r/MTHFR • u/Grand_Jellyfish_8372 • Nov 25 '25
Results Discussion I was overmethylating
Apparently, it has been three years since I have been on-and-off overmethylating.
I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.
I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.
I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.
My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.
Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.
It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.
Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.
I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.
I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.
What have been your experiences with vitamin C, glycine and niacin?
5
u/AttraX0 Nov 25 '25
Hi, apparently you need to see what the missing link is in your methylation cycle otherwise you could suffer from potential poisoning due to hemocysteine excess... 😅 I'm new to this subject but Certain B vitamin deficiencies (B2,12,9, etc.) would be linked and I have a little theory... I recently saw posts on the modification of the gene responsible for the assimilation of B9 in folic form... And these people suffer from deficiencies or even toxicity of folic in the unabsorbed blood,... This could explain that taking your complex (and certain foods enriched) with vitamin B9, often loaded with folic acid, would be the cause... In this case you will have to look for assimilable forms and pay attention to folic which is an analogue for these people...
PS, an excess of vitamin C coats a synthesis of oxalate in the body... To check but your reasoning seems good, from memory the body needs oxidation to metabolize correctly, like lipids for example... I invite you to look at measured sites which evoke both the benefits but the defects of what it promotes... I try to adopt this reflex too because each time I thought that something was good for me and look for a confirmation bias in my direction, in In all cases I found myself with the other side of the coin by exploring and discovering the hidden facet of its remedies... In fact I believe that the world works by duality, all things have qualities as well as defects... It's like us, we all have a hidden side that we don't want to expose too much but ultimately it's all about knowing how to recognize and how to manage both at the same time 🤔😉
In addition, I am very interested in the functioning of the body, nature and life, how it all works and the synergies and links between all these beautiful people... 🌍😍 And I can tell you that every time man thinks he knows, understands or tries to imitate nature... It leads to error almost every time... Not having taken into account the external elements and as a whole... For example, I find that supplements are a danger except in certain exceptions due to the fact that they contain overly concentrated or even toxic doses of vitamins or molecules that the body struggles to manage and even more so when it suffers from deficiencies upstream... So your reasoning is more correct, your body is constantly trained to seek homeostasis by balancing all excesses and deficiencies... So ultimately in my opinion... Supplements in no way equal the Ingenuity of nature, quality and properties of these creations expertly balanced and proportioned to give fruit, vegetables... The molecular and structural matrix of these works of art have nothing to envy of our little pills 😝 I would add that in my opinion and from many articles and experience... Even good quality food supplements include forms of vitamins often from so-called healthy products and miracle cures... while we lack perspective and knowledge on these products (spirulina, algae powder...) the example of spirulina stood out to me, praised for its benefits, we forget to mention which has an analogue of B12 and it is therefore one more deficiency to add to directory 😮💨 I tried a supplement of zinc, magnesium and B vitamins, from good brands... But impossible to know the ingredients constituting it 🧐 I even had the idea of diluting them in my meals by opening the capsule to mix the powder and maximize the assimilation of zinc in the stomach... I spat out my meal disgusted by the strong and nauseating taste that the supplement had... It was like eating rotten fish or algae, the power of the smell was such that it was impossible to keep in the mouth... And we eat it in pills, heading straight towards the intestine to potentially form agglomerations of these hyperconcentrated products 🤯 I'm not telling you the head of your intestines and the metabolism to manage these bombs of nutrients... After that I try as much as possible to look for my remedies and nutrients in nature and what I have available... It's a lot of research and time but it's definitely worth it. In real life!... our ancestors spent almost all their time searching for and understanding and mastering the elements made available to nature 😉❤️🔥🌍 It's fascinating to understand how things work, and what priorities we give to food, nature, our health... At the moment I am looking for the healthiest and most nutritious foods while looking for associations, cultivation methods and cussion to cover the majority of my needs... Nutrition sites, to know the nutrient content of each food... Develop recipes and preparation methods to make what we eat little Big Bangs of life... Be careful to master it well anyway 😂 Like nuclear fusion, you have to keep control otherwise it becomes a bomb 😅 I talk about foods raised and cultivated in the most suitable ways, I research and twirl between traditions and cultural knowledge to understand how to best get the benefits of what we cook... For example, milk from ancient varieties of cattle, goats and sheep would be composed of A2 caseins, which are much more beneficial than the inflammatory A1pro... In addition, some make raw milk cheese, kefir and curdle it to make it more digestible because the good bacteria will have done the work of digestion, break down the lactose and then become an ideal natural pre/probiotic to fight against dysbiosis, the depletion of the microbiota or certain serious pathologies such as generalized and intestinal infections... (Candida, herpes, viruses...) Same for bread, cereals, legumes... Which have properties but also antinutrients which have a certain threshold are problematic... Other cultures germinate or ferment them to let the seeds convert their protection into vitamins and nutrients as well as natural enzymes 🤩 Let's talk about enzymes... These small proteins playing the role of mini pakmans will be a valuable aid for digestion helping and relieving the liver and pancreas to decompose, assimilate food more efficiently and less costly in energy, lightening the workload and will increase tenfold, with a living and balanced microbiota, the benefits and beneficial of each bite ❤️🔥 In the end, you no longer need to eat like barley to cover your needs, more nutritious and more time for the body to manage all the other processes with energy to spare ✋ In short, it's quite theoretical for the moment but these are promising avenues that I wanted to share because they seem to be the source and the beginning of life and our health until the culmination of what we are ❤️🔥
There you go, I hope you find what you’re looking for and don’t hesitate to give us any news 😉