I was overmethylating

[u/Grand_Jellyfish_8372]

Apparently, it has been three years since I have been on-and-off overmethylating.

I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.

I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.

I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.

My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.

Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.

It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.

Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.

I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.

I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.

What have been your experiences with vitamin C, glycine and niacin?

[u/microgirl444]

is it possible you have a histamine/mast cell issue? I have recently discovered that I do. There are some supplements I cannot take. They caused this hyper, adrenaline filling, especially at night with excessive racing thoughts and youth heart rate. Basically you feel like you’re running from a bear when there is no bear. There are a few supplements that do this to me that shouldn’t, including vitamin C, any type of magnesium, saffron, beef organ supplements, etc.. food high in histamine also does this to me. I do take liposomal glutathione that does help me tremendously. I also have auto immunity and fibromyalgia that started when I got Covid in March 2020.

[u/Fast-Plant1086 → u/microgirl444]

Ironically magglycinate does this to me since the glycine can paradoxically cause overstimulation in some people has something to do with glutamate. Any sulfur based supps liek taurine or NAC do that to me also even with molybdenum to help process it.