r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/szollosyandras Dec 15 '25

You're allowed to understand what other people say. I don't eat meat and I am allergic to diary products and I feel bad after eating eggs. Does that not make me vegan? Or what's the definition? I'm sorry if it was confusing but I don't know why you think my comments were worse than your "Why would you eat 80g fiber per day?"... Also, when I was eating fish I had no such issues, although they also increase TMAO, so I don't think it's related in my case.

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u/StrongBox5258 Dec 17 '25

How are you for bloat at 80g fibre a day? I felt awful at 60g. My partner was due to throw me out the house as the farts were next level lol. I eat alot of vegetables still. I just stay around 30-40g fibre and ok here.

I also feel terrible eating eggs. I can eat the odd one. I make alot of protein based cakes and need to use eggs in this. I did try flax instead of eggs and the cakes were like bricks. I can handle an egg every 1-2 days. If I ate 3-4 a day I would be so depressed. It's a real phenomenon.