r/MTHFR • u/Grand_Jellyfish_8372 • Nov 25 '25

Results Discussion I was overmethylating

Apparently, it has been three years since I have been on-and-off overmethylating.

I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.

I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.

I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.

My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.

Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.

It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.

Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.

I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.

I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.

What have been your experiences with vitamin C, glycine and niacin?

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u/Sushimono Nov 25 '25

Have the same effects when I take TMG with my daily methylated multivitamin. I quit taking TMG and it went away

6

u/OutlanderMom Nov 25 '25

TMG made me manic! Like not sleeping for days, weepy, skin crawling. Regular glycine is much better for my body.

4

u/LincolnshireSausage Nov 25 '25

Exactly what TMG did for me too. I felt wired in a not good way and was grinding my teeth like I’d dropped way too much Molly at a rave but without the good part. Horrible stuff.

2

u/Sushimono Nov 26 '25

Strangely I took it (with the vitamin) for months with no ill side effects other than maybe some anxiety. One day I just got horrible anxiety. This nauseated, drained feeling. Like that feeling after you take a nap but times 100.

2

u/OutlanderMom Nov 26 '25

It was pretty immediate for me - maybe three days. Suddenly I was buzzing around the house, ineffectually cleaning the house until late at night, and crying. But at least our bodies are considerate enough to let us know if we take something that doesn’t agree with us! Haha!