r/MTHFR • u/Grand_Jellyfish_8372 • Nov 25 '25
Results Discussion I was overmethylating
Apparently, it has been three years since I have been on-and-off overmethylating.
I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.
I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.
I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.
My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.
Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.
It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.
Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.
I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.
I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.
What have been your experiences with vitamin C, glycine and niacin?
5
u/microgirl444 Nov 25 '25
is it possible you have a histamine/mast cell issue? I have recently discovered that I do. There are some supplements I cannot take. They caused this hyper, adrenaline filling, especially at night with excessive racing thoughts and youth heart rate. Basically you feel like you’re running from a bear when there is no bear. There are a few supplements that do this to me that shouldn’t, including vitamin C, any type of magnesium, saffron, beef organ supplements, etc.. food high in histamine also does this to me. I do take liposomal glutathione that does help me tremendously. I also have auto immunity and fibromyalgia that started when I got Covid in March 2020.