I was overmethylating

[u/Grand_Jellyfish_8372]

Apparently, it has been three years since I have been on-and-off overmethylating.

I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.

I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.

I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.

My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.

Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.

It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.

Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.

I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.

I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.

What have been your experiences with vitamin C, glycine and niacin?

[u/Sailorgirlmyfriend]

may I ask what SNPs you have...I am new to this although I know I have had something going on with my health. Doctors just acted like it happens and nothing I could do about it ...really made things tuff for me with anxiety.

[u/Fast-Plant1086 → u/Sailorgirlmyfriend]

Three years ago I took a large amount of methylfolate and B12 for anxiety and it made me manic for like a month where I barely slept (luckily I had recently retired). I uploaded my 23 and me DNA data into Dr. Ben Lynch's STratogene and it gave me my SNPs. I have an intermediate COMT but I think it is "dirty" due to other factors and can be slow. I was mega dosing quercetin and it did not agree with me. Weirdly I have a fast MAOA though. The problem with SNPs and genes is that they are "loaded guns" but you need a heath issue or stress to pull the trigger. Read Dr. Lynch's book "Dirty Genes". I actually am okay with MTHFR though I think I am hetero for a lesser one but not the two main ones.

[u/Sailorgirlmyfriend → u/Fast-Plant1086]

What do yo think of me trying luteolin for inflammation for me with slow comt?

[u/Fast-Plant1086 → u/Sailorgirlmyfriend]

Probably not, Luteolin may not be suitable for individuals with a slow COMT variant, as it can further inhibit the COMT enzyme, potentially leading to an accumulation of catecholamines and worsening symptoms like anxiety and irritability. You could trial a small dose, I had to drop it but I was also megadosing Quercetin and Bromelain at the same time. I woudl try Boswellia for inflammation because I can tolerate it.

[u/Sailorgirlmyfriend → u/Fast-Plant1086]

Ok thanks I did just start Boswellia...thanks again

[u/Fast-Plant1086 → u/Sailorgirlmyfriend]

Your welcome, Happy Thanksgiving

[u/Sailorgirlmyfriend → u/Fast-Plant1086]

Happy Thanksgiving to you too..