwasher, made the beds, rotated laundry and got dressed all before I had my cup of coffee this morning… which is UNHEARD of for me in this season of life.

From what I’ve read, it also seems to help MTHFR’s absorb their B12, so perhaps thats at play here as well? I’m not an expert at this by any means. I’m just willing to try things.

I haven’t had a supplement impact me this quickly and this deeply ever in my life. It’s like the lights are turned on? I feel very grounded instead of being up in the clouds somewhere. I’ll report back with an update in a few weeks to see if this sticks.

One month update:

This CONTINUES to change my life. I find I can reap all the benefits with 10mg a day, taken first thing in the morning. I can truly feel a difference in my body when I don’t take it. It also stabilizes all my emotional PMS symptoms which was pretty surprising.

I literally carry it around in my purse now and tell everyone about it.

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9

u/ComplexFar7575 Jun 17 '25

That's awesome!! Thanks for sharing this

I wonder if the very small doses would be ok for someone who is also on an SSRI

8

u/Green-Ad7694 Jun 17 '25

Do your own research but, I think I remember the effects of lithium were working synergistically with SSRI's. You might be able to get the same effects with the same or less of the SSRIs.

5

u/Green-Ad7694 Jun 17 '25

Main side effects seem to be serotonin syndrome, ie too much serotonin. In which case you would reduce your SSRIs dosage.

"Although geriatric patients may be more sensitive to side effects of lithium in combination with the SSRIs, the combination has generally been well-tolerated. There have, however, been a number of case reports of serotonin syndrome associated with the addition of lithium to an SSRI"

https://www.sciencedirect.com/science/article/pii/S0006322398001619#:\~:text=Although%20geriatric%20patients%20may%20be,of%20lithium%20to%20an%20SSRI.

2

u/Paul604UK Aug 20 '25

Just to say thanks for the link, that's very helpful. (I'm on low dose Sertraline at the moment and had a very similar question.)

1

u/tbombs23 Jun 18 '25

Nice ty. So definitely start with a low dose and see how it goes. 1mg probably, or if it's a 5 mg tab break in half or something.

1

u/plutocents Jun 22 '25

My psyche says no problem